The department of biochemistry is the oldest basic sciencedepartment at the Albert Einstein College of Medicine. Its firstchair, who was also the first faculty member to be appointed tothe medical school itself, was hired in 1952, three years beforethe fledgling institution opened its doors to the first enteringclass. Since those early days, the department has helpedshape the academic environment of the college, influencingthe selection of departmental chairs, guiding medical schooladmissions, and teaching courses that laid the foundation forthe medical school curriculum. In this article, we summarizebriefly the history of the department from its inception to thepresent. We review the accomplishments of each of its threechairs and discuss how the department has helped define thecharacter of the institution as a whole.