Risk factors for delayed infections after spinal fusion and instrumentation in patients with scoliosis

2014 ◽  
Vol 21 (4) ◽  
pp. 648-652 ◽  
Author(s):  
Jianxiong Shen ◽  
Jinqian Liang ◽  
Haiquan Yu ◽  
Guixing Qiu ◽  
Xuhong Xue ◽  
...  
Keyword(s):  
Risk Factors ◽  
Surgical Treatment ◽  
Blood Transfusion ◽  
Spinal Fusion ◽  
Predictive Factors ◽  
Operation Time ◽  
Control Group ◽  
Allogenic Blood Transfusion ◽  
Allogenic Blood ◽  
Delayed Infection

Object There are limited published data about the risk factors for the development of delayed infections after spinal fusion and instrumentation in the population with scoliosis. The objective of this study was to evaluate the predictive factors of development of delayed infections in patients with scoliosis who underwent surgical treatment. Methods A total of 17 patients with scoliosis and delayed infections were identified from 3463 patients with scoliosis who received surgical treatment. The control group was composed of 85 patients with scoliosis without infections, matched for sex, age, approximate date of surgery, and diagnosis. These 2 groups were compared for demographic distribution and clinical data to investigate the predictive factors of delayed infections. Results The overall incidence rate of delayed infections was 0.49%. The variables of age, body mass index, and number of levels fused were similar between the 2 groups. The average primary curve magnitude for the delayed infection and control (uninfected) groups was 80.4° ± 27.0° (range 47°–135°) and 66.3° ± 11.6° (range 42°–95°), respectively (p = 0.001). Operation time in the group with delayed infections was 384.7 ± 115.9 minutes versus 254.4 ± 79.2 minutes in the control group (p = 0.000), and estimated blood loss was 1342.2 ± 707.2 ml versus 833.9 ± 235.6 ml (p = 0.000) in these 2 groups, respectively. The perioperative mean red blood cell transfusion requirement in the delayed infection group was significantly higher than that found in patients without infections (2.8 ± 2.3 units/patient versus 1.1 ± 1.6 units/patient, respectively; p = 0.000). Logistic regression analysis showed that operation time and allogenic blood transfusion were the 2 independent predictors of delayed infections (odds ratio [OR] 1.021, 95% confidence interval [CI] 1.010–1.033, and OR 1.546, 95% CI 1.048–2.278, respectively). Conclusions The occurrence of a delayed infection in patients with scoliosis who undergo surgical treatment is most likely multifactorial and is related to surgical time and the use of allogenic blood transfusion.

scholarly journals Efficacy and Safety of Tranexamic Acid in Bimaxillary Orthognathic Surgery

2020 ◽  
Vol 28 (2) ◽  
pp. 94-104
Author(s):  
Liang Sun ◽  
Rui Guo ◽  
Yi Feng
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Orthognathic Surgery ◽  
Operation Time ◽  
Controlled Trials ◽  
Allogenic Blood Transfusion ◽  
Intraoperative Blood Loss ◽  
Irrigation Fluid ◽  
Allogenic Blood

Background: Tranexamic acid (TXA) has been widely used during craniofacial and orthognathic surgery (OS). However, results of the literature are inconsistent due to specific type of surgery and a small sample of studies. The purpose of this study was to evaluate the role of TXA in bimaxillary OS. Methods: We performed a comprehensive literature search of PubMed, Cochrane Central Register of Controlled Trials, and EMBASE to identify randomized controlled trials (RCTs) that compared effect of TXA on bimaxillary OS with placebo. Outcomes of interests included intraoperative blood loss, allogenic transfusion, operation time, and volume of irrigation fluid. Random effects models were chosen considering that heterogeneity between studies was anticipated, and I 2 statistics were used to test for the presence of heterogeneity. Results: Totally 6 RCTs were identified. Tranexamic acid resulted in significantly reduced intraoperative blood loss (weighted mean difference [WMD] = −264.82 mL; 95% CI: −380.60 to −149.04 mL) and decreased amounts of irrigation fluid (WMD = −229.23 mL; 95% CI: −399.63 to −58.83 mL). However, TXA had no remarkable impact on risk of allogenic blood transfusion (pooled risk ratio = 0.50; 95% CI: 0.20-1.23), operation time (WMD = −8.71 min; 95% CI: −20.98 to 3.57 min), and length of hospital stay (WMD = −0.24 day; 95% CI: −0.62 to 0.14 day). No TXA-associated severe adverse reactions or complications were observed. Conclusions: Currently available meta-analysis reveals that TXA is effective in decreasing intraoperative blood loss; however, it does not reduce the risk of allogenic blood transfusion in bimaxillary OS.

