Vanadium compounds therapeutic effects in melanoma

Background Polyoxometalates are a diverse family of metal-oxo anions of early transitional metal ions in high oxidation states, including vanadium. Such compounds are gaining increasing interest in biomedicine due to their anti-cancer activity. Regarding melanoma, available therapies’ effectiveness is still currently limited, commonly leading to relapse. For this reason, it is vital to identify novel anti-cancer agents. Methods To better understand the mechanism of action involved in the anti-cancer vanadium-based compounds in melanoma, we conducted a systematic review. Search was performed in Clinical Trials, Cochrane Library, Pubmed, Scielo, and Web of Science (20/4-8/5/2020). Review articles were excluded. Inclusion criteria considered articles between 2000 and 2020, written in English, in which vanadium compounds were evaluated alone (not combined with other drugs), allowing to recognise the effects exclusively derived from vanadium. Results Based on the inclusion/exclusion criteria, a total of 5 articles, published between 2013 and 2020, were analyzed. All tested compounds, including Oxidovanadium(IV) complexes [VIVO(mpp)2] and [VIVO(ppp)2] (VS3, VS4), reduced cellular viability. Moreover, Vanadium pentoxide (V2O5) and Xyloglucan from Copaifera Langsdorffii complexed with Oxovanadium(IV/V) (XGC:VO), in murine B16F10 cells, and Inorganic anion vanadate (VN), [VIVO (dhp)2] (VS2), and N,N’-ethylenebis (pyridoxylideneiminato) vanadium(IV) complex [Pyr2enV(IV)], in A375 cells, induced apoptosis. VN, VS2 and Pyr2enV(IV) increased reactive oxygen species (ROS) levels in A375 cells. In vivo experiments demonstrated that V2O5 prolonged the life of mice implanted with B16F10 cells, with no systemic toxicity. Conclusions Several different vanadium-based compounds have anti-cancer potential in melanoma, mainly increasing apoptosis and ROS production. Specific metal-based complexes are potential melanoma treatments, which might have been previously neglected.

Vanadium and Melanoma: A Systematic Review

The application of metals in biological systems has been a rapidly growing branch of science. Vanadium has been investigated and reported as an anticancer agent. Melanoma is the most aggressive type of skin cancer, the incidence of which has been increasing annually worldwide. It is of paramount importance to identify novel pharmacological agents for melanoma treatment. Herein, a systematic review of publications including “Melanoma and Vanadium” was performed. Nine vanadium articles in several melanoma cells lines such as human A375, human CN-mel and murine B16F10, as well as in vivo studies, are described. Vanadium-based compounds with anticancer activity against melanoma include: (1) oxidovanadium(IV); (2) XMenes; (3) vanadium pentoxide, (4) oxidovanadium(IV) pyridinonate compounds; (5) vanadate; (6) polysaccharides vanadium(IV/V) complexes; (7) mixed-metal binuclear ruthenium(II)–vanadium(IV) complexes; (8) pyridoxal-based oxidovanadium(IV) complexes and (9) functionalized nanoparticles of yttrium vanadate doped with europium. Vanadium compounds and/or vanadium materials show potential anticancer activities that may be used as a useful approach to treat melanoma.

Electronic heat capacity of some vanadium compounds at low temperatures

The paper presents the results of a study of the temperature dependence of molar heat capacity at constant pressure in the range (from 5 to 300 K) for vanadium-based materials. For all the studied materials, the values of the density of States near the Fermi level are calculated. It was found that for V3Si and V3Ge materials, the values of the state density μ( E ) correlate with the transition temperatures to the superconducting state. For materials V2O3 and V1.973Me0.027O3 (Me - Al, Fe, Cr), it was found that the temperatures of metal-dielectric phase transitions decrease with increasing values of the density of States.

Physico-Chemical Foundation of Sludge Processing Hydrometallurgical Production of Vanadium Pentoxide. Investigation of Forms of Vanadium Compounds

To develop the physico-chemical basis of a complex technology for processing slurries hydrometallurgical production of vanadium pentoxide it is necessary to know in what form vanadium compounds are in the dump sludge and at what stage of processing they were formed, which is why vanadium is not completely extracted into the solution. This paper investigates the behavior of vanadium in the existing process chain (with the study of intermediate products of technological conversion) using a set of modern analytical methods (X-ray diffraction, SEM, X-ray diffraction, thermogravimetry). Keywords: vanadium, slag, sludge, vanadium pentoxide, oxidation state, phase composition, processing technology

Vanadium in the environment as a risk factor causing negative modification of cell death (scientific review)

The review dwells on results obtained via examinations that focused on effects produced by vanadium and its compounds contaminating the environment on health disorders related to cell death deregulation. Research works that have been performed over the last decades and focused on revealing the essence of apoptosis mechanism under exposure to technogenic chemicals are truly vital due to this phenomenon having great biological significance within a system of a body trying to adapt to influences exerted by environmental factors. The present work focuses on apoptosis peculiarities under exposure to excess technogenic concentrations of vanadium compounds. Published research works have been analyzed, analysis results are outlined, and a scientific hypothesis has been formulated within the subject matter. We have described an immune-modulating effect produced by vanadium compounds that is able to modify apoptosis events due to changes in cell death modes (apoptosis activation/inhibition) and it provides body adaptation to changing environmental conditions. A range in vanadium concentrations between essential and toxic ones predetermines multi-directional changes in apoptosis induction and completion. Thus, induced apoptosis activation makes for development of autoimmune and immune-proliferative processes; at the same time, cell death inhibition can result in immune deficiency, inflammatory reactions, and neurodegenerative diseases. It was shown that vanadium compounds produced modifying effects on mitochondrial functions regulation, changes in phosphorilation/dephosphorilation ratio in protein products, and imbalance in free radical processes; all this ultimately disrupts a balance between pro- and anti-apoptotic signals in a cell. Monitoring over apoptosis parameters that characterize cell death under exposure to vanadium and its compounds will allow timely detecting risks of pre-nosology state occurrence and prevent damage to health

Vanadium in the environment as a risk factor causing negative modification of cell death (scientific review) UDC: 616-097

The review dwells on results obtained via examinations that focused on effects produced by vanadium and its compounds contaminating the environment on health disorders related to cell death deregulation. Research works that have been performed over the last decades and focused on revealing the essence of apoptosis mechanism under exposure to technogenic chemicals are truly vital due to this phenomenon having great biological significance within a system of a body trying to adapt to influences exerted by environmental factors. The present work focuses on apoptosis peculiarities under exposure to excess technogenic concentrations of vanadium compounds. Published research works have been analyzed, analysis results are outlined, and a scientific hypothesis has been formulated within the subject matter. We have described an immune-modulating effect produced by vanadium compounds that is able to modify apoptosis events due to changes in cell death modes (apoptosis activation/inhibition) and it provides body adaptation to changing environmental conditions. A range in vanadium concentrations between essential and toxic ones predetermines multi-directional changes in apoptosis induction and completion. Thus, induced apoptosis activation makes for development of autoimmune and immune-proliferative processes; at the same time, cell death inhibition can result in immune deficiency, inflammatory reactions, and neurodegenerative diseases. It was shown that vanadium compounds produced modifying effects on mitochondrial functions regulation, changes in phosphorilation/dephosphorilation ratio in protein products, and imbalance in free radical processes; all this ultimately disrupts a balance between pro- and anti-apoptotic signals in a cell. Monitoring over apoptosis parameters that characterize cell death under exposure to vanadium and its compounds will allow timely detecting risks of pre-nosology state occurrence and prevent damage to health.