Squamous Cell Carcinoma of the Thyroid Gland in an elderly Female

Background: Squamous cell carcinoma of the thyroid gland is a rare tumor. The tumor may arise as a primary tumor within the thyroid gland. Case Presentation: A 62-years-old lady with history a history of a long-standing left neck mass presented with progressive enlargement of the mass for the last 2 months. The mass was associated with dyspnea, dry cough, and difficulty in swallowing but no change of voice. On examination, it was hard and fixed, and other parts of the general examination were unremarkable. Fine needle aspiration revealed malignant cells with squamous cell cancer (BETHESDA VI). On surgical exploration, there was a mixed cystic and solid mass arising from the left thyroid gland locally invading strap muscles, esophagus and trachea. Complete excision was not possible, debulking was done with modified radical neck dissection. The histopathology showed Invasive poorly differentiated squamous cell carcinoma of the thyroid with cystic changes in background of Hashimoto’s thyroiditis. Conclusion: Thyroid squamous cell carcinoma is a rare malignancy with significant management implications. Less than three hundred clear cases of thyroid squamous cell carcinoma have been reported. In this report we describe one additional case of a thyroid squamous cell carcinoma and provide a comprehensive discussion of the clinical significance, and appropriate surgical management.

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A Case of Primary Squamous Cell Carcinoma of The Thyroid Gland

Korean Society for Head and Neck Oncology ◽

10.21593/kjhno/2021.37.2.91 ◽

2021 ◽

Vol 37 (2) ◽

pp. 91-95

Author(s):

Sihyung Kang ◽

Gi Cheol Park

Keyword(s):

Squamous Cell Carcinoma ◽

Thyroid Gland ◽

Cell Carcinoma ◽

Squamous Cell ◽

Neck Mass ◽

Rapid Progression ◽

Selective Neck Dissection ◽

Primary Squamous Cell Carcinoma ◽

Aggressive Clinical Course ◽

Painful Neck

Primary squamous cell carcinoma of thyroid is a very rare malignant tumor with poor prognosis. It is usually diagnosed as an advanced disease infiltrating adjacent organs, and characterized by aggressive clinical course with an average postoperative survival time of less than 1 year. Recently, we had a 79- year-old woman with a painful neck mass who was diagnosed as primary squamous cell carcinoma of thyroid gland. She underwent total thyroidectomy and selective neck dissection(level Ⅲ, Ⅵ) with no further postoperative managements such as radiation therapy or chemotherapy; she died of poor general condition and pneumonia resulting from rapid progression of the lesion on the 38th day after surgery. We report this case with a review of relevant literatures.

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Primary squamous cell carcinoma of the thyroid-case report of a rare disease

Endocrinology and Disorders ◽

10.31579/2640-1045/057 ◽

2020 ◽

Vol 4 (2) ◽

pp. 01-04

Author(s):

Lévay Bernadett

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Thyroid Gland ◽

Cell Carcinoma ◽

Squamous Cell ◽

Vocal Cord Palsy ◽

Neck Mass ◽

Primary Squamous Cell Carcinoma ◽

Adequate Treatment ◽

Disease Case

Introduction: Primary squamous cell carcinoma (SCC) of the thyroid gland is a very rare entity. The prognosis is very poor with a short survival time. The aim of this article is to report a case of a SCC of the thyroid gland in a 68-year-old woman, emphasizing how complicate is the operation and the adequate treatment of this disease. Case Report: A 68-year -old woman presented with rapidly growing neck mass with hoarseness and compressive symptoms. Physical examination revealed a hard fixed tumor with right sided vocal cord palsy. Histopathological result confirmed the diagnosis of SCC of the thyroid. PET/CT scan excluded the possibility of other primary malignancies. A surgical intervention was performed, however the patient died in the middle of the palliative radiation therapy. Conclusion: SCC of the thyroid gland is a great challenge for the surgeon and also for the multidisciplinary team to come up with the best treatment option which is suitable for the patient due to its unfavorable prognosis.

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THYROID METASTASIS OF A SQUAMOUS CELL CARCINOMA OF THE TONGUE - A RARE CASE REPORT

Journal of IMAB - Annual Proceeding (Scientific Papers) ◽

10.5272/jimab.2021271.3564 ◽

2021 ◽

Vol 27 (1) ◽

pp. 3564-3567

Author(s):

Gergana Tosheva ◽

◽

Mira Siderova ◽

Elitsa Encheva ◽

Doroteya Malinova ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Thyroid Gland ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cell Cancer ◽

