pH-sensitive interpenetrating polymer network microspheres of poly(vinyl alcohol) and carboxymethyl cellulose for controlled release of the nonsteroidal anti-inflammatory drug ketorolac tromethamine

2015 ◽  
pp. 1-8
Author(s):  
Ebru Kondolot Solak ◽  
Akın Er
Keyword(s):  
Controlled Release ◽  
Vinyl Alcohol ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Ph Sensitive ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol ◽  
Ketorolac Tromethamine ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Jingqiong Lu ◽  
Yinhui Li ◽  
Deng Hu ◽  
Xiaoling Chen ◽  
Yongmei Liu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Aspartic Acid ◽  
Vinyl Alcohol ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Simulated Gastric Fluid ◽  
Poly Vinyl Alcohol ◽  
Simulated Intestinal Fluid ◽  
Swelling Properties ◽  
Drug Controlled Release

Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

Semi-interpenetrating polymer network microspheres of gelatin and sodium carboxymethyl cellulose for controlled release of ketorolac tromethamine

2006 ◽  
Vol 65 (3) ◽  
pp. 243-252 ◽  
Author(s):  
Ajit P. Rokhade ◽  
Sunil A. Agnihotri ◽  
Sangamesh A. Patil ◽  
Nadagouda N. Mallikarjuna ◽  
Padmakar V. Kulkarni ◽  
...  
Keyword(s):  
Controlled Release ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Sodium Carboxymethyl Cellulose ◽  
Ketorolac Tromethamine

Electric stimuli responses to poly(vinyl alcohol)/chitosan interpenetrating polymer network hydrogel in NaCl solutions

2002 ◽  
Vol 86 (9) ◽  
pp. 2285-2289 ◽  
Author(s):  
Seon Jeong Kim ◽  
Sang Jun Park ◽  
In Young Kim ◽  
Mi-Seon Shin ◽  
Sun I. Kim
Keyword(s):  
Vinyl Alcohol ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol

Water behavior of poly(vinyl alcohol)/poly(vinylpyrrolidone) interpenetrating polymer network hydrogels

2003 ◽  
Vol 89 (1) ◽  
pp. 24-27 ◽  
Author(s):  
Seon Jeong Kim ◽  
Sang Jun Park ◽  
Kay Hyeok An ◽  
Nam Gyun Kim ◽  
Sun I. Kim
Keyword(s):  
Vinyl Alcohol ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol ◽  
Water Behavior
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