PAX8 is differentially expressed in the brains of patients with psychotic disorders.
Keyword(s):
We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified the paired box-containing transcription factor PAX8 as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. In neurons of the dorsolateral prefrontal cortex, PAX8 was expressed at significantly higher levels in patients with psychotic disorders.
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