scholarly journals Skill reconsolidation does not operate at a rapid micro-timescale level

2022 ◽  
Author(s):  
Jasmine Herszage ◽  
Marlene Bönstrup ◽  
Leonardo G Cohen ◽  
Nitzan Censor

Abundant evidence shows that consolidated memories are susceptible to modifications following their reactivation through reconsolidation. Processes of memory consolidation and reconsolidation have been commonly documented after hours or days. Motivated by studies showing rapid consolidation in early stages of skill acquisition, here we asked whether skill memories are susceptible to modifications through rapid reconsolidation, even at initial stages of learning. In a set of experiments, we collected crowdsourced online motor sequence data to test whether post-reactivation interference and enhancement occur through rapid reconsolidation. Results indicate that memories forming during early learning are not susceptible to interference nor to enhancement within a rapid reconsolidation time window, relative to control conditions. This set of evidence suggests that memory reconsolidation might be dependent on consolidation at the macro-timescale level, requiring hours or days to occur.

Nature ◽  
2003 ◽  
Vol 425 (6958) ◽  
pp. 616-620 ◽  
Author(s):  
Matthew P. Walker ◽  
Tiffany Brakefield ◽  
J. Allan Hobson ◽  
Robert Stickgold

2014 ◽  
Vol 62 (1) ◽  
pp. 89-99 ◽  
Author(s):  
Carla D. Cash ◽  
Sarah E. Allen ◽  
Amy L. Simmons ◽  
Robert A. Duke

This study was designed to investigate the extent to which the presentation of an auditory model prior to learning a novel melody affects performance during active practice and the overnight consolidation of procedural memory. During evening training sessions, 32 nonpianist musicians practiced a 13-note keyboard melody with their left (nondominant) hand in twelve 30-s practice intervals separated by 30-s rest intervals. Participants were instructed to play the sequence “as quickly, accurately, and evenly as possible.” Approximately half the participants, prior to the first practice interval, listened to 10 repetitions of the target melody played at 552 tones per minute (half note = 138). All participants were tested on the target melody the following morning, approximately 12 hr after training, in three 30-s blocks separated by 30-s rest intervals. Performance was measured in terms of the mean number of correct key presses per 30-s block (CKP/B). Consistent with previous research, participants made considerable improvements in CKP/B during the evening training sessions and between the end of training and the morning test sessions. Learners who listened to the model made significantly larger gains in performance during training and between the end of training and test than did those who did not hear the model.


1994 ◽  
Vol 11 (2) ◽  
pp. 214-235 ◽  
Author(s):  
Cheryl Missiuna

Children with developmental coordination disorder (DCD) demonstrate coordination difficulties during the learning of novel motor skills; no previous studies, however, have investigated their ability to learn and then generalize a new movement. This study compared 24 young children with DCD with 24 age-matched control children (AMC) during the early stages of learning a simple aiming task. Children with DCD were found to perform more poorly than their peers on measures of acquired motor skill, and to react and move more slowly at every level of task performance. The effect of age and its relationship to practice of the task was also different within each group. The groups did not differ, however, in their rate of learning, or in the extent to which they were able to generalize the learned movement. Children with DCD sacrificed more speed than the AMC group when aiming at a small target, but the effects of amplitude and directional changes were quite similar for each group. The implications of these findings are discussed.


2010 ◽  
Vol 104 (5) ◽  
pp. 2603-2614 ◽  
Author(s):  
Michael A. Nitsche ◽  
Michaela Jakoubkova ◽  
Nivethida Thirugnanasambandam ◽  
Leonie Schmalfuss ◽  
Sandra Hullemann ◽  
...  

