scholarly journals The issues of alcohol withdrawal syndrome: current state of the problem

2019 ◽  
Vol 23 (4) ◽  
pp. 745-748
Author(s):  
O. Havrylov

Annotation. Alcohol addiction is one of the three main health problems in the world, which directly or indirectly increases the mortality rate, wherein it poses the greatest threat to the developed countries of Europe and America. Identification of promising directions for resolving the issue of alcohol withdrawal syndrome with delirium is one of the levers to reduce the consequences of its harmful use. It was made an analysis of the electronic database of scientific publications Pubmed and the latest WHO data, the main approaches to the pathogenesis and intensive care of alcoholic delirium in Ukraine and abroad were highlighted and displayed, clinical and laboratory diagnostic aspects were distinguished. There is a certain vision of the pathogenesis of alcohol withdrawal syndrome as an imbalance in the GABA and glutamate-ergic systems in brain neurons. Diagnostic criteria have been developed and introduced into clinical practice to determine the severity of withdrawal status, as well as sedation-agitation scales, it is not completely determined the influence of electrolyte disturbances, namely magnesium deficiency on the severity of the condition, the effectiveness of sedation and mortality. The optimal way to increase the effectiveness of the treatment of alcoholic delirium, which would ensure an adequate level of sedation, has not yet been found all over the world, at the same time, without increasing the risk of complications in the form of an overdose of tranquilizers and hypnotics, both in case of their isolated and combined use. The possibility of using chelate compounds containing GABA in themselves, as well as organic magnesium salts, namely gluconic acid salts, is promising.

1958 ◽  
Vol 19 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Lincoln Godfrey ◽  
Martin D. Kissen ◽  
Thomas M. Downs

1997 ◽  
Vol 14 (2) ◽  
pp. 172-187
Author(s):  
Arif Sultan

Within a short span of time a number of economic blocs have emergedon the world horizon. In this race, all countriedeveloped, developingand underdeveloped-are included. Members of the North America FreeTrade Agreement (NAITA) and the European Economic Community(EEC) are primarily of the developed countries, while the EconomicCooperation Organization (ECO) and the Association of South EastAsian Nations (ASEAN) are of the developing and underdevelopedAsian countries.The developed countries are scrambling to create hegemonies throughthe General Agreement on Tariff and Trade (GATT). In these circumstances,economic cooperation among Muslim countries should be onthe top of their agenda.Muslim countries today constitute about one-third of the membershipof the United Nations. There are around 56 independentMuslim states with a population of around 800 million coveringabout 20 percent of the land area of the world. Stretchingbetween Atlantic and the Pacific Oceans, the Muslim Worldstraddles from North Africa to Indonesia, in two major Islamicblocs, they are concentrated in the heart of Africa to Indonesia,in two major blocs, they are concentrated in the heart of Africaand Asia and a smaller group in South and Southeast Asia.'GATT is a multilateral agreement on tariffs and trade establishing thecode of rules, regulations, and modalities regulating and operating internationaltrade. It also serves as a forum for discussions and negotiations ...


2010 ◽  
Vol 27 (4) ◽  
pp. 23-44
Author(s):  
Ruzita Mohd. Amin

The World Trade Organization (WTO), established on 1 January 1995 as a successor to the General Agreement on Tariffs and Trade (GATT), has played an important role in promoting global free trade. The implementation of its agreements, however, has not been smooth and easy. In fact this has been particularly difficult for developing countries, since they are expected to be on a level playing field with the developed countries. After more than a decade of existence, it is worth looking at the WTO’s impact on developing countries, particularly Muslim countries. This paper focuses mainly on the performance of merchandise trade of Muslim countries after they joined the WTO. I first analyze their participation in world merchandise trade and highlight their trade characteristics in general. This is then followed by a short discussion on the implications of WTO agreements on Muslim countries and some recommendations on how to face this challenge.


2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Tessa L. Steel ◽  
Shewit P. Giovanni ◽  
Sarah C. Katsandres ◽  
Shawn M. Cohen ◽  
Kevin B. Stephenson ◽  
...  

Abstract Background The Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar) is commonly used in hospitals to titrate medications for alcohol withdrawal syndrome (AWS), but may be difficult to apply to intensive care unit (ICU) patients who are too sick or otherwise unable to communicate. Objectives To evaluate the frequency of CIWA-Ar monitoring among ICU patients with AWS and variation in CIWA-Ar monitoring across patient demographic and clinical characteristics. Methods The study included all adults admitted to an ICU in 2017 after treatment for AWS in the Emergency Department of an academic hospital that standardly uses the CIWA-Ar to assess AWS severity and response to treatment. Demographic and clinical data, including Richmond Agitation-Sedation Scale (RASS) assessments (an alternative measure of agitation/sedation), were obtained via chart review. Associations between patient characteristics and CIWA-Ar monitoring were tested using logistic regression. Results After treatment for AWS, only 56% (n = 54/97) of ICU patients were evaluated using the CIWA-Ar; 94% of patients had a documented RASS assessment (n = 91/97). Patients were significantly less likely to receive CIWA-Ar monitoring if they were intubated or identified as Black. Conclusions CIWA-Ar monitoring was used inconsistently in ICU patients with AWS and completed less often in those who were intubated or identified as Black. These hypothesis-generating findings raise questions about the utility of the CIWA-Ar in ICU settings. Future studies should assess alternative measures for titrating AWS medications in the ICU that do not require verbal responses from patients and further explore the association of race with AWS monitoring.


2002 ◽  
Vol 24 (3) ◽  
pp. 446-454 ◽  
Author(s):  
Sven Ulrich ◽  
Peter Danos ◽  
Bruno Baumann ◽  
Dörthe Müller ◽  
Dörthe Lehmann ◽  
...  

1990 ◽  
Vol 73 (3A) ◽  
pp. NA-NA
Author(s):  
Thomas Hell ◽  
Dirk Martens ◽  
Klaus Eyrlch

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