University Hospital ◽

Cervical Lymph Nodes ◽

Carcinoma Of The Tongue

Introduction: We present a patient with carcinoma of the tongue with а lymph node and thyroid metastasеs. The squamous cell cancer of the tongue’s 5-year survival rate has not been improved in the last three decades. Most common sites of metastases are the locoregional lymph nodes, followed by distant pulmonary, liver, bone and skin metastasеs. Only ten cases of metastases to the thyroid gland are reported in the literature. Case report: A 79-year old man presented to the University Hospital in Varna, Bulgaria. Two months before admission, he noticed swelling of the tongue and progressive weight loss. The inspection of the oral cavity revealed a lesion on the left margin of the tongue. A biopsy was performed with a histological result of differentiated squamous cell carcinoma of the tongue. A computed tomography scan of the head and neck region discovered a lesion in the right thyroid lobe. 18-fluoro-2-deoxy-glucose-positron emission tomography imaging showed a metabolically active tumor of the tongue with hypermetabolic metastatic cervical lymph nodes and a zone with abnormally elevated fixation of 18F-FDG in the central part of the soft palate. The described thyroid nodule did not have an increased tracer uptake. It was cytologically assessed after fine-needle aspiration biopsy (FNAB) as a metastasis from squamous cell carcinoma of the tongue. Conclusions: Distant metastases from tongue cancer to the thyroid gland are extremely rare and mostly occur in the advanced stages of malignancy.

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Not all neck mass fine-needle aspirations with squamous cells are squamous cell carcinoma; report of a case of recurrent thyroid carcinoma with papillary and squamous components

CytoJournal ◽

10.4103/cytojournal.cytojournal_19_17 ◽

2018 ◽

Vol 15 ◽

pp. 23

Author(s):

Katie Dennis ◽

Maura O'Neil ◽

Anthony Harrington

Keyword(s):

Squamous Cell Carcinoma ◽

Thyroid Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Clinical History ◽

Needle Aspiration ◽

Neck Mass ◽

Braf V600e ◽

Fine Needle ◽

Poor Outcomes

We report a case of a 65-year-old female who had a total thyroidectomy 12 years ago for papillary thyroid carcinoma (PTC) who presented with a recurrent thyroid bed mass. Fine-needle aspiration biopsy yielded malignant cells, consistent with squamous cell carcinoma (SCCa). Surgical resection was performed, and histologic evaluation of the mass showed mixed PTC and SCCa. The tumor cells were positive for BRAF V600E mutation. Thyroid carcinomas with admixed papillary carcinoma and SCCa are rare and are associated with aggressive behavior, high rates of metastasis, and poor outcomes. Although SCCa presenting as a neck mass is relatively common, clinical history and appropriate workup are essential for accurate diagnosis and determination of origin.

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Primary Squamous Cell Carcinoma of Thyroid: A case Report

Nepalese Journal of ENT Head and Neck Surgery ◽

10.3126/njenthns.v6i1.19440 ◽

2018 ◽

Vol 6 (1) ◽

pp. 22-24

Author(s):

Ishwor Raj Devkota ◽

Dipendra Shrestha ◽

Subash Khadka

Keyword(s):

Squamous Cell Carcinoma ◽

Thyroid Gland ◽

Cell Carcinoma ◽

Squamous Cell ◽

Poor Prognosis ◽

Needle Aspiration ◽

Primary Squamous Cell Carcinoma ◽

Aspiration Cytology ◽

Right Lobe ◽

Needle Aspiration Cytology

Background: The thyroid gland lacks the squamous cell and the primary squamous cell carcinoma (SCC) of the thyroid gland is an uncommon malignancy with less than 1 % of all thyroid malignancy with a very poor prognosis. So far few cases are reported in the literature with very low survival rates.Case report: A 60 years female presented with a rapidly enlarging right lobe of the thyroid with pain, dysphagia and hoarseness of two months duration. She had hard fixed 4cm x 4cm right lobe of thyroid with right vocal cord paralysis. Ultrasound demonstrates 36mm x 36mm right lobe with mixed echogenicity with calcifications. Fine needle aspiration cytology suggested anaplastic carcinoma. Computed tomography showed heterogeneously enhancing soft tissue density in the right lobe of the thyroid gland measuring 51mm x 37mm x 53mm with shifting of the trachea towards the left side with no significant cervical lymph nodes. CT chest, ultrasonography abdomen and pelvis did not reveal any primary lesion or other metastatic disease and stage was made as T4N0M0. Patient underwent total thyroidectomy with center neck clearance with temporary tracheostomy. Histopathology came out to be squamous cell carcinoma and patient was send for chemo-radiotherapy.Conclusion: Primary squamous cell carcinoma of thyroid is a rare and aggressive entity with poor prognosis. Fine needle aspiration cytology is effective confirmatory tool but efforts shall be made to rule out metastatic SCC originating from other sites. Surgery, radiotherapy and chemotherapy alone are ineffective. Aggressive treatment with surgery followed by adjuvant radiotherapy with or without chemotherapy is recommended to achieve better outcome.Nepalese Journal of ENT Head and Neck Surgery, Vol. 6, No. 1, 2015

