scholarly journals Psychological and Neurocognitive Impact of Behcet’s Disease

2020 ◽  
pp. 1-8
Author(s):  
Caroline Fisher ◽  
Caroline Fisher
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Future Research ◽  
Long Term Memory ◽  
Routine Practice ◽  
Depression And Anxiety ◽  
Behcet's Disease ◽  
Visual Spatial

Behcet’s disease is a vasculitis, causing multisystem inflammation and resulting in oral and genital ulcers and eye and skin lesions. A proportion of suffers also have neurological involvement, termed neuro-Behcet’s disease. The purpose of this review was to investigate the psychological and neurocognitive sequelae associated with Behcet’s and neuro-Behcet’s disease and provide directions for future research. Depression and anxiety are the most researched psychological conditions in Behcet’s disease and appear to be the most consistently observed disorders across studies. Depression and anxiety severity is significantly higher relative to controls, and rates are similar across Behcet’s and neuro-Behcet’s cohorts. A systematic review would be helpful to fully determine the magnitude of these psychological disorders in Behcet’s disease and elucidate correlated clinical, regional and demographic factors. Further research is also needed into somatic and psychotic conditions as existing studies have yielded inconsistent results. Attenuations in neurocognitive functioning appear to be on a continuum. Reduced cognitive functioning is observed in Behcet’s disease relative to healthy controls; however, it is observed more frequently in neuro-Behcet’s disease, and in a broader range of neurocognitive domains (visual-spatial abilities, working memory, acquired knowledge, processing speed, long-term memory encoding and retrieval). Methodological limitations in existing studies, thus far, have not allowed for further synthesis of the data, such as through meta-analysis, and the field would benefit from several large-sample, multi-site studies using broad cognitive assessment batteries. Assessments of psychological functioning should be included as part of routine practice in clinics treating patients for Behcet’s disease. The potential for neurocognitive impairment should also be considered, particularly in those with neuro-Behcet’s. Appropriate referral pathways for psychiatric, psychological or neuropsychological intervention and treatment can then be offered, so that the psychological and neurocognitive needs in this patient cohort can be appropriately met.

scholarly journals Psychological and neurocognitive impact of Behcet’s disease

2020 ◽  
pp. 001-008
Author(s):  
Fisher Caroline A
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Skin Lesions ◽  
Neurological Involvement ◽  
Future Research ◽  
Behcet's Disease ◽  
Genital Ulcers

Background: Behcet’s disease is a vasculitis, causing multisystem inflammation and resulting in oral and genital ulcers and eye and skin lesions. A proportion of suffers also have neurological involvement, termed neuro-Behcet’s disease. The purpose of this review was to investigate the psychological and neurocognitive sequelae associated with Behcet’s and neuro-Behcet’s disease and provide directions for future research.

Increased complexin-1 and decreased miR-185 expression levels in Behçet’s disease with and without neurological involvement

2015 ◽  
Vol 37 (3) ◽  
pp. 411-416 ◽  
Author(s):  
Elif Uğurel ◽  
Elçin Şehitoğlu ◽  
Erdem Tüzün ◽  
Murat Kürtüncü ◽  
Arzu Çoban ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Behcet's Disease ◽  
Expression Levels

VEGF and mRNA VEGF expression in CSF from Behçet's disease with neurological involvement

2009 ◽  
Vol 213 (1-2) ◽  
pp. 148-153 ◽  
Author(s):  
Kamel Hamzaoui ◽  
Khaled Ayed ◽  
M'Hamed Hamza ◽  
Agnès Hamzaoui
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Vegf Expression ◽  
Behcet's Disease

scholarly journals Pattern recognition is a sequential process—accurate diagnosis and treatment 20 years after presentation

2019 ◽  
Vol 2019 (7) ◽  
Author(s):  
Dimos Merinopoulos ◽  
Janak Saada ◽  
Colin Jones ◽  
Chetan Mukhtyar
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
White Matter Lesions ◽  
Neurological Involvement ◽  
Neurological Manifestations ◽  
Visual Aura ◽  
Behcet's Disease ◽  
Ocular Manifestations ◽  
Retinal Haemorrhages

Abstract A 25-year-old woman presented with ophthalmic and neurological manifestations. Her ocular manifestations included bilateral uveitis, multifocal retinal phlebitis, vitreitis and multiple retinal haemorrhages. Her neurological manifestations included migrainous headaches with visual aura, transient sensory symptoms and posterior circulation Transient Ischemic Attack (TIA). Magnetic resonance imaging of the brain demonstrated lesions that involved the deep white matter lesions initially and progressed to also involve the juxta cortical white and deep grey matter and brain stem, but without further neurological manifestations. She was sequentially treated with intravenous and oral glucocorticoid, cyclophosphamide and mycophenolate mofetil, but she continued to suffer with persistent episodes of retinal haemorrhages. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), Susac syndrome and Behcet’s disease were considered in the differential diagnosis. Genetic workup and clinical picture were not suggestive of the former two. Further history of oro-genital ulceration in younger age emerged, which pointed strongly towards a diagnosis of Behcet’s disease with neurological involvement. She was treated with infliximab and methotrexate with complete resolution of her symptoms and withdrawal of corticosteroids for the first time in over two decades.

