A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating

When processing current sensory inputs, animals refer to related past experiences. Current information is then incorporated into the related neural network to update previously stored memories. However, the neuronal mechanism underlying the impact of memories of prior experiences on current learning is not well understood. Here, we found that a cellular ensemble in the posterior parietal cortex (PPC) that is activated during past experience mediates an interaction between past and current information to update memory through a PPC-anterior cingulate cortex circuit in mice. Moreover, optogenetic silencing of the PPC ensemble immediately after retrieval dissociated the interaction without affecting individual memories stored in the hippocampus and amygdala. Thus, a specific subpopulation of PPC cells represents past information and instructs downstream brain regions to update previous memories.

Oncologic patients’ misconceptions may impede enrollment into clinical trials: a cross-sectional study

Background Clinical trials are an essential source for advances in oncologic care, yet the enrollment rate is only 2-4%. Patients' reluctance to participate is an important barrier. This study evaluates patients' level of understanding and attitudes towards clinical trials. Methods This cross-sectional study was conducted in the oncology department and day care unit at the oncology division Tel Aviv Sourasky Medical Center, Israel. From January 2015 to September 2016. Two-hundred patients’ currently receiving active anti-cancer therapy at a large tertiary hospital completed an anonymous questionnaire comprised of demographic information, past experience in clinical research and basic knowledge on clinical trials. Results The majority of respondents did not meet the minimum knowledge level criteria. In those who replied they would decline to participate in a clinical trial, concern were related to potential assignment to the placebo arm, provision of informed consent and trust issues with their oncologist. Those with sufficient knowledge were significantly more interested in participating. Patients with past experience in clinical trials had a higher level of academic education, were less religious, had a better understanding of medical research and were inclined to participate in future research. Conclusions Misperceptions of clinical trials may contribute substantially to the unwillingness to participate in them.

My Reading and Writing Experiences: Snowball

Whenever I thought back on my past experience of learning to read and write, I found that this process was like snowballing. I was very grateful to the several English teachers I had met since my childhood. They had appeared at different stages of my life and had seen me grow. If my goal in life was to roll a big snowball, then they were undoubtedly the biggest help in my life.

Educational psychology, an outline of the major trends in its development

A characteristic peculiar ta the 20th century has been the emphasis placed upon psychology. Significant recent advances in the physical sciences have been mainly <div>applications of past experience and methods of research in the particular field. The psychological implications of the recent advances in physical sciences for human welfare, human nature and human experience that have manifested themselves in our time, are new. Interest in these implications pervades all institutions, industrial, educational, medical, economical, among them, and introduces an increasing accuracy into our insights of human behaviour. So new is the psychological development that complete ordering of the boundaries of the branches and aspects of psychological data has yet to be achieved. A variety of areas is being developed, with constant readjustment of relations between developed areas, and as it continues, the scientifically verifiable background knowledge of education accumulates.</div>

Educational psychology, an outline of the major trends in its development

A characteristic peculiar ta the 20th century has been the emphasis placed upon psychology. Significant recent advances in the physical sciences have been mainly <div>applications of past experience and methods of research in the particular field. The psychological implications of the recent advances in physical sciences for human welfare, human nature and human experience that have manifested themselves in our time, are new. Interest in these implications pervades all institutions, industrial, educational, medical, economical, among them, and introduces an increasing accuracy into our insights of human behaviour. So new is the psychological development that complete ordering of the boundaries of the branches and aspects of psychological data has yet to be achieved. A variety of areas is being developed, with constant readjustment of relations between developed areas, and as it continues, the scientifically verifiable background knowledge of education accumulates.</div>

Decentralisation of Public Enterprises in federal countries

To bring concepts and knowledge to bear more effectively on policy analysis and programme design, a framework for analysis is needed that focuses on alternatives for organising and financing the State Owned Enterprises (SOEs). Whether the motivating force behind organisation of SOEs is political or economic, a developing country situation demands that the strategy be looked at from the perspective of the provision of the people’s needs. The paper looks at the forms of SOEs and the relevance of fiscal federalism in this context. Past experience has some lessons and a flawed policy can have unwelcome consequences. Keeping in view the different initial conditions, strategies need to be devised for organisation of SOEs.

