Suicide gene therapy may be effective in the treatment of malignant glioma

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Stem Cell ◽  
Malignant Glioma ◽  
Viral Vectors ◽  
Glioma Cells ◽  
Suppressor Cells ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Survival Ratio

Suicide gene therapy has a long history, and its effectiveness is now under investigation. The bystander death effect therapeutic strategy proved successful in treating malignant glioma; nevertheless, non-replicating viral vectors may not be able to cover a large invading region of glioma cells. Tumor-trophic stem cell migration and viral replication capacities have the potential to overcome the refractory mechanisms of malignant glioma. Surprisingly, the time to response (partial or total response) was delayed for more than 6 months after the initial Toca 511 treatment, reflecting a stronger antitumor immune response. Immunosuppressive cells such myeloid-derived suppressor cells and tumor-associated macrophages were found to be lower in human glioblastoma tissues after treatment. These mechanisms may have a long-term impact on people with malignant glioma. NSCs and MSCs, for example, might be employed to cover glioma cells' more broad invading areas. However, we must investigate which brain stem cells are the most suited. More study is needed to confirm the migratory potential and survival ratio of the implanted stem cells in the brain utilizing comparative analysis. Suicide gene therapy using stem cell migratory capability and/or viral replicating capability for malignant glioma may recapture the spotlight.

scholarly journals Stem Cell Based Gene Therapy in Prostate Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Jae Heon Kim ◽  
Hong Jun Lee ◽  
Yun Seob Song
Keyword(s):  
Prostate Cancer ◽  
Stem Cells ◽  
Gene Therapy ◽  
Stem Cell ◽  
Viral Vector ◽  
Cytosine Deaminase ◽  
Suicide Gene ◽  
Genetically Engineered ◽  
Suicide Gene Therapy ◽  
Cytotoxic Agents

Current prostate cancer treatment, especially hormone refractory cancer, may create profound iatrogenic outcomes because of the adverse effects of cytotoxic agents. Suicide gene therapy has been investigated for the substitute modality for current chemotherapy because it enables the treatment targeting the cancer cells. However the classic suicide gene therapy has several profound side effects, including immune-compromised due to viral vector. Recently, stem cells have been regarded as a new upgraded cellular vehicle or vector because of its homing effects. Suicide gene therapy using genetically engineered mesenchymal stem cells or neural stem cells has the advantage of being safe, because prodrug administration not only eliminates tumor cells but consequently kills the more resistant therapeutic stem cells as well. The attractiveness of prodrug cancer gene therapy by stem cells targeted to tumors lies in activating the prodrug directly within the tumor mass, thus avoiding systemic toxicity. Therapeutic achievements using stem cells in prostate cancer include the cytosine deaminase/5-fluorocytosine prodrug system, herpes simplex virus thymidine kinase/ganciclovir, carboxyl esterase/CPT11, and interferon-beta. The aim of this study is to review the stem cell therapy in prostate cancer including its proven mechanisms and also limitations.

scholarly journals The war against cancer: Suicide gene therapy

2016 ◽  
Vol 2 (3) ◽  
pp. 139
Author(s):  
Muzeyyen Izmirli ◽  
Dilara Sonmez ◽  
Bulent Gogebakan
Keyword(s):  
Gene Therapy ◽  
Cytochrome P450 ◽  
Side Effects ◽  
Cancer Cells ◽  
Thymidine Kinase ◽  
Viral Vectors ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Kinase Gene ◽  
Cancer Society

<p>The National Cancer Institute and the American Cancer Society announced that 1.6 million new cancer cases are projected to occur in the USA in 2016. One of the most innovative approaches against cancer is suicide gene therapy, in which suicide-inducing transgenes are introduced into cancer cells. When cancer treatments target the total elimination of tumor cells, there will be no side effects for normal cells. Cancer tissues are targeted through various targeted transport methods, followed by tissue-specific enzymes converting a systemically suitable prodrug into an active drug in the tumor. Suicidal genes are delivered by transporters, such as viral and non-viral vectors, into cancer cells. Suicide gene therapeutic strategies currently pursued are herpes simplex virus thymidine kinase gene with prodrug ganciclovir, cytosine deaminase gene, carboxyl esterase/irinotecan, varicella zoster virus thymidine kinase/6-methoxypurine arabinonucleoside, nitroreductase Nfsb/5-(aziridin-1-yl)-2,4-dinitrobenzamide, carboxypeptidase G2/4-[(2-chloroethyl)(2- mesyloxyethyl)amino]benzoyl-L-glutamic acid, cytochrome p450-isofosfamide, and cytochrome p450-cyclophosphamide. The goal of this review is to summarize the different suicide gene systems and gene delivery vectors addressed to cancer cells, with a particular emphasis on recently developed systems. Finally, we briefly describe the advantageous clinical applications and potential side effects of suicide gene therapy. </p>

Nicotine does not affect stem cell properties requisite for suicide gene therapy against glioma

2020 ◽  
Vol 42 (10) ◽  
pp. 818-827
Author(s):  
Hiroaki Kenmochi ◽  
Tomohiro Yamasaki ◽  
Shinichiro Koizumi ◽  
Tetsuro Sameshima ◽  
Hiroki Namba
Keyword(s):  
Gene Therapy ◽  
Stem Cell ◽  
Suicide Gene ◽  
Suicide Gene Therapy

scholarly journals Prodrug suicide gene therapy for cancer targeted intracellular by mesenchymal stem cell exosomes

2018 ◽  
Vol 144 (4) ◽  
pp. 897-908 ◽  
Author(s):  
Ursula Altanerova ◽  
Jana Jakubechova ◽  
Katarina Benejova ◽  
Petra Priscakova ◽  
Martin Pesta ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Suicide Gene ◽  
Suicide Gene Therapy

Clinical Impact of Suicide Gene Therapy in Allogeneic Hematopoietic Stem Cell Transplantation

2010 ◽  
Vol 21 (3) ◽  
pp. 241-250 ◽  
Author(s):  
Maria Teresa Lupo-Stanghellini ◽  
Elena Provasi ◽  
Attilio Bondanza ◽  
Fabio Ciceri ◽  
Claudio Bordignon ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Suicide Gene ◽  
Clinical Impact ◽  
Suicide Gene Therapy ◽  
Hematopoietic Stem
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