CAR T cell research has quickly advanced from the bench to the clinic and back. The results of the trials have revealed new mechanisms

CAR T cell research has fast progressed into the clinic and now back to the bench, with trial outcomes exposing new mechanisms of efficacy, toxicity, and resistance, and sparking the hunt for additional targets, clarification of signaling systems, and application of newer technology. CAR design, transduction methods, and cell type selection are all predicted to improve responses and change therapy for patients with a variety of malignancies.