What are the chances? How descriptions of probability affect risky decisions

<p>People make different decisions when they know the odds of an event occurring, (e.g. told 10% chance of an earthquake that year) than when they draw on only their own experience (e.g. living in a city with, on average, one earthquake every 10 years). It may be that when we make decisions based on our past experience (decisions from experience) we are more likely to choose a risky option when it can lead to the biggest win and avoid it when it can lead to the biggest loss, this effect is called the Extreme-Outcome rule. Across three Experiments we tested the Extreme-Outcome rule by having participants make repeated choices between either safe or risky options which had the same expected value. In each experiment, we varied the magnitude of the reinforcer’s participants could win in both an Experience condition and a condition that had both description and experience information. In Experiment 1 where we had two reinforcer sizes (small and large) we found an Extreme-Outcome effect in the Experience condition, but not the Description-Experience condition. In Experiment 2 we tested a prediction of the Extreme-Outcome rule that participants would be sensitive to the best and worst outcome by adding another reinforcer size (reinforcers were small, medium and large) and therefore on some trials neither alternative included an extreme outcome. We also removed zero as a potential outcome to investigate whether zero aversion might be driving the effect of reinforcer magnitude in the Experience condition. We did not find response patterns consistent with an Extreme-Outcome rule in the Experience condition. Instead, participants were least risk seeking when the reinforcer was small, but there was no difference in levels of risk seeking between the medium and large reinforcer trials. In other words, there was an effect of the low-extreme outcome but not the high-extreme outcome. Like Experiment 1, in the Description-Experience condition risk preference was not influenced by reinforcer size, but the absolute levels were higher. To investigate whether this increase in risk preference was due to removing the zero, in Experiment 3 we manipulated whether zero was present or absent. When zero was absent, risk preference was not influenced by the size of the reinforcer in the Description-Experience condition, but there was an effect of the low-extreme outcome when zero was present. We also found an effect of the low extreme outcome in the Experience condition regardless of whether zero was present or absent. Overall, these findings suggest the Extreme-Outcome rule needs to be modified to take into account the effect of the low extreme but not the high extreme outcome.</p>

What are the chances? How descriptions of probability affect risky decisions

<p>People make different decisions when they know the odds of an event occurring, (e.g. told 10% chance of an earthquake that year) than when they draw on only their own experience (e.g. living in a city with, on average, one earthquake every 10 years). It may be that when we make decisions based on our past experience (decisions from experience) we are more likely to choose a risky option when it can lead to the biggest win and avoid it when it can lead to the biggest loss, this effect is called the Extreme-Outcome rule. Across three Experiments we tested the Extreme-Outcome rule by having participants make repeated choices between either safe or risky options which had the same expected value. In each experiment, we varied the magnitude of the reinforcer’s participants could win in both an Experience condition and a condition that had both description and experience information. In Experiment 1 where we had two reinforcer sizes (small and large) we found an Extreme-Outcome effect in the Experience condition, but not the Description-Experience condition. In Experiment 2 we tested a prediction of the Extreme-Outcome rule that participants would be sensitive to the best and worst outcome by adding another reinforcer size (reinforcers were small, medium and large) and therefore on some trials neither alternative included an extreme outcome. We also removed zero as a potential outcome to investigate whether zero aversion might be driving the effect of reinforcer magnitude in the Experience condition. We did not find response patterns consistent with an Extreme-Outcome rule in the Experience condition. Instead, participants were least risk seeking when the reinforcer was small, but there was no difference in levels of risk seeking between the medium and large reinforcer trials. In other words, there was an effect of the low-extreme outcome but not the high-extreme outcome. Like Experiment 1, in the Description-Experience condition risk preference was not influenced by reinforcer size, but the absolute levels were higher. To investigate whether this increase in risk preference was due to removing the zero, in Experiment 3 we manipulated whether zero was present or absent. When zero was absent, risk preference was not influenced by the size of the reinforcer in the Description-Experience condition, but there was an effect of the low-extreme outcome when zero was present. We also found an effect of the low extreme outcome in the Experience condition regardless of whether zero was present or absent. Overall, these findings suggest the Extreme-Outcome rule needs to be modified to take into account the effect of the low extreme but not the high extreme outcome.</p>

Using Immersive Virtual Reality to Examine How Visual and Tactile Cues Drive the Material-Weight Illusion

The material-weight illusion (MWI) demonstrates how our past experience with material and weight can create expectations that influence the perceived heaviness of an object. Here we used mixed-reality to place touch and vision in conflict, to investigate whether the modality through which materials are presented to a lifter could influence the top-down perceptual processes driving the MWI. University students lifted equally-weighted polystyrene, cork and granite cubes whilst viewing computer-generated images of the cubes in virtual reality (VR). This allowed the visual and tactile material cues to be altered, whilst all other object properties were kept constant. Representation of the objects’ material in VR was manipulated to create four sensory conditions: visual-tactile matched, visual-tactile mismatched, visual differences only and tactile differences only. A robust MWI was induced across all sensory conditions, whereby the polystyrene object felt heavier than the granite object. The strength of the MWI differed across conditions, with tactile material cues having a stronger influence on perceived heaviness than visual material cues. We discuss how these results suggest a mechanism whereby multisensory integration directly impacts how top-down processes shape perception.