scholarly journals Lucien J. Rubinstein: enduring contributions to neuro-oncology

2005 ◽  
Vol 18 (4) ◽  
pp. 1-11 ◽  
Author(s):  
Melike Mut ◽  
M. Beatriz S. Lopes ◽  
Mark Shaffrey
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Cultures ◽  
Tumor Biology ◽  
Cns Tumors ◽  
Electron Microscopic ◽  
Diagnostic Investigation ◽  
Nervous System Tumors ◽  
Microscopic Features

Dr. Lucien Rubinstein is best remembered for his significant contributions to the field of neuropathology, particularly in the classification of nervous system tumors. His accomplishments in basic neuro-oncology and in the formulation of diagnostic principles reflected a unique talent for synthesizing fundamental clinicopathological concepts based on skillful diagnostic investigation and a thorough understanding of neurobiology. Dr. Rubinstein was the leader in the establishment of cell cultures from central nervous system (CNS) tumors. He meticulously analyzed both light and electron microscopic features of CNS tumors, recorded his findings, and patiently drew sketches to be shared generously with his colleagues and students. As a pioneer in neuropathology, in his work Dr. Rubinstein set the foundation for many enduring concepts in neurosurgery, neuro-oncology, neurology, and basic tumor biology.

scholarly journals Epidemiologic Study of Central Nervous System Tumors in Rwanda

2020 ◽  
pp. 1-14
Author(s):  
David Hakizimana ◽  
Agabe Emmy Nkusi ◽  
David Hakizimana ◽  
Eric Shingiro ◽  
Paulin Munyemana ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumors ◽  
Age Groups ◽  
Epidemiologic Study ◽  
Cns Tumors ◽  
Central Nervous System Tumors ◽  
Secondary Neoplasms ◽  
Nervous System Tumors ◽  
The Central Nervous System

Introduction: Tumors of the central nervous system (CNS) are primary or secondary neoplasms located within the craniovertebral cavity. The incidence of CNS tumors is not uniform with variation between different countries, age groups and races. Objective: Our study aim was to generate new knowledge of the epidemiology of central nervous system tumors in Rwanda. Method: This was an observational retrospective study of all patients diagnosed with CNS tumors in Rwanda over a period of 10 years, from 1st January 2006 to 31st December 2015. Results: 466 patients enrolled, (52.2% females, 47.8% males). The median age at diagnosis of was 37 years. Brain tumors were 82.7%; spine tumor patients were 16.4%. The average annual age-standardized incidence of CNS tumors was 0.43/100, 0000 person-years and varied with age groups. Tumors of meningothelial cells represented the majority of brain tumors (31.8%). Metastatic tumors were the far most common spine tumors category. 55.8 % of CNS tumors reported in our study were histologically confirmed and of nonmalignant meningiomas were the commonest (33.9%). Conclusion: This is the very first study done on epidemiology of CNS tumors in Rwanda, and generated data about incidence of CNS tumors in Rwanda and their location and histological distribution.

Ewing's Family of Tumors Involving Structures Related to the Central Nervous System: A Review

2000 ◽  
Vol 3 (3) ◽  
pp. 203-210 ◽  
Author(s):  
M. Gary Hadfield ◽  
Martha M. Quezado ◽  
Robert L. Williams ◽  
Vivian Y. Luo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Soft Tissues ◽  
Case Reports ◽  
Spinal Column ◽  
Diagnostic Methods ◽  
Electron Microscopic ◽  
Adjacent Structures ◽  
Microscopic Features ◽  
The Central Nervous System

This review consolidates information gleaned from several case reports and larger series on Ewing's sarcoma family of tumors (EFT) involving structures related to and found in the central nervous system (CNS). These tumors involve the skull, the spinal column, adjacent soft tissues, the meninges, and the brain. We have separated the cases by skull region and spinal column level, and we discuss the attendant differences in prognosis following treatment by neurosurgery, radiation, and chemotherapy. Light and electron microscopic features can be used to differentiate EFT from other small round blue cell tumors that involve the CNS (central primitive neuroectodermal tumor, lymphoma, etc.). Recent molecular and genetic findings in EFT provide new diagnostic methods. We conclude that EFT involving the CNS and adjacent structures is not so rare as previously stated and that the prognosis is more favorable, as a rule, than for the more common examples arising in the long bones and pelvis.

scholarly journals Toward methylation-based classification of central nervous system tumors

2018 ◽  
Vol 20 (5) ◽  
pp. 579-581
Author(s):  
Monika E Hegi ◽  
Paul Kleihues ◽  
Patrick Y Wen ◽  
Mario L Suvà
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors

The 2016 WHO classification of primary central nervous system tumors: a clinician's view

2018 ◽  
Vol 82 (3) ◽  
pp. 88 ◽  
Author(s):  
G. L. Kobyakov ◽  
O. V. Absalyamova ◽  
A. A. Poddubskiy ◽  
K. S. Lodygina ◽  
E. A. Kobyakova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Who Classification ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors

Classification of Central Nervous System Tumors – WHO 2016 Update

2017 ◽  
Vol 80/113 (3) ◽  
pp. 353-356
Author(s):  
Jiří Polívka ◽  
Tomáš Řepík ◽  
Luboš Holubec ◽  
Jiří Polívka jr
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors
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