Peroxiredoxin 5 (PRDX5) is differentially expressed in the brains of patients with psychotic disorders.
Keyword(s):
We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified PRDX53 as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia as well as in the parvalbumin-positive layer 3 neurons of the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. The brain tissues of patients with psychotic disorders expressed significantly lower levels of PRDX5 than that of non-affected control subjects. PRDX5 may be relevant to the biology of schizophrenia and related psychotic disorders.
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