Imprinted gene in the Prader-Willi syndrome region (IPW) is differentially expressed in the brains of patients with psychotic disorders.
Keyword(s):
We used published and public microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified Imprinted gene in the Prader-Willi syndrome region (IPW) (3) as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia as well as in the parvalbumin-positive layer 3 neurons of the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. IPW likely encodes a non-coding RNA (4, 5) and is a regulator of the imprinted DLK1-DIO3 locus (4); we found that IPW was expressed at significantly higher levels in the dorsolateral prefrontal cortex of patients with psychotic disorders.
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