scholarly journals Dyskeratosis Congenita: Squamous Cell Carcinoma of the Buccal Mucosa on a Background of Lichen Planus – A Case Report During COVID-19 Pandemic

2021 ◽  
pp. 1-10
Author(s):  
Khaled Saleh Ben Salah ◽  
Khaled Saleh Ben Salah ◽  
Fatma M. Emaetig ◽  
Ebrahim H. El Mahjoubi ◽  
Abdalla O. Jebriel ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Premature Death ◽  
Dyskeratosis Congenita ◽  
Stated Condition ◽  
Simultaneous Existence ◽  
Lichenoid Reactions ◽  
Severe Disorder

Dyskeratosis Congenita is a severe disorder that involves several systems in the human body and is well-known for its transmission hereditarily through generations. The triad of a) reticular atrophy of the skin with pigmentation b) dystrophy of the nails c) leukoplakia of the oral mucosa characterises this uncommon disorder, which most commonly affects men. One of the key reasons for premature death in this disease is malignant transformation within areas of mucosal hyperkeratosis. In Dyskeratosis Congenita, the simultaneous existence of squamous cell carcinoma (SCC) with lichen planus and or lichenoid reactions in the mucosa of the oral cavity is a rare, stated condition. This report discusses a case of a Libyan male patient affected by Dyskeratosis Congenita that ended with buccal mucosal squamous cell carcinoma developed on a lichen planus background after thirty years of suffering at the age of 64.

Squamous cell carcinoma arising in oral lichen planus – case report and literature review

ORL ro ◽  
2020 ◽  
Vol 3 (48) ◽  
pp. 15
Author(s):  
Corina I. Cucu ◽  
Liliana Gabriela Popa ◽  
Călin Giurcăneanu ◽  
Vladimir S. Ibric Cioran ◽  
Cristina Beiu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Oral Lichen Planus ◽  
Oral Lichen

scholarly journals Hypertrophic Lichen Planus versus Well-Differentiated Squamous Cell Carcinoma: A Histological Challenge 

2017 ◽  
Vol 1 (2) ◽  
pp. 91
Author(s):  
Samuel P Haslam ◽  
Lindy S Ross ◽  
Alison C Lowe ◽  
Brent C Kelly
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Multiplex Pcr ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Correct Diagnosis ◽  
Pseudoepitheliomatous Hyperplasia ◽  
Lichen Simplex Chronicus ◽  
Well Differentiated

Differentiating hypertrophic lichen planus (LP) from well-differentiated squamous cell carcinoma (SCC) is a histological challenge given the numerous histopathologic similarities between SCC and pseudoepitheliomatous hyperplasia (PEH) arising in the setting of hypertrophic LP. Multiple reports have shown that SCC can arise from hypertrophic LP not infrequently, but that the LP-to-SCC sequence is poorly understood, and many cases defy diagnosis due to histologic similarities. However, there are several clinical clues and histopathologic details that have shown to have some value when trying to ascertain the correct diagnosis. To the contrary, immunohistochemical tests have shown little promise in differentiating hypertrophic LP from SCC. Although multiplex PCR has shown some potential in differentiating PEH from SCC, this has only been in the setting of patients diagnosed with prurigo and lichen simplex chronicus, but not necessarily in the case hypertrophic LP. 

Dyskeratosis congenita and squamous cell carcinoma of the mandibular alveolar ridge

2021 ◽  
Vol 14 (5) ◽  
pp. e242459
Author(s):  
Alfonso Manfuso ◽  
Antonio Maria Risitano ◽  
Chiara Copelli
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Skin Pigmentation ◽  
Dyskeratosis Congenita ◽  
Postoperative Recovery ◽  
Patient Comfort ◽  
Alveolar Ridge ◽  
Therapeutic Decisions ◽  
Disseminated Disease

Dyskeratosis congenita is a rare disease caused by telomerase dysfunction classically characterised by the triad: skin pigmentation, nail dystrophy and mucosal leukoplakia. Few cases are described in literature regarding patients with head and neck squamous cell carcinoma affected by dyskeratosis congenita, and the therapeutic decisions are not yet well defined. A review of the literature of the last 20 years (2001–2021) was performed, and it was analysed the case of a 38-year-old male patient affected by dyskeratosis congenita diagnosed with a squamous cell carcinoma of the inferior alveolar ridge, treated with surgery. The absence of complications and the good postoperative recovery of the patient comfort in saying that resection and reconstructive surgery can be safely performed. The occurrence of disseminated disease 6 months after the treatment warns about the extreme aggressiveness of the pathology, its often systemic nature and the necessity of a multidisciplinary approach as well as further studies.

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