Capillary Dysfunction and CD46-immunoreceptor (CD46) Type in MS

2019 ◽  
Author(s):  
Keyword(s):  
Capillary Dysfunction

P1-310: Capillary dysfunction in Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P269-P270
Author(s):  
Leif Østergaard ◽  
Kartheeban Nagenthiraja ◽  
Louise Gyldensted ◽  
Anders Rodell ◽  
Carsten Gyldensted ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Capillary Dysfunction

scholarly journals Microcirculation: nexus of comorbidities in diabetes

2007 ◽  
Vol 293 (2) ◽  
pp. F486-F493 ◽  
Author(s):  
Constance Temm ◽  
Jesus H. Dominguez
Keyword(s):  
Metabolic Syndrome ◽  
Large Scale ◽  
Interstitial Fibrosis ◽  
Peritubular Capillary ◽  
Tubular Atrophy ◽  
The Metabolic Syndrome ◽  
Peritubular Capillaries ◽  
Obese Rats ◽  
Capillary Dysfunction

Generalized capillary dysfunction is a morbid element in the metabolic syndrome, and it is likely involved in its complications. We tested the hypothesis that vast amounts of serum albumin previously observed in kidneys of rats with the metabolic syndrome were caused, in part, by leakage from renal peritubular capillaries. We report herein large scale leaks of plasma fluid in peritubular capillaries of rats with the metabolic syndrome. This finding was directly demonstrated in vivo, and the presence of leftover albumin residue confirmed the leak in postmortem kidney specimens. Moreover, renal interstitial fibrosis and tubular atrophy were found in a distribution similar to the leaked renal albumin in obese rats. We suggest that there is an important link between peritubular capillary damage and interstitial fibrosis, represented as tubulointerstitial disease in the metabolic syndrome. We propose that maintenance of the peritubular microcirculation may improve renal outcomes in diabetes and the metabolic syndrome.

scholarly journals Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline

2015 ◽  
Vol 36 (2) ◽  
pp. 302-325 ◽  
Author(s):  
Leif Østergaard ◽  
Thorbjørn S Engedal ◽  
Fiona Moreton ◽  
Mikkel B Hansen ◽  
Joanna M Wardlaw ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Capillary Flow ◽  
Small Vessel Disease ◽  
Genetic Disorders ◽  
The Elderly ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vascular Pathology ◽  
Vessel Disease ◽  
Capillary Dysfunction

Cerebral small vessel disease (SVD) gives rise to one in five strokes worldwide and constitutes a major source of cognitive decline in the elderly. SVD is known to occur in relation to hypertension, diabetes, smoking, radiation therapy and in a range of inherited and genetic disorders, autoimmune disorders, connective tissue disorders, and infections. Until recently, changes in capillary patency and blood viscosity have received little attention in the aetiopathogenesis of SVD and the high risk of subsequent stroke and cognitive decline. Capillary flow patterns were, however, recently shown to limit the extraction efficacy of oxygen in tissue and capillary dysfunction therefore proposed as a source of stroke-like symptoms and neurodegeneration, even in the absence of physical flow-limiting vascular pathology. In this review, we examine whether capillary flow disturbances may be a shared feature of conditions that represent risk factors for SVD. We then discuss aspects of capillary dysfunction that could be prevented or alleviated and therefore might be of general benefit to patients at risk of SVD, stroke or cognitive decline.

scholarly journals Capillary dysfunction and impaired tissue oxygenation in complex regional pain syndrome: A hypothesis

Pain ◽  
2014 ◽  
Vol 155 (10) ◽  
pp. 1922-1926 ◽  
Author(s):  
Leif stergaard ◽  
Astrid Juhl Terkelsen ◽  
Nanna Brix Finnerup ◽  
Lone Knudsen ◽  
Kim Ryun Drasbek ◽  
...  
Keyword(s):  
Complex Regional Pain Syndrome ◽  
Tissue Oxygenation ◽  
Pain Syndrome ◽  
Capillary Dysfunction

Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice

2007 ◽  
Vol 292 (1) ◽  
pp. F261-F268 ◽  
Author(s):  
Liping Wu ◽  
Manish M. Tiwari ◽  
Kurt J. Messer ◽  
Joseph H. Holthoff ◽  
Neriman Gokden ◽  
...  
Keyword(s):  
Renal Failure ◽  
Adhesion Molecule ◽  
Cell Stress ◽  
Intercellular Adhesion Molecule ◽  
Intermittent Flow ◽  
Early Event ◽  
Capillary Perfusion ◽  
Peritubular Capillary ◽  
Lps Challenge ◽  
Capillary Dysfunction

The mortality rate for septic patients with acute renal failure is extremely high. Since sepsis is often caused by lipopolysaccharide (LPS), a model of LPS challenge was used to study the development of kidney injury. Intravital video microscopy was utilized to investigate renal peritubular capillary blood flow in anesthetized male C57BL/6 mice at 0, 2, 6, 10, 18, 24, 36, and 48 h after LPS administration (10 mg/kg ip). As early as 2 h, capillary perfusion was dramatically compromised. Vessels with continuous flow were decreased from 89 ± 4% in saline controls to 57 ± 5% in LPS-treated mice ( P < 0.01), and vessels with intermittent flow were increased from 6 ± 2% to 31 ± 5% ( P < 0.01). At 2 h, mRNA for intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 were elevated 50- and 27-fold, respectively, suggesting that vascular inflammation is an early event that may contribute to capillary dysfunction. By 10 h, vessels with no flow increased from 5 ± 2% in saline controls to 19 ± 3% in LPS-treated mice ( P < 0.05). By 48 h, capillary function was returning toward control levels. The decline in functional capillaries preceded the development of renal failure and was paralleled by induction of inducible nitric oxide synthase in the kidney. Using NAD(P)H autofluorescence as an indicator of cellular redox stress, we found that tubular cell stress was highly correlated with the percentage of dysfunctional capillaries ( r 2 = 0.8951, P < 0.0001). These data show that peritubular capillary dysfunction is an early event that contributes to tubular stress and renal injury.

scholarly journals Long-term probucol therapy continues to suppress markers of neurovascular inflammation in a dietary induced model of cerebral capillary dysfunction

2014 ◽  
Vol 13 (1) ◽  
pp. 91 ◽  
Author(s):  
Ryusuke Takechi ◽  
Menuka M Pallebage-Gamarallage ◽  
Virginie Lam ◽  
Corey Giles ◽  
John CL Mamo
Keyword(s):  
Cerebral Capillary ◽  
Capillary Dysfunction

scholarly journals Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype

PLoS Biology ◽  
2021 ◽  
Vol 19 (9) ◽  
pp. e3001358
Author(s):  
Virginie Lam ◽  
Ryusuke Takechi ◽  
Mark J. Hackett ◽  
Roslyn Francis ◽  
Michael Bynevelt ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Alzheimer Disease ◽  
Genetic Modification ◽  
Impaired Performance ◽  
Neurodegenerative Process ◽  
Transmission Electron ◽  
Dependent Learning ◽  
Capillary Dysfunction ◽  
Peripheral Metabolism

Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90% of Aß is complexed as an apolipoprotein, raising the possibility of a lipoprotein-mediated axis for AD risk. In this study, we report that genetic modification of C57BL/6J mice engineered to synthesise human Aß only in liver (hepatocyte-specific human amyloid (HSHA) strain) has marked neurodegeneration concomitant with capillary dysfunction, parenchymal extravasation of lipoprotein-Aß, and neurovascular inflammation. Moreover, the HSHA mice showed impaired performance in the passive avoidance test, suggesting impairment in hippocampal-dependent learning. Transmission electron microscopy shows marked neurovascular disruption in HSHA mice. This study provides causal evidence of a lipoprotein-Aß /capillary axis for onset and progression of a neurodegenerative process.

Sign in / Sign up

Export Citation Format

Share Document