Lost in Translation – Crossing the Valley of Death across preclinical and clinical divide
Keyword(s):
A rift that has opened up between basic research (bench) and clinical research and patients (bed) who need their new treatments, diagnostics and prevention, and this rift is widening and getting deeper. The crisis involving the “translation” of basic scientific findings in a laboratory setting to human applications and potential treatments or biomarkers for disease is widely recognized both in academia and industry. Despite the attempts that have been made to mitigate this problem, the high attrition rates of drug development and the problem with reproducibility and translatability of preclinical findings to human applications remain a fact and the return on the investment has been limited in terms of clinical impact.
2019 ◽
Vol 4
(1)
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2017 ◽
Vol 54
(1)
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pp. 855-856
Keyword(s):
2004 ◽
Vol 10
(9)
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pp. 1045-1055
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2019 ◽
Vol 15
(5)
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pp. 472-485
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2009 ◽
Vol 86
(3)
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pp. 332-335
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2004 ◽
Vol 37
(1)
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pp. 19-24
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Keyword(s):