scholarly journals Electrical Stimulation of the Lateral Part of the Dorsal Parabrachial Nucleus Causes Hyperglycemia

1987 ◽  
Vol 3 (3) ◽  
pp. 209-216 ◽  
Author(s):  
Hidetoshi INO ◽  
Katsuya NAGAI ◽  
Tsutomu FUJIWARA ◽  
Mariko YAMANO ◽  
Shinobu INAGAKI ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Parabrachial Nucleus ◽  
Lateral Part ◽  
Stimulation Of

Hyperglycemia induced by electrical stimulation of lateral part of dorsal parabrachial nucleus

1988 ◽  
Vol 254 (4) ◽  
pp. E468-E475
Author(s):  
T. Fujiwara ◽  
K. Nagai ◽  
S. Takagi ◽  
H. Nakagawa
Keyword(s):  
Electrical Stimulation ◽  
Glucagon Secretion ◽  
Light Period ◽  
Parabrachial Nucleus ◽  
Lateral Part ◽  
Beta Adrenergic ◽  
Adrenergic Mechanism ◽  
Adrenergic Blocker ◽  
Bilateral Lesions ◽  
Stimulation Of

Electrical stimulation of the lateral part of the dorsal parabrachial nucleus (PBD) induces hyperglycemia by enhancing glucagon secretion and suppressing insulin secretion in rats. The mechanism of this effect in the light period was examined by use of blockers of the autonomic nervous system. Hexamethonium, a ganglion blocker, and propranolol, a beta-adrenergic blocker, markedly inhibited the hyperglycemic response to stimulation of the lateral part of the PBD (LPBD). In contrast, phenoxybenzamine, an alpha-adrenergic blocker, and atropine methylnitrate, a muscarinic blocker, had no effect. Because previous studies showed that bilateral lesions of the suprachiasmatic nucleus (SCN) eliminated hyperglycemia induced by intracranial injection of 2-deoxy-D-glucose and that blinding largely suppressed the hyperglycemia, the effects of these two treatments on hyperglycemia induced by electrical stimulation of the LPBD were examined. SCN lesions abolished the hyperglycemic response but did not affect the hyperglucagonemic response. Results 4 wk after orbital enucleation were similar to those after SCN lesions. These findings suggest that the SCN and a beta-adrenergic mechanism are involved in the hyperglycemic response to LPBD stimulation.

Electrical stimulation of the parabrachial nucleus induces reanimation from isoflurane general anesthesia

2016 ◽  
Vol 306 ◽  
pp. 20-25 ◽  
Author(s):  
Fanuel Muindi ◽  
Jonathan D. Kenny ◽  
Norman E. Taylor ◽  
Ken Solt ◽  
Matthew A. Wilson ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
General Anesthesia ◽  
Parabrachial Nucleus ◽  
Stimulation Of

Widespread reductions in cerebral blood flow and metabolism elicited by electrical stimulation of the parabrachial nucleus in rat

1985 ◽  
Vol 341 (2) ◽  
pp. 283-296 ◽  
Author(s):  
Sima Mraovitch ◽  
Costantino Iadecola ◽  
David A. Ruggiero ◽  
Donald J. Reis
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Electrical Stimulation ◽  
Parabrachial Nucleus ◽  
Stimulation Of

Central pathways relaying cardiovascular afferent information to amygdala

1985 ◽  
Vol 248 (1) ◽  
pp. R38-R45 ◽  
Author(s):  
D. F. Cechetto ◽  
F. R. Calaresu
Keyword(s):  
Electrical Stimulation ◽  
Evoked Potentials ◽  
Kainic Acid ◽  
Paraventricular Nucleus ◽  
Firing Frequency ◽  
Parabrachial Nucleus ◽  
Relative Contribution ◽  
Afferent Information ◽  
A Site ◽  
Stimulation Of

It has been suggested that cardiovascular information to the amygdala is relayed through the paraventricular nucleus of the hypothalamus (PVH) and the parabrachial nucleus (PB;7). To test this possibility spontaneously firing units in the amygdala of 12 chloralose-anesthetized cats were monitored for changes in firing frequency during electrical stimulation of PVH and PB and for their responsiveness to baroreceptor (BA) and chemoreceptor (CA) activation. In the ipsilateral amygdala 27 of 140 units responded to PVH stimulation, 9 of which also responded to CA and none to BA, whereas 46 of 150 units responded to PB stimulation, 11 of which also responded to CA and 2 to BA. To demonstrate the relative contribution of the PVH and PB in relaying cardiovascular information to the amygdala, in an additional six cats, the effect of neuronal block and lesions of these two nuclei on potentials evoked in the amygdala by stimulation of the buffer nerves was tested. Reversible neuronal block with injections of procaine in the PB significantly attenuated these evoked potentials. Electrolytic and chemical (kainic acid) lesions in the same PB sites also were effective in attenuating the responses. The potentials were unaltered by injection of procaine in the PVH. These results indicate that the PB is a site of relay of chemoreceptor and of some baroreceptor information from the medulla to the amygdala.

Tooth pulp input to the shell region of nucleus ventralis posteromedialis of the cat thalamus

1986 ◽  
Vol 56 (1) ◽  
pp. 80-98 ◽  
Author(s):  
T. Yokota ◽  
Y. Nishikawa ◽  
N. Koyama
Keyword(s):  
Electrical Stimulation ◽  
Dynamic Range ◽  
Tooth Pulp ◽  
Lateral Part ◽  
Evoked Responses ◽  
Canine Tooth ◽  
Mandibular Canine ◽  
Wdr Neurons ◽  
Shell Region ◽  
Stimulation Of

A population of neurons in the somatosensory part of the nucleus ventralis posteromedialis (VPM proper) that responded to electrical stimulation of the tooth pulp were studied in cats under urethan-chloralose anesthesia. Two classes of units responsive to electrical stimulation of the contralateral canine tooth pulp were identified. One class was responsive only to tooth pulp stimulation and these units were designated as tooth pulp specific (TPS) units. The other class of units responded to mechanical stimulation of the contralateral trigeminal integument in addition to tooth pulp stimulation. Their receptive field characteristics identified them as wide dynamic range (WDR) units responsive to tooth pulp stimulation. Both classes of units were located in the shell region of the caudal VPM proper; TPS units were coexistent with trigeminal nociceptive specific (NS) units and were found in the dorsomedial as well as ventromedial parts of the NS zone. WDR units responsive to electrical stimulation of the tooth pulp were located in the dorsomedial as well as ventromedial parts of WDR zone, a narrow band, approximately 300 micron wide, just in front of the NS zone. Tooth pulp units in the dorsomedial shell region of the VPM proper responded to the maxillary canine tooth pulp, whereas those in the ventromedial shell region responded to the mandibular canine tooth pulp. Some tooth pulp units in these two regions were responsive to stimulation of both maxillary and mandibular canine teeth. Both TPS and WDR units were antidromically excited by electrical stimulation of the SI area of the somatosensory cortex. Cooling the dorsolateral surface of the caudal medulla oblongata reversibly blocked tooth pulp evoked responses of TPS and WDR units. Trigeminal tractotomy just above the level of the obex irreversibly abolished tooth pulp-evoked responses of TPS and WDR units. These findings suggested that TPS neurons in the marginal layer of the trigeminal subnucleus caudalis and WDR neurons in the lateral part of the subnucleus reticularis dorsalis relay afferent impulses derived from the tooth pulp to the shell region of the VPM proper.

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