Motor learning and memory consolidation require the contribution of different cortices. For motor sequence learning, the primary motor cortex is involved primarily in its acquisition. Premotor areas might be important for consolidation. In accordance, modulation of cortical excitability via transcranial DC stimulation (tDCS) during learning affects performance when applied to the primary motor cortex, but not premotor cortex. We aimed to explore whether premotor tDCS influences task performance during motor memory consolidation. The impact of excitability-enhancing, -diminishing, or placebo premotor tDCS during rapid eye movement (REM) sleep on recall in the serial reaction time task (SRTT) was explored in healthy humans. The motor task was learned in the evening. Recall was performed immediately after tDCS or the following morning. In two separate control experiments, excitability-enhancing premotor tDCS was performed 4 h after task learning during daytime or immediately before conduction of a simple reaction time task. Excitability-enhancing tDCS performed during REM sleep increased recall of the learned movement sequences, when tested immediately after stimulation. REM density was enhanced by excitability-increasing tDCS and reduced by inhibitory tDCS, but did not correlate with task performance. In the control experiments, tDCS did not improve performance. We conclude that the premotor cortex is involved in motor memory consolidation during REM sleep.


2003 ◽  
Vol 53 (2) ◽  
pp. 89-112 ◽  
Author(s):  
Hans-Joachim Bischof

Abstract Sexual imprinting is an early learning process by which a young animal acquires information which will help in choosing a sexual partner. It consists of two separate phases, an acquisition phase where features of the social environment are learnt, and a stabilisation phase in which, guided by the previously acquired social information, a preference for a sexual partner is established and stabilised, such that it cannot be altered subsequently. The stabilisation process is short and can be controlled experimentally. This review summarises research on the neural events accompanying consolidation in those brain areas which have previously been identified as important for imprinting. It shows that the period during which consolidation can occur can be shifted only within a certain time window, and demonstrates the fast adjustment of spine densities within the imprinting areas after consolidation has started. It further suggests that long term potentiation (LTP) and long term depression (LTD)-like mechanisms may be involved in this learning process, and that the immediate early genes ZENK and c-fos are expressed within the relevant imprinting areas in the course of consolidation. Evidence is presented for a prominent role of the lateral neostriatum in the imprinting process, and also for the involvement of the hippocampus in this type of early learning.


SLEEP ◽  
2021 ◽  
Author(s):  
Ullrich Bartsch ◽  
Laura J Corbin ◽  
Charlotte Hellmich ◽  
Michelle Taylor ◽  
Kayleigh E Easey ◽  
...  

Abstract The rs1344706 polymorphism in ZNF804A is robustly associated with schizophrenia and schizophrenia is, in turn, associated with abnormal non-rapid eye movement (NREM) sleep neurophysiology. To examine whether rs1344706 is associated with intermediate neurophysiological traits in the absence of disease, we assessed the relationship between genotype, sleep neurophysiology, and sleep-dependent memory consolidation in healthy participants. We recruited healthy adult males with no history of psychiatric disorder from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Participants were homozygous for either the schizophrenia-associated ‘A’ allele (N=22) or the alternative ‘C’ allele (N=18) at rs1344706. Actigraphy, polysomnography (PSG) and a motor sequence task (MST) were used to characterize daily activity patterns, sleep neurophysiology and sleep-dependent memory consolidation. Average MST learning and sleep-dependent performance improvements were similar across genotype groups, albeit more variable in the AA group. During sleep after learning, CC participants showed increased slow-wave (SW) and spindle amplitudes, plus augmented coupling of SW activity across recording electrodes. SW and spindles in those with the AA genotype were insensitive to learning, whilst SW coherence decreased following MST training. Accordingly, NREM neurophysiology robustly predicted the degree of overnight motor memory consolidation in CC carriers, but not in AA carriers. We describe evidence that rs1344706 polymorphism in ZNF804A is associated with changes in the coordinated neural network activity that supports offline information processing during sleep in a healthy population. These findings highlight the utility of sleep neurophysiology in mapping the impacts of schizophrenia-associated common genetic variants on neural circuit oscillations and function.


2012 ◽  
Vol 26 (1) ◽  
pp. 109-121 ◽  
Author(s):  
Dinko Kranjac ◽  
Kristina A. McLinden ◽  
Lauren E. Deodati ◽  
Mauricio R. Papini ◽  
Michael J. Chumley ◽  
...  

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A44-A44
Author(s):  
L B Ray ◽  
V Sergeeva ◽  
J Viczko ◽  
A M Owen ◽  
S M Fogel

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