scholarly journals MAP kinase dysregulation by Coronaviruses

2020 ◽  
Author(s):  
Pardis Tabaee Damavandi
Keyword(s):  
Gas Exchange ◽  
Map Kinase ◽  
Low Dose ◽  
The Body ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Wide Range ◽  
Alveolar Level ◽  
Difficult Cases ◽  
Modest Activity

An opinion on what may cause complications displayed by the current coronavirus whereby it seems MAP kinase is 'overworking' in the process of virulence. Although the virus is completely inactivated in the presence of known chemicals such as acetone and zinc it is by accessing the lungs that it manages to cause respiratory distress. The virus is quite an amphiphilic molecule which makes its absorption easy to achieve particularly at an alveolar level where gas exchange occurs; however this amphilicity has been reached by mimicking human genome rather than by its own developmental sophistication. There is a wide range of therapeutic options for map kinase regulations. Some antimalarials and low dose aspirin even have demonstrated modest activity and according to recent news they have helped in difficult cases but prompt antiviral management should be addressed prior to the skyrocketing immune phase where the body may fail to recognise itself and self-attack. By targeting the virus initially the map kinase may react non-disproportionately.

scholarly journals Low dose aspirin prevents duodenoesophageal reflux induced mucosal changes in wistar rat esophagus by MAP kinase mediated pathways

2012 ◽  
Vol 10 (2) ◽  
pp. 73-79 ◽  
Author(s):  
Ben Selvan ◽  
Anup Ramachandran ◽  
Anu Korula ◽  
G. Jayakumar Amirtharaj ◽  
Kavithapriya Kettimuthu ◽  
...  
Keyword(s):  
Map Kinase ◽  
Low Dose ◽  
Wistar Rat ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Mucosal Changes

Alert Issued on Low-Dose Aspirin + Ibuprofen

2006 ◽  
Vol 34 (10) ◽  
pp. 8
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin

Investigation of the Interaction of Blood Platelets with the Coagulation System at the Site of Plug Formation In Vivo in Man - Effect of Low-Dose Aspirin

1987 ◽  
Vol 57 (01) ◽  
pp. 062-066 ◽  
Author(s):  
P A Kyrle ◽  
J Westwick ◽  
M F Scully ◽  
V V Kakkar ◽  
G P Lewis
Keyword(s):  
Platelet Activation ◽  
Thrombin Generation ◽  
Low Dose ◽  
Bleeding Time ◽  
Blood Platelets ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Plug Formation ◽  
Granule Release

SummaryIn 7 healthy volunteers, formation of thrombin (represented by fibrinopeptide A (FPA) generation, α-granule release (represented by β-thromboglobulin [βTG] release) and the generation of thromboxane B2 (TxB2) were measured in vivo in blood emerging from a template bleeding time incision. At the site of plug formation, considerable platelet activation and thrombin generation were seen within the first minute, as indicated by a 110-fold, 50-fold and 30-fold increase of FPA, TxB2 and PTG over the corresponding plasma values. After a further increase of the markers in the subsequent 3 minutes, they reached a plateau during the fourth and fifth minute. A low-dose aspirin regimen (0.42 mg.kg-1.day-1 for 7 days) caused >90% inhibition of TxB2formation in both bleeding time blood and clotted blood. At the site of plug formation, a-granule release was substantially reduced within the first three minutes and thrombin generation was similarly inhibited. We conclude that (a) marked platelet activation and considerable thrombin generation occur in the early stages.of haemostasis, (b) α-granule release in vivo is partially dependent upon cyclo-oxygenase-controlled mechanisms and (c) thrombin generation at the site of plug formation is promoted by the activation of platelets.

Increased Thromboxane Biosynthesis in Essential Thrombocythemia

1995 ◽  
Vol 74 (05) ◽  
pp. 1225-1230 ◽  
Author(s):  
Bianca Rocca ◽  
Giovanni Ciabattoni ◽  
Raffaele Tartaglione ◽  
Sergio Cortelazzo ◽  
Tiziano Barbui ◽  
...  
Keyword(s):  
Platelet Count ◽  
Platelet Activation ◽  
Essential Thrombocythemia ◽  
Therapeutic Strategy ◽  
Low Dose ◽  
Thrombotic Risk ◽  
Dose Aspirin ◽  
Gender And Age ◽  
Low Dose Aspirin

SummaryIn order to investigate the in vivo thromboxane (TX) biosynthesis in essential thromboeythemia (ET), we measured the urinary exeretion of the major enzymatic metabolites of TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 in 40 ET patients as well as in 26 gender- and age-matched controls. Urinary 11-dehydro-TXB2 was significantly higher (p <0.001) in thrombocythemic patients (4,063 ± 3,408 pg/mg creatinine; mean ± SD) than in controls (504 ± 267 pg/mg creatinine), with 34 patients (85%) having 11-dehydro-TXB2 >2 SD above the control mean. Patients with platelet number <1,000 × 109/1 (n = 25) had significantly higher (p <0.05) 11 -dehydro-TXB2 excretion than patients with higher platelet count (4,765 ± 3,870 pg/mg creatinine, n = 25, versus 2,279 ± 1,874 pg/mg creatinine, n = 15). Average excretion values of patients aging >55 was significantly higher than in the younger group (4,784 ± 3,948 pg/mg creatinine, n = 24, versus 2,405 ± 1,885 pg/mg creatinine, n = 16, p <0.05). Low-dose aspirin (50 mg/d for 7 days) largely suppressed 11-dehydro-TXB2 excretion in 7 thrombocythemic patients, thus suggesting that platelets were the main source of enhanced TXA2 biosynthesis. The platelet count-corrected 11-dehydro-TXB2 excretion was positively correlated with age (r = 0.325, n = 40, p <0.05) and inversely correlated with platelet count (r = -0.381, n = 40, p <0.05). In addition 11 out of 13 (85%) patients having increased count-corrected 11-dehydro-TXB2 excretion, belonged to the subgroup with age >55 and platelet count <1,000 × 1099/1. We conclude that in essential thrombocythemia: 1) enhanced 11-dehydro-TXB2 excretion largely reflects platelet activation in vivo;2) age as well as platelet count appear to influence the determinants of platelet activation in this setting, and can help in assessing the thrombotic risk and therapeutic strategy in individual patients.

Low-dose aspirin for the prevention of preterm delivery

2020 ◽  
Author(s):  
Hoffman MK ◽  
Goudar SS ◽  
Kodkany BS ◽  
Metgud M ◽  
Somannavar M ◽  
...  
Keyword(s):  
Preterm Delivery ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin

Prevention of pre-eclampsia with low dose aspirin in primigravida

2020 ◽  
Vol 9 (1) ◽  
pp. 28-32
Author(s):  
Oreekha Amin ◽  
Nasira Tasnim ◽  
Shumaila Naeem
Keyword(s):  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin
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