RNase L is differentially expressed in the brains of patients with psychotic disorders.
Keyword(s):
Rnase L
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We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified the gene encoding the endoribonuclease RNase L as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. In neurons of the dorsolateral prefrontal cortex, RNase L was expressed at significantly lower levels in patients with psychotic disorders.
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