Clinical features and disease course of neurological involvement in Behcet's disease: HUVAC experience

2020 ◽  
Vol 38 ◽  
pp. 101512 ◽  
Author(s):  
Ertugrul Cagri Bolek ◽  
Alper Sari ◽  
Levent Kilic ◽  
Umut Kalyoncu ◽  
Asli Kurne ◽  
...  
Keyword(s):  
Clinical Features ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Disease Course ◽  
Behcet's Disease

scholarly journals The Clinical Features and Risk Factors of Parenchymal Neuro-Behcet’s Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Dong Yan ◽  
JinJing Liu ◽  
Yuehua Zhang ◽  
Wei Yuan ◽  
Yan Xu ◽  
...  
Keyword(s):  
Clinical Features ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Biological Agents ◽  
Neurological Involvement ◽  
Cervical Cord ◽  
Ocular Involvement ◽  
College Hospital ◽  
Behcet's Disease

To investigate the clinical features of parenchymal neuro-Behcet’s disease (p-NBD), we retrospectively reviewed the medical records of 1009 BD patients admitted to Peking Union Medical College Hospital from 2000 to 2016. Forty-two patients (25 males and 17 females) with p-NBD and eighty-four age- and sex-matched BD patients without neurological involvement who were served as controls were enrolled. Neurological onset was concomitant with the onset of BD in six cases (14.3%). Pyramidal signs (50.0%) and headache (33.3%) were the most common manifestations. On MRI, the lesions were mainly in the midline structures and hyperintense in the T2-weighted image. The most common lesion was the brainstem (54.8%). Spinal cord involvement was observed in five cases, four of which with cervical cord involvement. Multifocal lesions were observed in 13 patients. Ocular involvement was more prevalent in p-NBD (35.7%) (P=0.041, OR=2.36, 95% CI=1.03-5.44) compared with controls. All patients received corticosteroids and immunosuppressants, mainly cyclophosphamide (39/42). Six patients with severe/refractory condition received biological agents and achieved response measured by decreased Rankin score (P=0.002). With a median follow-up of 28 months, 22 patients (61.1%) achieved clinical improvements, while 10 (27.8%) relapsed and 4 died (mortality rate 11.1%). p-NBD is a rare yet disabling and life-threatening complication of BD. Ocular involvement is a risk factor for p-NBD. Promptly aggressive treatment is essential for improving prognosis, and biological agents might be a promising approach for severe/refractory p-NBD.

Cognitive impairment in Behçet's disease patients without overt neurological involvement

2004 ◽  
Vol 220 (1-2) ◽  
pp. 99-104 ◽  
Author(s):  
Roberto Monastero ◽  
Cecilia Camarda ◽  
Carmela Pipia ◽  
Gianluca Lopez ◽  
Lawrence K.C Camarda ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Behcet's Disease

scholarly journals Depression and Anxiety in Iranian Patients with Behcet's Disease: A Single Center Experience

2013 ◽  
Vol 2 (3) ◽  
pp. 100-105
Author(s):  
Mohammad Mehdi Fani ◽  
Elham Aflaki ◽  
Hooman Ebrahimi ◽  
Anahita Safari ◽  
Sina Ghanizadeh ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Control Group ◽  
Depression And Anxiety ◽  
Disease Treatment ◽  
Behcet's Disease ◽  
Single Center Experience ◽  
High Level ◽  
Anxiety Index

Background: This study was designed to determine and compare the stress, anxiety and depression levels in Behcet’s disease (BD) patients and a control group of normal individuals.Materials and Methods: One-hundred and six patients with BD were selected as cases and controls were 106 age- and sex-matched participants referred to the Shiraz Dental school clinics due to dental problems. We collected the information with 3 validated Farsi questionnaires: Perceived Stress Scale (PSS) for stress, Beck Anxiety Index (BDI) for depression and Beck Depression Index (BAI) for anxiety.Results: Stress, depression and anxiety levels were significantly higher in patients with BD in comparison with the control group (p<0.001).Conclusions: A high level of stress and depression in BD patients is frequent and PSS, BDI and BAI are useful for determining these variations. Finally, we suggest a psychiatrist consultation in all periods of disease treatment.

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