DDX19B is differentially expressed in the brains of patients with psychotic disorders.

Psychotic Disorders ◽

Dorsolateral Prefrontal ◽

Significant Gene ◽

The Brain

We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified PRDX53 as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia as well as in the parvalbumin-positive layer 3 neurons of the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. The brain tissues of patients with psychotic disorders expressed significantly lower levels of PRDX5 than that of non-affected control subjects. PRDX5 may be relevant to the biology of schizophrenia and related psychotic disorders.

NDUFV1 is differentially expressed in the brains of patients with psychotic disorders.

10.31219/osf.io/6q95x ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Gene Expression ◽

Prefrontal Cortex ◽

Microarray Data ◽

Psychotic Disorders ◽

Dorsolateral Prefrontal ◽

We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified NDUFV1 as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. In neurons of the dorsolateral prefrontal cortex, NDUFV1 was expressed at significantly lower levels in patients with psychotic disorders.

RBMXL1 is differentially expressed in the brains of patients with psychotic disorders.

10.31219/osf.io/hv5n3 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Gene Expression ◽

Prefrontal Cortex ◽

Microarray Data ◽

Psychotic Disorders ◽

Dorsolateral Prefrontal ◽

We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified RBMXL1 as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. In neurons of the dorsolateral prefrontal cortex, RBMXL1 was expressed at significantly lower levels in patients with psychotic disorders.

PAX8 is differentially expressed in the brains of patients with psychotic disorders.

10.31219/osf.io/hax7v ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Gene Expression ◽

Transcription Factor ◽

Prefrontal Cortex ◽

Microarray Data ◽

Psychotic Disorders ◽

Dorsolateral Prefrontal ◽

We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified the paired box-containing transcription factor PAX8 as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. In neurons of the dorsolateral prefrontal cortex, PAX8 was expressed at significantly higher levels in patients with psychotic disorders.

NTRK2 is differentially expressed in the brains of patients with psychotic disorders.

10.31219/osf.io/va4ur ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Gene Expression ◽

Bipolar Disorder ◽

Prefrontal Cortex ◽

Microarray Data ◽

Psychotic Disorders ◽

Dorsolateral Prefrontal ◽

Significant Gene ◽

Psychotic Bipolar Disorder

We used published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified NTRK2 as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia as well as in the dorsolateral prefrontal cortex of patients with schizophrenia and psychotic bipolar disorder. NTRK2 expression was significantly higher in the dorsolateral prefrontal cortex of patients with psychotic disorders.

RNase L is differentially expressed in the brains of patients with psychotic disorders.

10.31219/osf.io/m6ydx ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Gene Expression ◽

Prefrontal Cortex ◽

Microarray Data ◽

Psychotic Disorders ◽

Rnase L ◽

Gene Encoding ◽

Dorsolateral Prefrontal ◽

We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified the gene encoding the endoribonuclease RNase L as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. In neurons of the dorsolateral prefrontal cortex, RNase L was expressed at significantly lower levels in patients with psychotic disorders.

GABARAPL1 is differentially expressed in the brains of patients with psychotic disorders.

10.31219/osf.io/kygn5 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Prefrontal Cortex ◽

Microarray Data ◽

Psychotic Disorders ◽

Aminobutyric Acid ◽

Receptor Associated Protein ◽

Dorsolateral Prefrontal ◽

Significant Gene ◽

The Brain

We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified the 𝛄-aminobutyric acid receptor-associated protein-like 1 GABARAPL13 as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia as well as in the parvalbumin-positive layer 3 neurons of the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. The brain tissues of patients with psychotic disorders expressed significantly lower levels of GABARAPL1 than that of non-affected control subjects. GABARAPL1 may be relevant to the biology of schizophrenia and related psychotic disorders.

Imprinted gene in the Prader-Willi syndrome region (IPW) is differentially expressed in the brains of patients with psychotic disorders.

10.31219/osf.io/f2zwy ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Prefrontal Cortex ◽

Microarray Data ◽

Psychotic Disorders ◽

Prader Willi Syndrome ◽

Imprinted Gene ◽

Non Coding Rna ◽

Dorsolateral Prefrontal ◽

We used published and public microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified Imprinted gene in the Prader-Willi syndrome region (IPW) (3) as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia as well as in the parvalbumin-positive layer 3 neurons of the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. IPW likely encodes a non-coding RNA (4, 5) and is a regulator of the imprinted DLK1-DIO3 locus (4); we found that IPW was expressed at significantly higher levels in the dorsolateral prefrontal cortex of patients with psychotic disorders.

The superoxide dismutase 1 (SOD1) is differentially expressed in the brains of patients with psychotic disorders.

10.31219/osf.io/ct9sv ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Superoxide Dismutase ◽

Prefrontal Cortex ◽

Microarray Data ◽

Psychotic Disorders ◽

Superoxide Dismutase 1 ◽

Gene Encoding ◽

Dorsolateral Prefrontal ◽

We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified the gene encoding the superoxide dismutase 1 (SOD1) as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia and schizoaffective disorder. In neurons of the dorsolateral prefrontal cortex from patients with psychotic disorders, SOD1 expression was significantly decreased.

Phospholipase C beta2 (PLCB2) is differentially expressed in the dorsolateral prefrontal cortex of patients with psychotic disorders.

10.31234/osf.io/h452e ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Gene Expression ◽

Prefrontal Cortex ◽

Phospholipase C ◽

Psychotic Disorders ◽

Dorsolateral Prefrontal ◽

Microarray Datasets ◽

And Control ◽

Psychotic Bipolar Disorder

We mined two microarray datasets (published or public) (1, 2) to identify the most significant changes in gene expression in the brains of patients with psychotic disorders. We found that isoform 2 of phospholipase C beta (PLCB2) was among the genes most differentially expressed in the dorsolateral prefrontal cortex (DLPFC) of patients with schizophrenia and psychotic bipolar disorder (1). In a separate dataset (2), PLCB2 was again among the genes whose expression changed most significantly when comparing parvalbumin-positive layer 3 neurons from the DLPFC between patients with schizophrenia and schizoaffective disorder and control subjects. Multiple studies have documented dysregulated PLCB1 expression in the brains of patients with schizophrenia, including in the dorsolateral prefrontal cortex (3-6). These data suggest that PLCB2 expression may also be perturbed in the brains of patients with psychotic disorders.