scholarly journals Differential expression of transient receptor potential cation channel subfamily C member 4 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Clinical Problem ◽  
Cation Channel ◽  
Normal Endometrium ◽  
Black Patients ◽  
Endometrial Tumor ◽  
Transient Receptor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published and public microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified transient receptor potential cation channel subfamily C member 4, encoded by TRPC4, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. TRPC4 was expressed at significantly lower levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of TRPC4 was correlated with overall survival in black patients with low mutational burden. TRPC4 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of diazepam binding inhibitor, acyl-CoA binding protein in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Binding Protein ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified diazepam binding inhibitor, acyl-CoA binding protein, encoded by DBI, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DBI was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DBI was correlated with recurrence-free survival in black patients with low mutational burden. DBI may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of MLX, MAX dimerization protein in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified MLX, MAX dimerization protein, encoded by MLX, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. MLX was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of MLX was correlated with recurrence-free survival in black patients with low mutational burden. MLX may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of dihydrolipoamide S-acetyltransferase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified dihydrolipoamide S-acetyltransferase, encoded by DLAT, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DLAT was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DLAT was correlated with overall survival in black patients with low mutational burden. DLAT may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of mitochondrial phosphoenolpyruvate carboxykinase 2 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified phosphoenolpyruvate carboxykinase 2, mitochondrial, encoded by PCK2, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PCK2 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PCK2 was correlated with recurrence-free survival in black patients with high mutational burden. PCK2 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of oxysterol binding protein like 3 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Binding Protein ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Oxysterol Binding Protein ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified oxysterol binding protein like 3, encoded by OSBPL3, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. OSBPL3 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of OSBPL3 was correlated with recurrence-free survival in black patients with low mutational burden. OSBPL3 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of pyrophosphatase (inorganic) 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified pyrophosphatase (inorganic) 1, encoded by PPA1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PPA1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PPA1 was correlated with recurrence-free survival in black patients with low mutational burden. PPA1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of desumoylating isopeptidase 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified desumoylating isopeptidase 1, encoded by DESI1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DESI1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DESI1 was correlated with recurrence-free survival in black patients with high mutational burden. DESI1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of progestin and adipoQ receptor family member 4 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Family Member ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression ◽  
Receptor Family

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified progestin and adipoQ receptor family member 4, encoded by PAQR4, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PAQR4 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PAQR4 was correlated with overall survival in black patients with low mutational burden. PAQR4 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of glutamic-oxaloacetic transaminase 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Glutamic Oxaloacetic Transaminase ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified glutamic-oxaloacetic transaminase 1, encoded by GOT1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. GOT1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of GOT1 was correlated with recurrence-free survival in black patients with low mutational burden. GOT1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of ubiquinol-cytochrome c reductase complex III subunit VII in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Cytochrome C ◽  
Clinical Problem ◽  
Complex Iii ◽  
Normal Endometrium ◽  
Cytochrome C Reductase ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified ubiquinol-cytochrome c reductase complex III subunit VII, encoded by UQCRQ, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. UQCRQ was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of UQCRQ was correlated with overall survival in black patients with high mutational burden. UQCRQ may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

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