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Immunohistochemical Features of Primary Pure Squamous Cell Carcinoma in the Thyroid: An Autopsy Case

Case Reports in Oncology ◽

10.1159/000490410 ◽

2018 ◽

Vol 11 (2) ◽

pp. 418-424 ◽

Cited By ~ 5

Author(s):

Satoshi Koyama ◽

Kazunori Fujiwara ◽

Kanae Nosaka ◽

Takahiro Fukuhara ◽

Tsuyoshi Morisaki ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cervical Lymphadenopathy ◽

Distant Metastases ◽

Needle Aspiration ◽

Neck Mass ◽

Thyroid Tumor ◽

Cervical Lymph Nodes

Primary squamous cell carcinoma (SCC) in the thyroid is extremely rare and has been reported in < 1% of all thyroid cancer cases. Primary SCC in the thyroid was thought to be a transitional form derived from adenocarcinomas; therefore, the majority of reported cases have focused on the conjunction with other histological adenocarcinomas. A 73-year-old male presented to our hospital with bilateral vocal fold palsy and an anterior neck mass. Ultrasound sonography revealed a bulky tumor in the thyroid and bilateral cervical lymphadenopathy. We performed fine-needle aspiration cytology from the thyroid tumor, which revealed SCC. Positron emission tomography/computed tomography showed distant metastases in the lungs, mediastinal lymph nodes, and vertebra. We diagnosed the patient as having stage IVC SCC in the thyroid and administered weekly paclitaxel. Four and a half months after treatment initiation, the tumor progression resulted in aspiration pneumonia, which proved fatal. We performed an autopsy in accordance with the patient’s wishes. Pathological findings revealed that all carcinomas in the thyroid, cervical lymph nodes, and lungs were pure SCCs. Immunohistochemical examinations for PAX8, thyroglobulin, and TTF-1 were all negative. Differentiated thyroid carcinomas have 3 major positive markers – PAX8, thyroglobulin, and TTF-1 –, and PAX8 is also sometimes positive for SCC in the thyroid. PAX8 positivity of SCC in the thyroid might, however, be associated with conjunction with other histological adenocarcinomas such as papillary or follicular thyroid carcinoma; therefore, pure SCC in the thyroid might be negative for PAX8.

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Squamous Cell Carcinoma Lung Presenting as a Painful Thigh Mass: A Case Report

JMS SKIMS ◽

10.33883/jms.v17i2.245 ◽

2014 ◽

Vol 17 (2) ◽

pp. 71-73

Author(s):

Syed Besina ◽

Othman Salim Akhtar ◽

Nazir Bhat ◽

Tazeen Jeelani Samoon

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Fine Needle Aspiration Biopsy ◽

Left Lung ◽

Needle Aspiration ◽

Left Thigh ◽

Complete Excision ◽

Painful Thigh

A 75 year old male presented with a painful swelling in the left thigh. Fine needle aspiration biopsy performed revealed the presence of a Squamous cell carcinoma, prompting further evaluation. This led to the identification of an upper zone mass in the left lung which was excised; intra-operative squash cytology revealing the presence of a Squamous cell carcinoma. The patient then underwent a complete excision of the thigh swelling. Three months after the surgery, the patient died of a stroke. We report this case on account of its rarity and to highlight the role of intra-operative squash cytology in establishing the diagnosis of such lesions. JMS 2014;17(2):71-73

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Laryngeal squamous cell carcinoma presenting as a prelaryngeal, air-filled structure (pseudolaryngocoele)

The Journal of Laryngology & Otology ◽

10.1017/s0022215107007864 ◽

2007 ◽

Vol 122 (5) ◽

pp. 535-537 ◽

Cited By ~ 1

Author(s):

T S Korampalli ◽

A Belloso ◽

P S Hans ◽

K Irion ◽

I J Sheppard

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Histopathological Examination ◽

Anterior Commissure ◽

Thyroid Cartilage ◽

Needle Aspiration ◽

Neck Mass ◽

Computed Tomography Scanning

AbstractObjective:We report a unique case of a squamous cell carcinoma of the larynx presenting as a large pseudolaryngocoele, arising through a thyroid cartilage defect.Method:Case report and review of the literature.Case report:A 47-year-old man presented with a two-month history of hoarseness and a large, midline neck swelling. Endoscopic examination revealed a transglottic carcinoma involving the anterior commissure. Fine needle aspiration of the neck mass showed it to be an air-filled structure which transiently collapsed but refilled within minutes. Subsequent computed tomography scanning and histopathological examination revealed that the air-filled mass was created by a defect in the thyroid cartilage, with formation of a pseudolaryngocoele.Conclusions:The anatomy of the anterior commissure region and its effect on the spread of laryngeal carcinoma is reviewed in order to explain the pathophysiology of this unusual presentation. We highlight the need for a high index of suspicion of malignancy if a laryngocoele or pseudolaryngocoele is detected clinically.

