scholarly journals Abundance of adiponectin system and G-protein coupled receptor GPR109A mRNA in adipose tissue and liver of F2 offspring cows of Charolais × German Holstein crosses that differ in body fat accumulation

2013 ◽  
Vol 96 (1) ◽  
pp. 278-289 ◽  
Author(s):  
M. Mielenz ◽  
B. Kuhla ◽  
H.M. Hammon
Keyword(s):  
Adipose Tissue ◽  
G Protein ◽  
Body Fat ◽  
G Protein Coupled Receptor ◽  
Fat Accumulation ◽  
G Protein Coupled

Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A

2005 ◽  
Vol 334 (2) ◽  
pp. 729-732 ◽  
Author(s):  
Youyan Zhang ◽  
Robert J. Schmidt ◽  
Patricia Foxworthy ◽  
Renee Emkey ◽  
Jennifer K. Oler ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

An atlas of G-protein coupled receptor expression and function in human subcutaneous adipose tissue

2015 ◽  
Vol 146 ◽  
pp. 61-93 ◽  
Author(s):  
Stefan Amisten ◽  
Matt Neville ◽  
Ross Hawkes ◽  
Shanta J. Persaud ◽  
Fredrik Karpe ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
G Protein ◽  
Subcutaneous Adipose Tissue ◽  
Receptor Expression ◽  
G Protein Coupled Receptor ◽  
And Function ◽  
Subcutaneous Adipose ◽  
G Protein Coupled

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

2020 ◽  
Vol 134 (5) ◽  
pp. 473-512 ◽  
Author(s):  
Ryan P. Ceddia ◽  
Sheila Collins
Keyword(s):  
Adipose Tissue ◽  
Energy Expenditure ◽  
Signaling Pathways ◽  
G Protein ◽  
Uncoupling Protein ◽  
Beige Adipocytes ◽  
Nucleotide Regulation ◽  
Ucp1 Expression ◽  
Thermogenic Adipocytes ◽  
G Protein Coupled

Abstract With the ever-increasing burden of obesity and Type 2 diabetes, it is generally acknowledged that there remains a need for developing new therapeutics. One potential mechanism to combat obesity is to raise energy expenditure via increasing the amount of uncoupled respiration from the mitochondria-rich brown and beige adipocytes. With the recent appreciation of thermogenic adipocytes in humans, much effort is being made to elucidate the signaling pathways that regulate the browning of adipose tissue. In this review, we focus on the ligand–receptor signaling pathways that influence the cyclic nucleotides, cAMP and cGMP, in adipocytes. We chose to focus on G-protein–coupled receptor (GPCR), guanylyl cyclase and phosphodiesterase regulation of adipocytes because they are the targets of a large proportion of all currently available therapeutics. Furthermore, there is a large overlap in their signaling pathways, as signaling events that raise cAMP or cGMP generally increase adipocyte lipolysis and cause changes that are commonly referred to as browning: increasing mitochondrial biogenesis, uncoupling protein 1 (UCP1) expression and respiration.

Vanadium compounds cause activation of G protein-coupled receptor signaling

2020 ◽  
Author(s):  
Debbie C. Crans ◽  
Duaa Althumairy ◽  
Heide Murakami ◽  
B. George Barisas ◽  
Deborah Roess
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Vanadium Compounds ◽  
G Protein Coupled
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