scholarly journals Response Evaluation with Dynamic FDG PET/CT during the Primary Systemic Therapy of Breast Cancer - A Case Report

2021 ◽  
pp. 1-4
Author(s):  
Kornelia Kajary ◽  
Kornelia Kajary ◽  
Zsolt Lengyel ◽  
Anna-Maria Tokes ◽  
Janina Kulka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Fdg Pet ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Disease Free Survival ◽  
Dynamic Pet ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Fdg Pet Ct

18-fluorine-fluorodeoxyglucose (FDG) positron emission tomography (PET) and mainly combined with computed tomography (CT), abbreviated as FDG PET/CT is a useful and accurate tool for staging and restaging in locally advanced breast cancer. In daily practice static images are prepared during the PET/CT examinations. However, despite the success of static PET and PET/CT imaging, the role of precise quantification of FDG-uptake – measured by dynamic acquisition – is ambiguous in the staging and management of different malignancies. In this case report, we described our experience with staging, interim and restaging dynamic PET/CT examinations of a woman suffering from breast cancer. Based on the described case we concluded that dynamic PET/CT is suitable for accurate quantification of FDG-uptake in primary breast tumors. However, performing dynamic PET/CT examinations is time-consuming, therefore, it is important to define the group of patients where their use is with the most favourable benefit/risk ratio. Furthermore, using of interim PET/CT scan is recommended in cases with clinically controversial baseline tests. Based on literature in vivo biomarkers of the dynamic PET/CT are predictive of more favourable tumor response and longer disease-free survival, as confirmed by our own results.

Mediastinal schwannoma mimicking lymph node metastasis from locally advanced breast cancer in a 18 F-FDG PET/CT study

2016 ◽  
Vol 35 (4) ◽  
pp. 272-273 ◽  
Author(s):  
A. Martínez-Esteve ◽  
R.M. Álvarez-Pérez ◽  
V.M. Pachón-Garrudo ◽  
R. González-Mancha ◽  
I. Borrego-Dorado
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Advanced Breast Cancer ◽  
Fdg Pet ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Node Metastasis ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Utility of FDG-PET/CT in the Evaluation of the Response of Locally Advanced Breast Cancer to Neoadjuvant Chemotherapy

2014 ◽  
Vol 99 (4) ◽  
pp. 309-318 ◽  
Author(s):  
Kei Ogino ◽  
Masanobu Nakajima ◽  
Miyako Kakuta ◽  
Mitsuhiro Hayashi ◽  
Satoru Yamaguchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Fdg Pet ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Reduction Rate ◽  
Standardized Uptake Value ◽  
Pet Ct ◽  
Significant Difference ◽  
Fdg Pet Ct

Abstract Neoadjuvant chemotherapy (NAC) is effective in down-staging a primary tumor before surgery, and quick differentiation between responders to NAC and nonresponders is needed. We investigated the utility of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) and computed tomography (CT) in evaluating the therapeutic effectiveness of NAC. We investigated 25 patients who underwent NAC for stage II and III noninflammatory breast cancer. FDG-PET/CT was undertaken before and after NAC to determine the maximum standardized uptake value (SUVmax) reduction rate. Findings were compared with postoperative histopathologic evaluation of therapeutic response. It was not possible to accurately assess tumor response to NAC using CT. However, using the SUVmax reduction rate, we noted a significant difference (P = 0.0420) between patients who were responsive and nonresponsive to NAC. The sensitivity and specificity were as high as 83.3% and 78.9%, respectively. This study demonstrated that FDG-PET/CT can differentiate responders from nonresponders. This improves patient management by avoiding unnecessary chemotherapy.

scholarly journals FDG-PET-CT in the early response evaluation for primary systemic therapy of breast cancer

Open Medicine ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. 306-312
Author(s):  
Tímea Tőkés ◽  
László Torgyík ◽  
Janina Kulka ◽  
Katalin Borka ◽  
Attila Szász ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systemic Therapy ◽  
Fdg Pet ◽  
Imaging Modality ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Early Response ◽  
Primary Systemic Therapy ◽  
Pet Ct ◽  
Fdg Pet Ct

AbstractPrimary systemic therapy (PST) is a standard treatment for patients with locally advanced breast cancer. We report one of our patients to demonstrate the optimal use of FDG-PET-CT in the routine clinical workup during PST, especially when clinicians face contradictory clinical and pathological findings, and to show the advantages of this imaging modality in the decision-making process about the initial treatment choice. By reviewing the literature we would also like to confirm that FDG-PET-CT is highly sensitive in the measurement of the early therapeutic response and the prediction of the complete pathological remission, as early as after the first cycle of chemotherapy is administered.

Prediction of pathological response using 18F FDG PET/CT derived metabolic parameters in locally advanced breast cancer patients

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Salwa Abd El-Gaid ◽  
Marwa Nabil AbdelHafez ◽  
Ghada Mohamed ◽  
Mohamed Samy Saied Elazab ◽  
Mai Amr Elahmadawy
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Fdg Pet ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Pathological Response ◽  
Breast Cancer Patients ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Early and delayed prediction of axillary lymph node neoadjuvant response by 18F-FDG PET/CT in patients with locally advanced breast cancer

2014 ◽  
Vol 41 (7) ◽  
pp. 1309-1318 ◽  
Author(s):  
Ana María García Vicente ◽  
Ángel Soriano Castrejón ◽  
Alberto León Martín ◽  
Fernanda Relea Calatayud ◽  
María del Mar Muñoz Sánchez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Fdg Pet ◽  
Axillary Lymph Node ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Axillary Lymph ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
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