Vortioxetine in Patients With Depression and Early Dementia

Author(s):  
Keyword(s):  
2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Lin Zhu ◽  
Lihe Huang

Verbal repetition has been acknowledged as one of the most common symptoms in early Dementia of Alzheimer's Type (DAT). Despite previous attempts, the applicability of verbal repetition as an essential linguistic marker indicating this disease remains unexplored for Chinese DAT patients. This study collects Chinese DAT patients' daily conversation data to investigate both structural and functional aspects of pathological verbal repetition. Three major types are set regarding the cases of pathological repetition, respectively ‘unconscious concept repetition', ‘perseveration', and ‘involuntary word repetition'. The analysis focuses on what features these repetitions have from the perspective of ‘ideational function', ‘interpersonal function', and ‘textual function' within the framework of Systemic Functional Linguistics. A better understanding of pathological verbal repetition by DAT elders as the linguistic markers of cognitive impairment promotes effective communication between patients, nursing staff, and family members.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mihály Racsmány ◽  
Dorottya Bencze ◽  
Péter Pajkossy ◽  
Ágnes Szőllősi ◽  
Miklós Marián

AbstractOne of the greatest commonplaces in memory research is that context improves recall and enhances or leaves recognition intact. Here we present results which draw attention to the fact that the reappearance of irrelevant and unattended background contexts of encoding significantly impairs memory discrimination functions. This manuscript presents the results of two experiments in which participants made indoor/outdoor judgements for a large number of object images presented together with individual, irrelevant and presumably unattended background scenes. On a subsequent unexpected recognition test participants saw the incidentally encoded target objects, visually similar lures or new foil objects on the same or new background scenes. Our results showed that although the reappearance of the background scene raised the hit rate for target objects, it decreased mnemonic discrimination, a behavioral score for pattern separation, a hippocampal function that is affected in early dementia. Furthermore, the presence of the encoded background scene at the recognition test increased the false recognition of lure objects, even when participants were explicitly instructed to neglect the context scene. Altogether these results gave evidence that if context increases recognition hits for target memories, it does so at the cost of increasing false recognition and diminished discriminability for similar information.


2015 ◽  
Vol 40 (1-2) ◽  
pp. 63-71 ◽  
Author(s):  
Casper de Boer ◽  
Johan J.M. Pel ◽  
Johannes van der Steen ◽  
Francesco Mattace-Raso

Background/Aims: Recent evidence shows that early dementia patients have deficits in manual reaching tasks. It is important to understand the impact of these functional disabilities on their quality of life. The aim of this study was to investigate if there is an association between manual reaching and measures of (instrumental) activities of daily living (IADL) in a group of patients with cognitive complaints. Methods: The manual reaching performance of 27 patients was assessed in detail with eye and hand tracking devices. Patients were divided into three groups based on self-reported loss of IADL function. Parameters describing hand response and movement times were compared between groups. Results: Patients with loss of IADL function in ≥1 domain had delayed hand response and hand movement times towards visible targets compared to patients with no loss of IADL function. Conclusion: Delays in manual reaching movements are related to the degree of loss of IADL function in early dementia patients.


2003 ◽  
Vol 16 (3) ◽  
pp. 151-155 ◽  
Author(s):  
Brian R. Ott ◽  
William C. Heindel ◽  
William M. Whelihan ◽  
Mark D. Caron ◽  
Andrea L. Piatt ◽  
...  

1902 ◽  
Vol 2 (9) ◽  
pp. 480-481
Author(s):  
V. Serbskiy

In the first part of his article, the author examines the current state of the issue of secondary dementia and proves that a group of psychoses, known under the name secondary dementia, should be left in the classification of mental illnesses. The second part is devoted to the analysis of Krpelin's scholarship on dementia praecox, and the author fundamentally disagrees with many of the provisions of the latter. In the third part, the ethiology, clinical course and recognition of premature dementia are analyzed.


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