Induction of oestrus in ewes using a controlled internal drug release device and PMSG

1986 ◽  
Vol 106 (1) ◽  
pp. 201-203 ◽  
Author(s):  
W. M. C. Maxwell ◽  
D. R. Barnes
Keyword(s):  
Drug Release ◽  
Artificial Insemination ◽  
Day Treatment ◽  
Fixed Time ◽  
Oestrous Cycle ◽  
Release Device

A number of methods have been developed for synchronization of oestrus in sheep (reviewed by Maxwell, 1984), but the most successful have been based on the suppression of the oestrous cycle by treatment with a polyurethane progestagenimpregnated intravaginal sponge (Robinson, 1965). A precise synchronization of oestrus and ovulation for artificial insemination (A.I.) is obtained following a 12- to 14-day treatment with the intravaginal sponge and an injection of pregnant mares serum gonadotrophin (PMSG) at sponge removal (Robinson & Smith, 1967). This allows a single fixed time A.I. to be performed on all ewes without the need for detection of oestrus.

Influence of a controlled internal drug release after fixed-time artificial insemination on pregnancy rates and returns to estrus of nonpregnant cows1

2009 ◽  
Vol 87 (3) ◽  
pp. 914-921 ◽  
Author(s):  
J. E. Larson ◽  
K. N. Thielen ◽  
B. J. Funnell ◽  
J. S. Stevenson ◽  
D. J. Kesler ◽  
...  
Keyword(s):  
Drug Release ◽  
Artificial Insemination ◽  
Fixed Time ◽  
Pregnancy Rates

Effect of type of intravaginal progestagen on the outcome of fixed-time artificial insemination

1981 ◽  
Vol 96 (1) ◽  
pp. 243-245 ◽  
Author(s):  
P. A. Smith ◽  
M. P. Boland ◽  
I. Gordon
Keyword(s):  
Artificial Insemination ◽  
Present Experiment ◽  
Fixed Time ◽  
Field Trials ◽  
Oestrous Cycle ◽  
Conception Rates ◽  
Natural Service ◽  
Dose Levels ◽  
Pregnant Mare Serum Gonadotrophin

It is now possible to synchronize the cycle of ewes at all times of the year (Gordon, 1975). Conception rates approaching those obtained following natural service have been reported following double (Colas & Brice, 1970; Colas et al. 1973; Barlow, Pryce-Jones & Reed, 1974; Gordon, 1975) or single (Smith, Boland & Gordon, 1978) set-time inseminations. In France, synchronization of ewes' oestrous cycle is based on the use of a Cronolone pessary (Colas, 1975), while field trials conducted in Britain have used the 60 mg Medroxy progesterone acetate (MAP) sponge (Barlow et al. 1974). Robinson et al. (1967) in an evaluation of different progestagen treatments found MAP to be less predictable than Cronolone. The purpose of the present experiment therefore was to evaluate the use of a 30 mg Cronolone or a 60 mg MAP intravaginal treatment when used in conjunction with fixed-time inseminations. In addition, two dose levels of pregnant mare serum gonadotrophin (PMSG) were compared.

scholarly journals Controlled Internal Drug Release (CIDR) Based Hormonal Protocols Effect upon Estrus Response and Pregnancy Outcome in Anestrous Cows

2019 ◽  
Vol 36 ◽  
pp. 46-52
Author(s):  
A. K. Sah ◽  
Y. R Pandeya ◽  
L. R Pathak ◽  
G. Gautam
Keyword(s):  
Drug Release ◽  
Pregnancy Outcome ◽  
Artificial Insemination ◽  
Research Programme ◽  
Fixed Time ◽  
Research Findings ◽  
Expression Rate ◽  
Estrus Response ◽  
Jersey Cows ◽  
Poor Pregnancy Outcome

 Controlled internal drug release (CIDR) based hormonal protocols CoSynch + CIDR, OvSynch + CIDR and CIDR + PGF2α were applied to 25 crossbred anestrous Holstein and Jersey cows to improve the fertility at the farm of National Cattle Research Programme, Rampur, Chitwan. All three protocols were found equally effective (P>0.05) with 100% estrus expression rate, out of which, 80% (8/10), 85.7% (6/7) and 75% (6/8) had estrus expression with well cervix open at fixed time artificial insemination in CoSynch + CIDR, OvSynch + CIDR and CIDR + PGF2α protocols respectively and rest had estrus expression with partial cervix open. Statistically non-significant (P>0.05) pregnancy outcome that is 14.3 % (1/7) in CIDR+PGF2α group and 12.5 % (1/8) in OvSynch group while none in CoSynch + CIDR group were pregnant following fixed time artificial insemination. Poor pregnancy outcome of the anestrous cows in all protocols might not only have hormonal problem but also could have various other reasons which was beyond the objective of this research findings. Hence, study concludes anestrous cows respond well to the CIDR based hormonal protocols to revive the estrus.  