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Pan-ERBB kinase inhibition augments CDK4/6 inhibitor efficacy in oesophageal squamous cell carcinoma

Gut ◽

10.1136/gutjnl-2020-323276 ◽

2021 ◽

pp. gutjnl-2020-323276

Author(s):

Jin Zhou ◽

Zhong Wu ◽

Zhouwei Zhang ◽

Louisa Goss ◽

James McFarland ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Large Scale ◽

Cell Cancer ◽

Oesophageal Squamous Cell Carcinoma ◽

Squamous Cancer ◽

Striking Success

ObjectiveOesophageal squamous cell carcinoma (OSCC), like other squamous carcinomas, harbour highly recurrent cell cycle pathway alterations, especially hyperactivation of the CCND1/CDK4/6 axis, raising the potential for use of existing CDK4/6 inhibitors in these cancers. Although CDK4/6 inhibition has shown striking success when combined with endocrine therapy in oestrogen receptor positive breast cancer, CDK4/6 inhibitor palbociclib monotherapy has not revealed evidence of efficacy to date in OSCC clinical studies. Herein, we sought to elucidate the identification of key dependencies in OSCC as a foundation for the selection of targets whose blockade could be combined with CDK4/6 inhibition.DesignWe combined large-scale genomic dependency and pharmaceutical screening datasets with preclinical cell line models, to identified potential combination therapies in squamous cell cancer.ResultsWe identified sensitivity to inhibitors to the ERBB family of receptor kinases, results clearly extending beyond the previously described minority of tumours with EGFR amplification/dependence, specifically finding a subset of OSCCs with dual dependence on ERBB3 and ERBB2. Subsequently. we demonstrated marked efficacy of combined pan-ERBB and CDK4/6 inhibition in vitro and in vivo. Furthermore, we demonstrated that squamous lineage transcription factor KLF5 facilitated activation of ERBBs in OSCC.ConclusionThese results provide clear rationale for development of combined ERBB and CDK4/6 inhibition in these cancers and raises the potential for KLF5 expression as a candidate biomarker to guide the use of these agents. These data suggested that by combining existing Food and Drug Administration (FDA)-approved agents, we have the capacity to improve therapy for OSCC and other squamous cancer.

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Primary squamous cell carcinoma of the pancreas with a large pseudocyst of the pancreas as the first manifestation: a rare case report and literature review

BMC Gastroenterology ◽

10.1186/s12876-021-01804-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xia Qiu ◽

Yajie Meng ◽

Meiqin Lu ◽

Chuan Tian ◽

Min Wang ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cell Mass ◽

Elevated Serum ◽

Abdominal Distension ◽

Needle Aspiration ◽

Pancreatic Pseudocysts ◽

Primary Squamous Cell Carcinoma ◽

Ki 67

Abstract Background Primary squamous cell carcinoma (SCC) of the pancreas with pseudocysts, especially diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), is extremely rare. Case presentation A 64-year-old man was admitted to our department for abdominal distension. Two months ago, he experienced abdominal pain for 1 day and was diagnosed with acute pancreatitis in another hospital. After admission, laboratory tests showed the following: amylase 400 U/L, lipase 403 U/L, and carbohydrate antigen 19–9 (CA19-9) 347 U/mL. Abdominal computed tomography (CT) revealed pancreatitis with a pseudocyst with a diameter measuring 7 cm. During linear EUS, a large pseudocyst (5.4 × 5.2 cm) was observed in the pancreatic body. EUS-FNA was performed. We obtained specimens for histopathology and placed a plastic stent through the pancreas and stomach to drain the pseudocyst. Puncture fluid examination revealed the following: CA19-9 > 12,000 U/mL carcinoembryonic antigen (CEA) 7097.42 ng/ml, amylase 27,145.3 U/L, and lipase > 6000 U/L. Cytopathology revealed an abnormal cell mass, and cancer was suspected. Furthermore, with the result of immunohistochemistry on cell mass (CK ( +), P40 ( +), p63 ( +), CK7 (−) and Ki-67 (30%)), the patient was examined as squamous cell carcinoma (SCC). However, the patient refused surgery, radiotherapy and chemotherapy. After drainage, the cyst shrank, but the patient died 3 months after diagnosis due to liver metastasis and multiple organ failure. Conclusion For patients with primary pancreatic pseudocysts with elevated serum CEA and CA19-9 levels, we should not rule out pancreatic cancer, which may also be a manifestation of primary pancreatic SCC. EUS-FNA is helpful for obtaining histopathology and cytology and thus improving diagnostic accuracy.

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