Platelet Rich Plasma Injection Into Ovary of Patients With Premature Ovarian Insufficiency

2019 ◽  
Author(s):  
Keyword(s):  
Platelet Rich Plasma ◽  
Premature Ovarian Insufficiency ◽  
Ovarian Insufficiency ◽  
Plasma Injection

scholarly journals Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

2020 ◽  
Vol 9 (6) ◽  
pp. 1809 ◽  
Author(s):  
Konstantinos Sfakianoudis ◽  
Mara Simopoulou ◽  
Sokratis Grigoriadis ◽  
Agni Pantou ◽  
Petroula Tsioulou ◽  
...  
Keyword(s):  
Pilot Study ◽  
Outcome Measures ◽  
Primary Outcome ◽  
Platelet Rich Plasma ◽  
Premature Ovarian Insufficiency ◽  
Cycle Performance ◽  
Routine Practice ◽  
Ovarian Insufficiency ◽  
Pilot Studies ◽  
Pilot Data

Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot studies were conducted on poor ovarian response (POR), premature ovarian insufficiency (POI), perimenopause, and menopause, respectively. Each pilot study reports on thirty patients, 120 participants were recruited in total. All participants provided written informed consent prior to treatment. Primary outcome measures for the POR pilot study were levels of anti-müllerian hormone (AMH), antral follicle count (AFC) and oocyte yield. For the POI, perimenopausal and menopausal pilot studies primary outcome measures were restoration of menstrual cycle, and Follicle Stimulating Hormone (FSH) levels. A significant improvement on the hormonal profile and the ovarian reserve status was noted, along with improved intracytoplasmic sperm injection (ICSI) cycle performance concerning POR participants. Menstruation recovery was observed in 18 out of 30 POI patients, along with a statistically significant improvement on levels of AMH, FSH, and AFC. Similarly, 13 out of 30 menopausal women positively responded to PRP treatment. Finally, menstruation regularity, improved hormonal levels and AFC were reported for 24 out of 30 perimenopausal women. To conclude, PRP infusion appears to convey promising results in addressing ovarian insufficiency.

scholarly journals Laparoscopic intra-ovarian platelet rich plasma injection for ovarian rejuvenation: a new hope for infertile women

2020 ◽  
Vol 9 (10) ◽  
pp. 4320
Author(s):  
Mohamed Farag El Sherbeny
Keyword(s):  
Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Platelet Rich Plasma ◽  
Ovarian Insufficiency ◽  
Hormonal Profile ◽  
Infertile Women ◽  
Plasma Injection ◽  
Natural Treatment ◽  
Gestational Week ◽  
Vaginal Ultrasonography

This case report was presented to show the outcome of bilateral laparoscopic platelet rich plasma intra-ovarian injection for 34-year old woman who had primary infertility secondary to premature ovarian insufficiency and had two previously failed attempts of ICSI. One month after the procedure, the patient had menses and her hormonal profile was improved with increased serum AMH and E2 and decreased serum FSH and LH. On the eleventh day of the menstrual cycle, folliculometry detected good follicle measuring 18×20 mm, on the fifteenth day, trans-vaginal ultrasonography assured ovulation and timed intercourse was ordered, and she got pregnant. At the thirty fifth gestational week, she had premature preterm rupture of membrane and urgent cesarean delivery was performed and the newborn was admitted to neonatal intensive care unit. As conclusion, intra-ovarian PRP injections could be safe, productive, and a natural treatment for women with POI. Laparoscopic injection allowed perfect under-vision intra-ovarian injection and can be conducted as one-day procedure and this can be considered a novelty of the applied procedure.

scholarly journals Restoration of Fertility in Patients with Spontaneous Premature Ovarian Insufficiency: New Techniques under the Microscope

2021 ◽  
Vol 10 (23) ◽  
pp. 5647
Author(s):  
Marie Mawet ◽  
Sophie Perrier d’Hauterive ◽  
Laurie Henry ◽  
Iulia Potorac ◽  
Frédéric Kridelka ◽  
...  
Keyword(s):  
Statistical Power ◽  
Animal Studies ◽  
Platelet Rich Plasma ◽  
Fertility Restoration ◽  
Premature Ovarian Insufficiency ◽  
Ovarian Insufficiency ◽  
Pubmed Database ◽  
Autologous Platelet Rich Plasma ◽  
Study Designs

Premature ovarian insufficiency (POI), a condition affecting up to 1% of women by the age of 40 years, is characterized by an extremely low chance of spontaneous pregnancy. Currently, fertility restoration options are virtually nonexistent for this population. To become pregnant, the only solution is egg donation. Interestingly, animal studies have provided encouraging results in terms of fertility restoration, and consequently, research has begun into the most promising approaches for women suffering from POI. The PubMed database was searched for studies in which techniques aiming at restoring fertility in women with spontaneous POI were tested. Although robust studies are lacking, the literature suggests a positive effect of certain techniques on fertility restoration in women with POI. The most promising approaches seem to be intraovarian injection of autologous platelet-rich plasma or of mesenchymal stem cells. In addition to these, in vitro and mechanical activation of dormant follicles and etiology-driven therapies have also been studied with mixed results. No safety concerns were raised in these studies. The absence of robust studies does not allow us to draw meaningful conclusions on the efficacy or superiority of any single technique at this stage, and so research in this area should continue using robust study designs, i.e., multicenter randomized controlled trials including sufficient subjects to achieve statistical power.

scholarly journals Intraovarian platelet-rich plasma: current status

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Aboubakr Mohamed Elnashar
Keyword(s):  
Ovarian Reserve ◽  
Reproductive Medicine ◽  
Platelet Rich Plasma ◽  
Case Series ◽  
Ovarian Response ◽  
Diminished Ovarian Reserve ◽  
Premature Ovarian Insufficiency ◽  
Current Status ◽  
Poor Responders ◽  
Ovarian Insufficiency

Abstract Background The successful use of PRP in regenerative medicine has led investigators to study its effect in the treatment of conditions like decreased ovarian reserve, poor responders, and premature ovarian insufficiency. Objective To review the uses of intraovarian PRP in reproductive medicine. Methods A literature search for English articles related to the uses of intraovarian PRP in reproductive medicine, including articles published in PubMed, from 2000 to April 2021. Results Seventeen studies: No RCT. Studies were classified according to indication. (1) For diminished ovarian reserve: 6 studies including 369 patients. (2). For poor responders: 3 case series studies including 41 patients with an improvement in ovarian response. (3) For premature ovarian insufficiency: 8 studies including 373 patients. Ovarian reserve markers were the outcome of all studies with conflicting results. LBR was not determined in the majority of studies. Conclusion Intraovarian PRP for diminished ovarian reserve, poor ovarian response, or POI is still experimental. Well-designed, large RCTS to confirm its efficacy and safety are required.

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