scholarly journals Controlled Internal Drug Release (CIDR) Based Hormonal Protocols Effect upon Estrus Response and Pregnancy Outcome in Anestrous Cows

2019 ◽  
Vol 36 ◽  
pp. 46-52
Author(s):  
A. K. Sah ◽  
Y. R Pandeya ◽  
L. R Pathak ◽  
G. Gautam
Keyword(s):  
Drug Release ◽  
Pregnancy Outcome ◽  
Artificial Insemination ◽  
Research Programme ◽  
Fixed Time ◽  
Research Findings ◽  
Expression Rate ◽  
Estrus Response ◽  
Jersey Cows ◽  
Poor Pregnancy Outcome

 Controlled internal drug release (CIDR) based hormonal protocols CoSynch + CIDR, OvSynch + CIDR and CIDR + PGF2α were applied to 25 crossbred anestrous Holstein and Jersey cows to improve the fertility at the farm of National Cattle Research Programme, Rampur, Chitwan. All three protocols were found equally effective (P>0.05) with 100% estrus expression rate, out of which, 80% (8/10), 85.7% (6/7) and 75% (6/8) had estrus expression with well cervix open at fixed time artificial insemination in CoSynch + CIDR, OvSynch + CIDR and CIDR + PGF2α protocols respectively and rest had estrus expression with partial cervix open. Statistically non-significant (P>0.05) pregnancy outcome that is 14.3 % (1/7) in CIDR+PGF2α group and 12.5 % (1/8) in OvSynch group while none in CoSynch + CIDR group were pregnant following fixed time artificial insemination. Poor pregnancy outcome of the anestrous cows in all protocols might not only have hormonal problem but also could have various other reasons which was beyond the objective of this research findings. Hence, study concludes anestrous cows respond well to the CIDR based hormonal protocols to revive the estrus.  

24 The Effects of Vaginal pH on Fertility of Beef Cows and Heifers Enrolled in the 7-d Co-synch + Controlled Internal Drug Release (CIDR) Protocol

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 9-10
Author(s):  
Nicholas W Wege Dias ◽  
Stefania Pancini ◽  
Hannah Haines ◽  
Vitor R G Rodrigues Gomes Mercadante
Keyword(s):  
Drug Release ◽  
Pregnancy Outcome ◽  
Artificial Insemination ◽  
Scoring System ◽  
Fixed Time ◽  
Beef Cows ◽  
Vaginal Ph ◽  
Pregnancy Status ◽  
Ph Range ◽  
System 1

Abstract The objective of this study was to evaluate the effect of vaginal pH on fertility of beef cows and heifers enrolled in a fixed-time artificial insemination (TAI) protocol. Year 1, 40 multiparous cows; and year 2, 48 multiparous cows and 41 heifers with no signs of vaginitis were enrolled. Vaginal flushes were collected for all females on D0, D7 and D10 and immediately analyzed for pH with a pH meter. As evidence of vaginitis, CIDR score was determined at CIDR removal (D7) following a 1 to 4 scoring system: 1=no secretion; 2=clear secretion; 3=purulent secretion; 4=purulent secretion and blood. Pregnancy status was determined by transrectal ultrasonography approximately 40 days after TAI. No animals had CIDR scores 1, whereas 23.7% of animals had a score 2, 69.6% a score 3, and 6.6% a score of 4. There was no effect of CIDR score on pregnancy outcome (P = 0.697). However, vaginal pH on D7, differed according to CIDR score (P = 0.045), where score 2 had greater pH (7.32±0.04) than score 4 (7.09±0.08), and score 3 were intermediate (7.25±0.02). No effect (P = 0.307) of CIDR score on vaginal pH on D10 was observed. There were no differences (P > 0.01) between vaginal pH of pregnant and open animals on D0 (7.06±0.05); D7 (7.26±0.03); and D10 (7.21±0.04). Nonetheless, on D10 females with vaginal pH 7.1 < pH ≤ 7.34 had greater (P = 0.005) PR (n=56; 66.1%) than cows with pH > 7.35 (n=33; 45.5%), and pH < 7.09 (n = 39; 33.3%). We conclude that vaginitis caused by the CIDR changes vaginal pH on D7, which is not carried on to D10. In addition, there is indication of an optimal vaginal pH range at the day of TAI for maximum PR to the protocol.

Influence of a controlled internal drug release after fixed-time artificial insemination on pregnancy rates and returns to estrus of nonpregnant cows1

2009 ◽  
Vol 87 (3) ◽  
pp. 914-921 ◽  
Author(s):  
J. E. Larson ◽  
K. N. Thielen ◽  
B. J. Funnell ◽  
J. S. Stevenson ◽  
D. J. Kesler ◽  
...  
Keyword(s):  
Drug Release ◽  
Artificial Insemination ◽  
Fixed Time ◽  
Pregnancy Rates

Induction of oestrus in ewes using a controlled internal drug release device and PMSG

1986 ◽  
Vol 106 (1) ◽  
pp. 201-203 ◽  
Author(s):  
W. M. C. Maxwell ◽  
D. R. Barnes
Keyword(s):  
Drug Release ◽  
Artificial Insemination ◽  
Day Treatment ◽  
Fixed Time ◽  
Oestrous Cycle ◽  
Release Device

A number of methods have been developed for synchronization of oestrus in sheep (reviewed by Maxwell, 1984), but the most successful have been based on the suppression of the oestrous cycle by treatment with a polyurethane progestagenimpregnated intravaginal sponge (Robinson, 1965). A precise synchronization of oestrus and ovulation for artificial insemination (A.I.) is obtained following a 12- to 14-day treatment with the intravaginal sponge and an injection of pregnant mares serum gonadotrophin (PMSG) at sponge removal (Robinson & Smith, 1967). This allows a single fixed time A.I. to be performed on all ewes without the need for detection of oestrus.

scholarly journals Effect of two prostaglandin F2α injections administered 24 hours apart on the pregnancy rate of Simmental cows subjected to the Ovsynch or Ovsynch + Controlled internal drug release (CIDR) protocols

2020 ◽  
Vol 76 (10) ◽  
pp. 6451-2020
Author(s):  
MUSHAP KURU ◽  
CIHAN KACAR ◽  
HASAN ORAL ◽  
SEMRA KAYA ◽  
NEBI CETIN ◽  
...  
Keyword(s):  
Drug Release ◽  
Pregnancy Rate ◽  
Artificial Insemination ◽  
Pregnancy Loss ◽  
Prostaglandin F2α ◽  
Fixed Time ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The aim of the present study was to determine the effects of one or two doses of prostaglandin F2α (PGF) on the pregnancy rate (PR) in Simmental cows subjected to the Ovsynch or Ovsynch + Controlled internal drug release (CIDR) protocols. On d 0, 100 µg gonadorelin diacetate tetrahydrate (GnRH) was injected into cows in group 1 (n = 50) and group 2 (n = 40) and CIDR was intravaginally inserted. On d 7, 25 mg dinoprost tromethamine (PGF2α, PGF) was administered, and GnRH was injected 56 h later. Fixed-time artificial insemination (TAI) was performed 16 h after GnRH injection. In group 3 (n = 62) and group 4 (n = 63), PGF was administered 7 d following GnRH treatment, and GnRH was injected 56 h later. TAI was performed 16 h after GnRH injection. In groups 2 and 4, a second dose of PGF was injected 24 h after the first dose. Pregnancy was determined by transrectal ultrasonography on d 30 and 60 post-TAI. The pregnancy rate (PR) on d 30 post-TAI was significantly different among the groups: 46%, 55%, 29%, and 36.5%, in groups 1, 2, 3, and 4, respectively (P = 0.048). In addition, the PR was 36.3% and 43.7% in the single PGF and double PGF injection groups, respectively. There was no statistical difference in the PR on d 60 post-TAI (P > 0.05). Pregnancy loss was between 4.34% and 11.11% (P > 0.05). The highest PR in the primiparous cows was observed in group 3 (57.7%). The PR was not significantly different among multiparous cows (P > 0.05). In conclusion, two injections of PGF administered 24 h apart in Simmental cows may increase the PR in the Ovsynch or Ovsynch + CIDR protocols.

233 Estrus Response and Pregnancy Rates of Beef Replacement Heifers Enrolled in Two Fixed-time Artificial Insemination Protocols, with or Without Pre-synchronization

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 125-126
Author(s):  
Vitor R G Rodrigues Gomes Mercadante ◽  
G Cliff C Lamb ◽  
Nicky Oosthuizen ◽  
Nicholas W Wege Dias ◽  
Stefania Pancini ◽  
...  
Keyword(s):  
Body Weight ◽  
Pregnancy Rate ◽  
Artificial Insemination ◽  
Prolonged Exposure ◽  
Prostaglandin F2α ◽  
Fixed Time ◽  
Transrectal Ultrasonography ◽  
Beef Heifers ◽  
Estrus Response ◽  
Exogenous Progesterone