scholarly journals The use of tranexamic acid for the prevention of hemorrhagic complications in percutaneous nephrolithotripsy

2021 ◽  
Vol 14 (2) ◽  
pp. 52-57
Author(s):  
S.V. Popov ◽  
◽  
I.N. Orlov ◽  
A.Y. Kulikov ◽  
D.A. Sytnik ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Blood Transfusion ◽  
Tranexamic Acid ◽  
Postoperative Period ◽  
Operation Time ◽  
Patient Treatment ◽  
Control Group ◽  
Irrigation Fluid ◽  
Hemorrhagic Complications ◽  
Percutaneous Nephrolithotripsy

Introduction. The problem of urolithiasis remains relevant throughout the world. The widespread prevalence of the disease is the reason for the search for new and effective methods of dealing with various complications of surgical treatment in order to improve the efficiency of patient treatment. Materials and methods. The material was searched in the following databases: PubMed, Google Scholar, Scopus by keywords such as  Tranexamic acid and percutaneous nephrolithotripsy . When searching in the above databases, 18 articles were found and analyzed. The results of preoperative, intra – and postoperative use of tranexamic acid (TA) in various dosages, and the frequency of the drug use, including the addition of TA to the irrigation fluid, are described. Indicators such as the average level of hemoglobin, the time of surgery, the need for blood transfusion, and the volume of irrigation fluid were evaluated. In all these cases, the control group consisted of patients for whom TA was not used either before the operation or in the postoperative period. Results. The article presents an analysis of the literature data on the correction of hemorrhagic complications by the use of TА. The data on intra- and postoperative hemorrhagic complications of percutaneous nephrolithotripsy (PNLT) and the effect of TА on them are presented. The results of preoperative, intra- and postoperative use of TА in various dosages, and the frequency of use of the drug, including the addition of TА to the irrigation fluid, are described. Indicators such as the average hemoglobin level, operation time, the need for blood transfusion, and the volume of irrigation fluid were assessed. In all the above cases, the control group consisted of patients in whom TА was not used either before the operation or in the postoperative period. Conclusions. The results obtained make it possible to judge the safety and appropriateness of the use of TА in order to reduce the degree of hemorrhagic complications both during the operation and in the postoperative period. Assessment of the hemostatic system and the effect of hemostatic drugs during the surgical treatment of urolithiasis on the upper urinary tract, in our opinion, is a key moment in improving the effectiveness of patient treatment.

Prognostic impact of allogenic blood transfusion following surgical treatment of esophageal cancer

2019 ◽  
Vol 51 (5) ◽  
pp. 246-253
Author(s):  
Dejan Velickovic ◽  
Predrag Sabljak ◽  
Dejan Stojakov ◽  
Jelena Velickovic ◽  
Keramatollah Ebrahimi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Surgical Treatment ◽  
Blood Transfusion ◽  
Allogenic Blood Transfusion ◽  
Prognostic Impact ◽  
Allogenic Blood

Perioperative Allogenic Blood Transfusion in Renal Cell Carcinoma: Risk Factors and Effect on Long-term Outcomes

2017 ◽  
Vol 15 (3) ◽  
pp. e421-e427 ◽  
Author(s):  
Francesco Soria ◽  
Michela de Martino ◽  
Carmen V. Leitner ◽  
Marco Moschini ◽  
Shahrokh F. Shariat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Cell Carcinoma ◽  
Blood Transfusion ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Allogenic Blood Transfusion ◽  
Long Term Outcomes ◽  
Allogenic Blood ◽  
Carcinoma Risk
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