24 The Effects of Vaginal pH on Fertility of Beef Cows and Heifers Enrolled in the 7-d Co-synch + Controlled Internal Drug Release (CIDR) Protocol

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 9-10
Author(s):  
Nicholas W Wege Dias ◽  
Stefania Pancini ◽  
Hannah Haines ◽  
Vitor R G Rodrigues Gomes Mercadante
Keyword(s):  
Drug Release ◽  
Pregnancy Outcome ◽  
Artificial Insemination ◽  
Scoring System ◽  
Fixed Time ◽  
Beef Cows ◽  
Vaginal Ph ◽  
Pregnancy Status ◽  
Ph Range ◽  
System 1

Abstract The objective of this study was to evaluate the effect of vaginal pH on fertility of beef cows and heifers enrolled in a fixed-time artificial insemination (TAI) protocol. Year 1, 40 multiparous cows; and year 2, 48 multiparous cows and 41 heifers with no signs of vaginitis were enrolled. Vaginal flushes were collected for all females on D0, D7 and D10 and immediately analyzed for pH with a pH meter. As evidence of vaginitis, CIDR score was determined at CIDR removal (D7) following a 1 to 4 scoring system: 1=no secretion; 2=clear secretion; 3=purulent secretion; 4=purulent secretion and blood. Pregnancy status was determined by transrectal ultrasonography approximately 40 days after TAI. No animals had CIDR scores 1, whereas 23.7% of animals had a score 2, 69.6% a score 3, and 6.6% a score of 4. There was no effect of CIDR score on pregnancy outcome (P = 0.697). However, vaginal pH on D7, differed according to CIDR score (P = 0.045), where score 2 had greater pH (7.32±0.04) than score 4 (7.09±0.08), and score 3 were intermediate (7.25±0.02). No effect (P = 0.307) of CIDR score on vaginal pH on D10 was observed. There were no differences (P > 0.01) between vaginal pH of pregnant and open animals on D0 (7.06±0.05); D7 (7.26±0.03); and D10 (7.21±0.04). Nonetheless, on D10 females with vaginal pH 7.1 < pH ≤ 7.34 had greater (P = 0.005) PR (n=56; 66.1%) than cows with pH > 7.35 (n=33; 45.5%), and pH < 7.09 (n = 39; 33.3%). We conclude that vaginitis caused by the CIDR changes vaginal pH on D7, which is not carried on to D10. In addition, there is indication of an optimal vaginal pH range at the day of TAI for maximum PR to the protocol.

scholarly journals Effect of two prostaglandin F2α injections administered 24 hours apart on the pregnancy rate of Simmental cows subjected to the Ovsynch or Ovsynch + Controlled internal drug release (CIDR) protocols

2020 ◽  
Vol 76 (10) ◽  
pp. 6451-2020
Author(s):  
MUSHAP KURU ◽  
CIHAN KACAR ◽  
HASAN ORAL ◽  
SEMRA KAYA ◽  
NEBI CETIN ◽  
...  
Keyword(s):  
Drug Release ◽  
Pregnancy Rate ◽  
Artificial Insemination ◽  
Pregnancy Loss ◽  
Prostaglandin F2α ◽  
Fixed Time ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The aim of the present study was to determine the effects of one or two doses of prostaglandin F2α (PGF) on the pregnancy rate (PR) in Simmental cows subjected to the Ovsynch or Ovsynch + Controlled internal drug release (CIDR) protocols. On d 0, 100 µg gonadorelin diacetate tetrahydrate (GnRH) was injected into cows in group 1 (n = 50) and group 2 (n = 40) and CIDR was intravaginally inserted. On d 7, 25 mg dinoprost tromethamine (PGF2α, PGF) was administered, and GnRH was injected 56 h later. Fixed-time artificial insemination (TAI) was performed 16 h after GnRH injection. In group 3 (n = 62) and group 4 (n = 63), PGF was administered 7 d following GnRH treatment, and GnRH was injected 56 h later. TAI was performed 16 h after GnRH injection. In groups 2 and 4, a second dose of PGF was injected 24 h after the first dose. Pregnancy was determined by transrectal ultrasonography on d 30 and 60 post-TAI. The pregnancy rate (PR) on d 30 post-TAI was significantly different among the groups: 46%, 55%, 29%, and 36.5%, in groups 1, 2, 3, and 4, respectively (P = 0.048). In addition, the PR was 36.3% and 43.7% in the single PGF and double PGF injection groups, respectively. There was no statistical difference in the PR on d 60 post-TAI (P > 0.05). Pregnancy loss was between 4.34% and 11.11% (P > 0.05). The highest PR in the primiparous cows was observed in group 3 (57.7%). The PR was not significantly different among multiparous cows (P > 0.05). In conclusion, two injections of PGF administered 24 h apart in Simmental cows may increase the PR in the Ovsynch or Ovsynch + CIDR protocols.

