scholarly journals Glomangiomyoma of Uncertain Malignant Potential in the Urinary Bladder: A Case Report

2021 ◽  
Vol 59 (239) ◽  
Author(s):  
Sanat Chalise ◽  
Abhimanyu Jha ◽  
Prakash Raj Neupane
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Subcutaneous Tissue ◽  
Smooth Muscle Actin ◽  
Bladder Tumour ◽  
Malignant Potential ◽  
Glomus Tumour ◽  
Uncertain Malignant Potential ◽  
Ki 67 ◽  
Unusual Variant

Glomus tumour typically occurs in subcutaneous tissue but rarely in the visceral organs. Most glomus tumours are benign but few atypical glomus tumours have been reported. Herein, we report a case of a 44-year-old male who presented with hematuria. Transurethral resection of bladder tumour was done. Microscopic examination showed nests and sheets of tumor around the blood vessels. Spindle cells resembling smooth muscle were also observed. An increase in mitosis was observed. These tumour cells show diffuse and strong cytoplasmic positivity for smooth muscle actin and negative for Pancytokeratin, Desmin, Synaptophysin, Chromogranin, S100, and Cluster of Differentiation 34. Ki-67 index was approximately 5%. To our knowledge, this is the first report of Glomangiomyoma of uncertain malignant potential in the urinary bladder which is considered as an unusual variant of atypical glomus tumor. This case emphasizes the importance of broad differential diagnosis which has to be considered in the urinary bladder mass.

scholarly journals Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMP): A Retrospective Study in A Single Center

2021 ◽  
Author(s):  
Chen Zhang ◽  
Juan Gao ◽  
Shanshan Lu ◽  
Yinli Zhang ◽  
Honglan Zhu
Keyword(s):  
Smooth Muscle ◽  
Biological Diversity ◽  
Recurrence Risk ◽  
Malignant Potential ◽  
Diagnostic Methods ◽  
Uncertain Malignant Potential ◽  
Ki 67 ◽  
Uterine Smooth Muscle ◽  
Fertility Sparing ◽  
Smooth Muscle Tumors

Abstract Purpose: Uterine smooth muscle tumors of uncertain malignant potential (STUMP) is a heterogeneous group of tumors with histological and biological diversity that cannot be defined as a benign leiomyoma or malignant leiomyosarcoma. The study aims to investigate the diagnostic methods, treatment management and prognosis of STUMP patients in a 13-year period. Methods: We retrospectively reviewed the clinicopathologic information of 31 STUMP patients in Peking University People’s Hospital. Statistical analyses were conducted to compare the difference of clinical characteristics between the women in myomectomy group and those in hysterectomy group. Results: The most common clinical presentation was menstrual disorder. The tumors were mainly manifested as hypoechoic, non-cystic nodules with low blood flow signal by pelvic doppler ultrasonography. Most tumors carried Ki-67 index ranging from 10% to 30%. