scholarly journals Severe Oro-laryngeal Thrush Following Excessive Use of Steroid Inhaler

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Marina MB ◽  
Ramli R ◽  
Primuharsa Putra SHA
Keyword(s):  
Side Effects ◽  
Muscle Power ◽  
Inhaled Corticosteroids ◽  
Fungal Infections ◽  
Complete Recovery ◽  
Asthmatic Patients ◽  
Inhaled Steroids ◽  
Laryngeal Mucosa ◽  
Loss Of Appetite ◽  
Local Side

Introduction: Inhaled steroids such as fluticasone propionate and beclomethasone dipropionate play an important role in the treatment of bronchial asthma. Its usage facilitates disease control in asthmatic patients, resulting in improved quality of life. Because of its benefit, the inhaled steroid is used extensively, at higher doses and for longer duration. However, the localized effects of inhaled corticosteroids on oral/laryngeal mucosa, such as fungal infections can be problematic. Case Report: We report a case of oropharyngeal and laryngeal candidiasis following a long period and high doses of inhaled steroid in a 42-year-old male. He presented with a complaint of increasing tiredness, phlegm, intermittent wheezing and hoarseness for 2-3 months. There was no weight loss or loss of appetite. He has been using inhaled steroids and long acting bronchodilators in increasing doses for his claimed ‘wheezing’ despite the negative history of asthma. The inhaled steroids were fluticasone dipropionate at doses of 500-100 mcg daily for 2-3 months. Results: Examination revealed widespread oral thrush involving the oral cavity, oropharynx and larynx. There was no cushingoid habitus. His muscle power was of 5/5 bilaterally and his lungs were clear. Lung function and chest film were also normal. The steroid was stopped immediately and flucanozole and nystatin syrup were prescribed. The patient made an uneventful and complete recovery. Conclusion: We conclude that patients on inhaled corticosteroids should be monitored for local side effects. Physicians should be aware not only of the systemic but also of the local side effects of inhaled corticosteroids. Patients may increase doses without the knowledge of their physicians and subsequently suffer the adverse effects either local or systemic.

The Local Side Effects of Inhaled Corticosteroids

CHEST Journal ◽  
2004 ◽  
Vol 126 (1) ◽  
pp. 213-219 ◽  
Author(s):  
Nicholas J. Roland ◽  
Rajiv K. Bhalla ◽  
John Earis
Keyword(s):  
Side Effects ◽  
Inhaled Corticosteroids ◽  
Local Side

scholarly journals Voice changes associated with inhaled steroids 1n obstructive lung disease patients

2020 ◽  
Vol 12 (1) ◽  
pp. 1-7
Author(s):  
Baraka M ◽  
Hossam ElDessouky ◽  
Ahmed Amer Khamees ◽  
Ayman Ali Abd ElFattah ◽  
Eman Ezzat ◽  
...  
Keyword(s):  
Side Effects ◽  
Lung Disease ◽  
Bronchial Asthma ◽  
Obstructive Lung Disease ◽  
Inhaled Corticosteroids ◽  
Group I ◽  
Voice Changes ◽  
Significant Difference ◽  
Local Side ◽  
Laryngeal Examination

Background/Aims: The widespread use of inhaled corticosteroids (ICS) for the treatment of obstructive lung disease may be associated with both systemic and local side effects. These local side effects; including voice problems, oropharyngeal candidiasis, throat clearing, sense of fullness, pharyngitis, and cough, are generally viewed as minor complications of therapy in what is called steroid inhaler laryngitis (SIL). Few studies have been performed to specifically evaluate local side effects of ICS. However, they can be clinically significant, affect patient's quality of life, hinder compliance with therapy, and mask symptoms of more serious disease. The aim of this study is to examine the effect of ICS on the larynx and subsequent voice changes, and highlighting if these voice problems related to the type of inhaled corticosteroids in order to determine the importance of regular laryngeal examination in those patients. Methods: 40patients with bronchial asthma and 40 patients with COPD admitted to Chest department in Menoufia and Zagazig University Hospitals during the period from March 2017 to March 2019 were included in the study. They were divided according to the type of cortisone used into four groups; group (I): beclomethasone dipropionate (BDP) users, group (II): budesonide (BUD) users, group (III): Ciclesonide users and group (IV): fluticasone propionate (FP) users. They were evaluated as regards videolaryngoscopic examination and acoustic analysis Results: The age of the patients with bronchial asthma ranged from 29 to 42years and the age of the patients with COPD ranged from 31 to 43years. There was a statistically significant difference among the four groups of cortisone inhalation regarding laryngoscopic findings; as presence of congestion (diffuse and local), mucus spills on VF and glottis gap were all higher in frequency among the group of patients used fluticasone FP, while least signs found among ciclesonide users. Also, average pitch, Jitter, H/N ratio and MPT were more worsen in fluticasone group when compared with Ciclesonide group. Conclusion: obstructive lung disease patients may suffer from voice problems related to the type of inhaled corticosteroids that could be fade when therapy is stopped. So, regular laryngeal examination in those patients is important.

Local side-effects during 4-year treatment with inhaled corticosteroids - a com between pressurized metered-dose in and Turbuhaler®

Allergy ◽  
1994 ◽  
Vol 49 (10) ◽  
pp. 888-890 ◽  
Author(s):  
O. Selroos ◽  
R. Backman ◽  
K.-O. Forsén ◽  
A.-B. Löfroos ◽  
M. Niemistö ◽  
...  
Keyword(s):  
Side Effects ◽  
Inhaled Corticosteroids ◽  
Metered Dose ◽  
Local Side

scholarly journals Patterns and Determinants of Compliance with Inhaled Steroids in Adults with Asthma

2005 ◽  
Vol 12 (4) ◽  
pp. 211-217 ◽  
Author(s):  
Yves Lacasse ◽  
Hélène Archibald ◽  
Pierre Ernst ◽  
Louis-Philippe Boulet
Keyword(s):  
Fluticasone Propionate ◽  
Inhaled Corticosteroids ◽  
Electronic Devices ◽  
Persistent Asthma ◽  
Point Of View ◽  
Review Of The Literature ◽  
Asthmatic Patients ◽  
Inhaled Steroids ◽  
Maintenance Medication ◽  
Daily Dose

BACKGROUND: Patient compliance with inhaled corticosteroids (ICS) in asthma is considered to be suboptimal.OBJECTIVES: To describe the patterns of compliance with ICS and identify factors determining the compliance to ICS in adults with asthma.METHODS: Based on a review of the literature and interviews with asthmatic patients who require the regular use of ICS, potential determinants of compliance to ICS were identified. Questionnaires related to these determinants were then administered to a cohort of patients from three subspecialty clinics, including two from university-affiliated centres. Patients with mild-to-moderate asthma who were 15 years of age and older and required (from the physician's point of view) ICS as maintenance medication because of persistent asthma were included in the study. Patients were followed for a period of 12 weeks. Compliance was measured using electronic devices.RESULTS: Data from 124 patients (51 men; mean age 47±15 years; mean prescribed daily dose of ICS [fluticasone propionate] 643±385 µg) were analyzed. On average, the patients took 72±24% of their prescription. Four patterns of compliance were observed and are described: 1A -- regular compliance (n=29); 1B -- irregular compliance (n=37); 2A -- regular noncompliance (n=24); and 2B -- irregular noncompliance (n=34). Among the potential predictors of noncompliance, age was the only significant predictor (compliance increased with increasing age). There was no difference in asthma control between compliant and noncompliant patients.CONCLUSION: Compliance to ICS in patients with asthma is often suboptimal and difficult to predict. The observations suggest that some asthmatics may be overtreated with ICS.

Local side-effects of inhaled corticosteroids in asthmatic children: influence of drug, dose, age, and device

Allergy ◽  
2001 ◽  
Vol 56 (10) ◽  
pp. 944-948 ◽  
Author(s):  
J. C. Dubus ◽  
C. Marguet ◽  
A. Deschildre ◽  
L. Mely ◽  
P. Le Roux ◽  
...  
Keyword(s):  
Side Effects ◽  
Inhaled Corticosteroids ◽  
Drug Dose ◽  
Asthmatic Children ◽  
Local Side

Local Treatment of Recent Arterial Thromboembolic Occlusions with Brinase

1975 ◽  
Vol 34 (02) ◽  
pp. 498-503 ◽  
Author(s):  
D Nyman ◽  
M. A da Silva ◽  
L. K Widmer ◽  
F Duckert
Keyword(s):  
Side Effects ◽  
Local Treatment ◽  
Before And After ◽  
Local Side

SummaryBrinase was administered intra-arterially in 16 patients with thrombotic or embolic arterial occlusions. Angiography could be performed before and after treatment in 13 patients. Thrombolysis was obtained in 3 of 9 patients with thrombotic and in 3 of 4 patients with embolic occlusions. In 3 patients severe local side effects occurred.

Sign in / Sign up

Export Citation Format

Share Document