Effect of dose of Gronolone in intravaginal sponges on lambing outcome to fixed-time artificial insemination

1981 ◽  
Vol 96 (1) ◽  
pp. 253-254 ◽  
Author(s):  
P. A. Smith ◽  
M. P. Boland ◽  
I. Gordon
Keyword(s):  
Artificial Insemination ◽  
Ovarian Stimulation ◽  
Present Experiment ◽  
Intramuscular Injection ◽  
Relative Effectiveness ◽  
Fixed Time ◽  
Oestrous Cycle ◽  
High Concentration ◽  
High Degree ◽  
Pregnant Mare Serum Gonadotrophin

Research has shown that it is now possible to control the oestrous cycle of ewes with a high degree of precision (Robinson et al. 1967; Gordon, 1975; Boland, Kelleher & Gordon, 1978). There is general agreement that a high concentration of progestagen, followed by rapid withdrawal and adequate ovarian stimulation is necessary for acceptable fertility (Robinson et al. 1967; Gordon, 1975; Colas, 1975). Application of artificial insemination in France has involved the use of a 40–45 mg Cronolone sponge (Cognie, Mariana & Thimonier, 1970; Colas et al. 1973) while controlled breeding in sheep in Ireland has been used in conjunction with a 30 mg Cronolone pessary (Gordon, 1975; Smith, Boland & Gordon, 1978, 1981). The present experiment was designed to compare the relative effectiveness of two doses of Cronolone (30 or 45 mg) when administered in conjunction with two quantities(375 or 750 i.u.) of pregnant mare serum gonadotrophin (PMSG), given by intramuscular injection.

scholarly journals Nutzung einer terminorientierten Besamung beim Rind auf der Grundlage einer Prostaglandin – GnRH-Behandlung

2004 ◽  
Vol 47 (1) ◽  
pp. 27-36
Author(s):  
F. Becker ◽  
E. Kanitz ◽  
F. Schneider ◽  
G. Nürnberg ◽  
W. Kanitz
Keyword(s):  
Artificial Insemination ◽  
Fixed Time ◽  
Pregnancy Rates ◽  
Oestrous Cycle ◽  
Lh Surge ◽  
Dairy Heifers ◽  
65 H ◽  
The Mean ◽  
Timed Artificial Insemination ◽  
Predetermined Time

Abstract. Title of the paper: Practical application of timed artificial insemination in cattle using a GnRH and Prostaglandin treatment Three experiments were conducted to establish a regime of oestrous synchronization and artificial insemination at a predetermined time in dairy cattle. In experiment 1, dairy heifers (n = 43) were synchronized by administering PGF2α on day 5, 8, 11 or 14 and the LH surge was recorded. Release of the LH surge ranged from 57.0 ± 8.6 h to 76.3 ± 10.0 h depending upon the day of induced luteolysis. The release of LH was followed by ovulations. The day of PGF2α administration did not affect the interval from LH peak to ovulation. In experiment 2, heifers (n = 30) were synchronized on days 8, 11 or 14 of the oestrous cycle. Animals received an injection of GnRH 65 h after induction of luteolysis. Uniform intervals from PGF2α application to LH surge were observed in animals given PGF2α on day 11 and 14. Variation for this parameter decreased also in the group of animals where luteolysis was induced on day 8. There were no significant differences due to treatment in the mean interval from LH-peak to ovulation. In experiment 3, fixed time insemination was tested on the basis of data from Experiments 1 and 2. Synchronized heifers and high yielding cows received GnRH 65 hours after PGF2α administererd between d 8 and 14 of the oestrous cycle. Artificial insemination was carried out 13 h after GnRH application. Pregnancy rates show, that fixed time artificial insemination, independent of the recorded onset of estrus can result in high pregnancy rates. Pregnancy rates in animals at different locations were higher after induction of ovulation and timed artificial insemination (79.0, 76.0 and 47.1, 53.3 %) than in control groups with insemination after detected estrus (69.8, 63.2 and 38.6, 45.0 %).

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