FBXL8 is differentially expressed and transcriptionally induced in MERS coronavirus infection.

Human Cell Line ◽

Human Cells ◽

Sars Coronavirus ◽

Lack Of Information ◽

Mammalian Tissues ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined three independent datasets (3-5), public (3) and published (4, 5) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus, human coronavirus (HCoV) and SARS coronavirus to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified MAP3K8, also known as COT and Tpl-2 (6-8) as a conserved differentially expressed gene following coronavirus infection in primary human cells, in a human cell line, and in the lungs of infected ferrets. MAP3K8 expression dramatically decreased within 12-24 hours of coronavirus infection, both in the lungs of ferrets infected with SARS coronavirus and in primary human microvascular endothelial cells infected with MERS coronavirus. MAP3K8 may be involved in the cellular response to COVID19 infection or a host cell vulnerability, exploited by coronaviruses.

The La ribonucleoprotein domain family member 6, LARP6 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/wgdy3 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Family Member ◽

Cellular Response ◽

Domain Family ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified the La ribonucleoprotein domain family member 6 (LARP6) as a conserved differentially expressed gene following coronavirus infection. LARP6 may be involved in the cellular response to COVID19 infection.

IFI44 is differentially expressed in models of coronavirus infection in vivo.

10.31219/osf.io/jdw98 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Host Cell ◽

Cellular Response ◽

Distress Syndrome ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent published datasets (3-4), containing transcriptome data from infection models of the severe acute respiratory distress syndrome SARS coronavirus in mice and in ferrets to discover genes that are differentially expressed in coronaviruses in vivo and identify potential therapeutic targets and host cell vulnerabilities. We identified IFI44 as a conserved differentially expressed gene following coronavirus infection in the blood of infected ferrets and in the lungs of infected mice. IFI44 may be involved in the cellular response to COVID19 infection or a host cell vulnerability, exploited by coronaviruses.

TRIB1 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/yjrh9 ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Cellular Response ◽

Transcriptome Data ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The World ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified tribbles homolog 1, TRIB1 as a conserved differentially expressed gene following coronavirus infection. TRIB1 may be involved in the cellular response to COVID19 infection.

The DNA Damage Inducible Transcript DDIT3 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/dfcbv ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Dna Damage ◽

Cellular Response ◽

Transcriptome Data ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified the DNA Damage Inducible Transcript DDIT3 as a conserved differentially expressed gene following coronavirus infection. DDIT3 may be involved in the cellular response to COVID19 infection.

The methylenetetrahydrofolate dehydrogenase/cyclohydrolase MTHFD2 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/qt2rz ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Cellular Response ◽

Transcriptome Data ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

Methylenetetrahydrofolate Dehydrogenase ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified the methylenetetrahydrofolate dehydrogenase/cyclohydrolase MTHFD2 as a conserved differentially expressed gene following coronavirus infection. MTHFD2 may be involved in the cellular response to COVID19 infection.

The transcription factor ZBTB43 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/jhnfv ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Transcription Factor ◽

Cellular Response ◽

Transcriptome Data ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified the transcription factor ZBTB43 as a conserved differentially expressed gene following coronavirus infection. ZBTB43 may be involved in the cellular response to COVID19 infection.

SSX2 is differentially expressed in models of MERS coronavirus infection.

10.31219/osf.io/8w62r ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Human Cells ◽

Sars Coronavirus ◽

Human Coronavirus ◽

Interacting Protein ◽

Lack Of Information ◽

Mammalian Tissues ◽

Coronavirus Infection ◽

Human Coronavirus 229E

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined multiple independent public (3) or published datasets (4-8) containing transcriptome data from infection models of human coronavirus 229E, the severe acute respiratory syndrome (SARS) coronavirus and Middle East respiratory syndrome (MERS) coronavirus to discover genes whose differential expression was conserved across the coronavirus family. We identified SSX2 (9) as a differentially expressed gene following infection of human cells specifically with two types of MERS coronaviruses. and not after infection of human cells with human coronavirus 229E, or and in the lungs of mice and ferrets infected with SARS coronavirus. An SSX2 interacting protein, SSX2IP, was among the genes most differentially expressed in the ferret blood after infection with SARS coronavirus. The expression of SSX2 is modulated to a degree unlike most any other gene following infection with MERS coronaviruses.

C3ORF19/CCDC174 is differentially expressed and transcriptionally induced in models of coronavirus infection.

10.31219/osf.io/2w7ap ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Cellular Response ◽

Transcriptome Data ◽

Human Coronavirus ◽

Lack Of Information ◽

Infection Models ◽

Mammalian Tissues ◽

The World ◽

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified C3ORF19, also known as CCDC174 as a conserved differentially expressed gene following coronavirus infection. C3ORF19 may be involved in the cellular response to COVID19 infection.

GEM/Kir is differentially expressed in multiple models of coronavirus infection.

10.31219/osf.io/8nzbq ◽

2020 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Human Cells ◽

Sars Coronavirus ◽

Human Coronavirus ◽

Lack Of Information ◽

Mammalian Tissues ◽

Coronavirus Infection ◽

Novel Coronavirus ◽

Human Coronavirus 229E

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined multiple independent public (3) or published datasets (4-7) containing transcriptome data from infection models of human coronavirus 229E, the severe acute respiratory syndrome (SARS) coronavirus and Middle East respiratory syndrome (MERS) coronavirus to discover genes whose differential expression was conserved across the coronavirus family. We identified the GTP binding protein overexpressed in skeletal muscle, GEM (8), also known as Kir, as a differentially expressed gene following infection of human cells with two types of MERS coronavirus, after infection of human cells with human coronavirus 229E, and in the lungs of mice and ferrets infected with SARS coronavirus. GEM induction after viral infection appears to be conserved across the coronavirus family and may be found in patients infected with the novel coronavirus SARS-CoV-2.