The use of antimicrobial substances in food animals: The big picture

2011 ◽  
Author(s):  
Thomas Blaha
Keyword(s):  
Antimicrobial Substances ◽  
Big Picture ◽  
Food Animals

Antibiotika in der Veterinärmedizin: Einsatz und Reduktion

2018 ◽  
Vol 143 (09) ◽  
pp. 651-657
Author(s):  
Thomas Blaha
Keyword(s):  
Critical Analysis ◽  
Human Medicine ◽  
Short History ◽  
Farm Level ◽  
Antimicrobial Substances ◽  
History Of ◽  
Food Animals ◽  
Remarkable Reduction

AbstractAfter a short history of the development of antimicrobial substances and the initially underestimated resistance problem, the paper describes the method of monitoring the use of antibiotics in food animals at farm level. The resulting benchmarking led to a remarkable reduction of the amount of antibiotics used in animals. However, it is also explained that, apart from reducing the use of antibiotics, the rules for “prudent use” of antibiotics have to be complied with. Concluding, a critical analysis of the effectiveness of the current interpretation of the “critically important antimicrobials for human medicine is discussed.

Portraits But No Big Picture

1995 ◽  
Vol 40 (9) ◽  
pp. 870-871
Author(s):  
Valerian J. Derlega
Keyword(s):  
Big Picture

Looking Upstream and into the Watershed for the Big Picture of Stream Health

2009 ◽  
Author(s):  
Christina Y. S. Siu ◽  
Shirley E. Clark ◽  
Ruth A. Sitler ◽  
Katherine H. Baker
Keyword(s):  
Stream Health ◽  
Big Picture

Epic and Novel

2013 ◽  
Vol 68 (3) ◽  
pp. 396-422 ◽  
Author(s):  
Natasha Moore
Keyword(s):  
Nineteenth Century ◽  
Everyday Life ◽  
Economic Life ◽  
Modern World ◽  
The Novel ◽  
Aurora Leigh ◽  
Big Picture

This essay explores a peculiarly Victorian solution to what was perceived, in the middle of the nineteenth century, as a peculiarly Victorian problem: the fragmentation and miscellaneousness of the modern world. Seeking to apprehend the multiplicity and chaos of contemporary social, intellectual, political, and economic life, and to furnish it with a coherence that was threatened by encroaching religious uncertainty, Victorian poets turned to the resources of genre as a means of accommodating the heterogeneity of the age. In particular, by devising ways of fusing the conventions of the traditional epic with those of the newly ascendant novel, poets hoped to appropriate for the novelistic complexity of modern, everyday life the dignifying and totalizing tendencies of the epic. The essay reevaluates the generic hybridity of Elizabeth Barrett Browning’s Aurora Leigh (1856) as an attempt to unite two distinct kinds of length—the microscopic, cumulative detail of the novel and the big-picture sweep of the epic—in order to capture the miscellaneousness of the age and, at the same time, to restore order and meaning to the disjointed experience of modernity.

The Big Picture for Large-Screen Television Viewing

2012 ◽  
Vol 52 (4) ◽  
pp. 421-432 ◽  
Author(s):  
Michael D. McNiven ◽  
Dean Krugman ◽  
Spencer F. Tinkham
Keyword(s):  
Television Viewing ◽  
Large Screen ◽  
Big Picture

Antimicrobial Activity of Iron-Halide Complexes Against Gram-Positive and Gram-Negative Bacteria

2020 ◽  
Author(s):  
Nusrat Abedin ◽  
Abdullah Hamed A Alshehri ◽  
Ali M A Almughrbi ◽  
Olivia Moore ◽  
Sheikh Alyza ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Resistance ◽  
Extracellular Dna ◽  
Antibiofilm Activity ◽  
Gram Negative Bacteria ◽  
Bacterial Strains ◽  
Gram Positive ◽  
Gram Negative ◽  
Antimicrobial Substances ◽  
Mammalian Cell Lines

Antimicrobial resistance (AMR) has become one of the more serious threats to the global health. The emergence of bacteria resistant to antimicrobial substances decreases the potencies of current antibiotics. Consequently, there is an urgent and growing need for the developing of new classes of antibiotics. Three prepared novel iron complexes have a broad-spectrum antimicrobial activity with minimum bactericidal concentration (MBC) values ranging from 3.5 to 10 mM and 3.5 to 40 mM against Gram-positive and Gram-negative bacteria with antimicrobial resistance phenotype, respectively. Time-kill studies and quantification of the extracellular DNA confirmed the bacteriolytic mode of action of the iron-halide compounds. Additionally, the novel complexes showed significant antibiofilm activity against the tested pathogenic bacterial strains at concentrations lower than the MBC. The cytotoxic effect of the complexes on different mammalian cell lines show sub-cytotoxic values at concentrations lower than the minimum bactericidal concentrations.

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