Abstract Pre-synchronization strategies with prolonged exposure to exogenous progesterone have the potential to alter estrus expression and improve fertility in replacement beef heifers. The objective of this study was to evaluate the estrus response and pregnancy rate of beef heifers enrolled in two fixed-time artificial insemination (TAI) protocols. A total of 306 heifers (14 ± 2 months of age; 372 ± 24 kg body weight [BW]) at three locations were enrolled in the study. Within location, heifers were stratified by age and BW and randomly assigned to one of two treatments: 1) PG-CIDR54 (n = 152), heifers were administered prostaglandin F2α (PGF; 25 mg) and a controlled internal drug releasing (CIDR) insert (Day -14), an injection of GnRH [100 μg (Day -7)], PGF injection and CIDR removal (Day 0), and a second injection of GnRH concurrently with TAI 54 ± 2 h later (Day 2); 2) 7-day CO-Synch+CIDR (CTRL; n = 154), heifers were administered GnRH (100 μg) and a CIDR insert (Day -7), PGF (25 mg) injection and CIDR removal (Day 0), and a second injection of GnRH concurrently with TAI 54 ± 2 h later (Day 2). All heifers received an estrus alert patch on Day 0 and were evaluated for patch activation at TAI on Day 2. Pregnancy was diagnosed by transrectal ultrasonography between 35 and 55 days after TAI. The percentage of heifers exhibiting estrus between Day 0 and 2 was greater (P < 0.01) in PG-CIDR54 compared with CTRL (77.0 and 39.6%, respectively). In addition, pregnancy rate to TAI tended (P = 0.08) to be greater for PG-CIDR54 compared with CTRL (48.0 and 38.3%, respectively). We conclude that beef heifers enrolled in the PG-CIDR54 protocol had increased estrus expression and tended to have greater pregnancy rate when compared with heifers enrolled in the 7-day CO-Synch+CIDR protocol.

Effect of recombinant bovine somatotropin on pregnancy rates of Nellore cows resynchronized with the use of new DIB and third use, and inseminated at fixed-time

2015 ◽  
Vol 4 (1) ◽  
pp. 356-362
Author(s):  
Josemara Silva Santos ◽  
Tania Cavalcante ◽  
Francisca Elda Ferreira Dias ◽  
Domenica Palomaris Mariano de Souza ◽  
Alencariano J.S. Falcão ◽  
...  
Keyword(s):  
Artificial Insemination ◽  
Linear Models ◽  
Plasma Concentrations ◽  
Fixed Time ◽  
Estradiol Benzoate ◽  
Pregnancy Rates ◽  
Recombinant Bovine Somatotropin ◽  
Equine Chorionic Gonadotropin ◽  
Rectal Palpation ◽  
Intravaginal Device

The objective of the experiment was to evaluate the effects of recombinant bovine somatropin (rbST), and the reuse of the progesterone (P4) releasing devices in resynchronization, on the pregnancy rates of Nellore cows submitted to fixed-time artificial insemination. A group of 123 multiparae Nellore cows, was submitted to a resynchronization protocol: on day 0 a Bovine Intravaginal Device (DIB® ) with 1,0g of P4 was implanted, associated with intramuscular administration of 2,0mg of estradiol benzoate (IM); on day 8 DIB was removed; and 1,0mg of estradiol cypionate, 0,15mg of prostaglandin F2? and 300 UI of equine chorionic gonadotropin were administered; on day 10, fixed-time artificial insemination was conducted (FTAI). The cows were randomized into G1 (n=12) – without rbST / with used Bovine Intravaginal Device, G2 (n=50) – without rbST / with new DIB, G3 (n=11) - with rbST / with used DIB and G4 (n=50) – with rbST/ with new DIB. rbST was introduced on the eighth day of the protocol. Sixty days after TAI, pregnancy diagnoses were conducted, via rectal palpation. Blood samples were taken on day 0, 8 and 10 of the protocol, in order to assess P4 plasma concentrations. Pregnancy rates were statistically evaluated through Generalized Linear Models Theory and their significance was tested with Analysis of Deviance. Pregnancy rates were 58%, 40%, 81% and 48% for G1, G2, G3 and G4, respectively, with significant statistical difference for G3. Plasma concentrations of P4 were not statistically different among groups, or collections. In view of the results obtained, we concluded that the administration of rbST in association with P4 DIB, used for the third time, improves pregnancy rates. Estrus resynchronization and re-insemination positively impacted pregnancy rates.

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