The rationale for testing drug combinations in aging intervention studies

Background: Multimorbidity is a public health concern and an essential component of aging and healthspan but understudied because investigative tools are lacking that can be translatable to capture similarities and differences of the aging process across species and variability between individuals and individual organs. Methods: To help address this need, body organ disease number (BODN) borrowed from human studies was applied to C57BL/6 (B6) and CB6F1 mouse strains at 8, 16, 24, and 32 months of age, as a measure of systems morbidity based on pathology lesions to develop a mouse PathoClock resembling clinically-based Body Clock in humans, using Bayesian inference. A mouse PhysioClock was also developed based on measures of physiological domains including cardiovascular, neuromuscular, and cognitive function in the same two mouse strains so that alignment with BODN was predictable. Results: Between- and within-age variabilities in PathoClock and PhysioClock, as well as between-strain variabilities. Both PathoClock and PhysioClock correlated with chronological age more strongly in CB6F1 than C57BL/6. Prediction models were then developed, designated as PathoAge and PhysioAge, using regression models of pathology and physiology measures on chronological age. PathoAge better predicted chronological age than PhysioAge as the predicted chronological and observed chronological age for PhysioAge were complex rather than linear. Conclusion: PathoClock and PhathoAge can be used to capture biological changes that predict BODN, a metric developed in humans, and compare multimorbidity across species. These mouse clocks are potential translational tools that could be used in aging intervention studies. Keywords: Multimorbidity, aging, pathology, physiology, pathoClock, physioClock, pathoAge, physioAge

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Nutraceutical Interventions for Promoting Healthy Aging in Invertebrate Models

Oxidative Medicine and Cellular Longevity ◽

10.1155/2012/718491 ◽

2012 ◽

Vol 2012 ◽

pp. 1-10 ◽

Cited By ~ 23

Author(s):

Yuqing Dong ◽

Sujay Guha ◽

Xiaoping Sun ◽

Min Cao ◽

Xiaoxia Wang ◽

...

Keyword(s):

Healthy Aging ◽

Intervention Studies ◽

Biological Process ◽

Biological Activities ◽

Model Organisms ◽

Dietary Interventions ◽

Aging Intervention ◽

Effective Interventions ◽

Invertebrate Models ◽

Shed Light

Aging is a complex and inevitable biological process that is associated with numerous chronically debilitating health effects. Development of effective interventions for promoting healthy aging is an active but challenging area of research. Mechanistic studies in various model organisms, noticeably two invertebrates,Caenorhabditis elegansandDrosophila melanogaster, have identified many genes and pathways as well as dietary interventions that modulate lifespan and healthspan. These studies have shed light on some of the mechanisms involved in aging processes and provide valuable guidance for developing efficacious aging interventions. Nutraceuticals made from various plants contain a significant amount of phytochemicals with diverse biological activities. Phytochemicals can modulate many signaling pathways that exert numerous health benefits, such as reducing cancer incidence and inflammation, and promoting healthy aging. In this paper, we outline the current progress in aging intervention studies using nutraceuticals from an evolutionary perspective in invertebrate models.

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Design of aging intervention studies: the NIA interventions testing program

AGE ◽

10.1007/s11357-008-9048-1 ◽

2008 ◽

Vol 30 (4) ◽

pp. 187-199 ◽

Cited By ~ 82

Author(s):

N. L. Nadon ◽

R. Strong ◽

R. A. Miller ◽

J. Nelson ◽

M. Javors ◽

...

Keyword(s):

Intervention Studies ◽

Testing Program ◽

Aging Intervention

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PathoClock and PhysioClock in mice recapitulate human multimorbidity and heterogeneous aging

10.1101/2021.10.17.464755 ◽

2021 ◽

Author(s):

Shabnam Salimi ◽

Christina Pettan-Brewer ◽

Warren Ladiges

Keyword(s):

Regression Models ◽

Intervention Studies ◽

Prediction Models ◽

Health Concern ◽

Chronological Age ◽

Mouse Strains ◽

Public Health Concern ◽

Aging Intervention ◽

Body Organ ◽

Similarities And Differences

Multimorbidity is a public health concern and an essential component of aging and healthspan but understudied because investigative tools are lacking that can be translatable to capture similarities and differences of the aging process across species and variability between individuals and individual organs. To help address this need, body organ disease number (BODN) borrowed from human studies was applied to C57BL/6 (B6) and CB6F1 mouse strains at 8, 16, 24, and 32 months of age, as a measure of systems morbidity based on pathology lesions to develop a mouse PathoClock resembling clinically-based Body Clock in humans, using Bayesian inference. A mouse PhysioClock was also developed based on measures of physiological domains including cardiovascular, neuromuscular, and cognitive function in the same two mouse strains so that alignment with BODN was predictable. The results revealed between- and within-age variabilities in PathoClock and PhysioClock, as well as between-strain variabilities. Both PathoClock and PhysioClock correlated with chronological age more strongly in CB6F1 than C57BL/6. Prediction models were then developed, designated as PathoAge and PhysioAge, using regression models of pathology and physiology measures on chronological age. PathoAge better predicted chronological age than PhysioAge as the predicted chronological and observed chronological age for PhysioAge were complex rather than linear. In conclusion, PathoClock and PhathoAge can be used to capture biological changes that predict BODN, a metric developed in humans, and compare multimorbidity across species. These mouse clocks are potential translational tools that could be used in aging intervention studies.

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Preventing Long-Term Reading Difficulties through Kindergarten and First Grade Intervention: The Case for Early Intervention

Perspectives on Language Learning and Education ◽

10.1044/lle15.1.22 ◽

2008 ◽

Vol 15 (1) ◽

pp. 22-33 ◽

Cited By ~ 4

Author(s):

Frank R. Vellutino ◽

Haiyan Zhang

Keyword(s):

Early Intervention ◽

Reading Disability ◽

Intervention Studies ◽

Intervention Study ◽

Reading Difficulties ◽

First Grade

Abstract This article reviews recent intervention studies that have provided the foundation for a variety of RTI approaches to reading disability classification and remediation. The three-tier model of RTI is defined and discussed. Selected findings from a kindergarten and first grade intervention study are summarized.

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A review of career interventions from an educational perspective: Have investigations shed any light?

Swiss Journal of Psychology ◽

10.1024//1421-0185.59.4.227 ◽

2000 ◽

Vol 59 (4) ◽

pp. 227-239 ◽

Cited By ~ 12

Author(s):

Lee-Ann Prideaux ◽

Peter A. Creed ◽

Juanita Muller ◽

Wendy Patton

Keyword(s):

Career Development ◽

Intervention Studies ◽

Future Research ◽

Development Programs ◽

Career Intervention ◽

Career Interventions ◽

International Trends ◽

Specific Career ◽

Education Interventions ◽

Development Literature

Despite widespread acknowledgement of the importance of career development programs to assist students in their complex transition from school to work, very few specific career education interventions have been objectively evaluated. The aim of this paper is to highlight what the authors consider to be a conspicuous shortfall in the career development literature to date, that is, reports of methodologically sound career intervention studies carried out in actual high school settings. International trends in the world of work are briefly discussed in association with the repercussions these changes are producing for today's youth. The major portion of this article is devoted to a comprehensive review of career intervention studies with particular attention paid to the methodological and theoretical issues that resonate from this review process. Recommendations for future research are proposed.

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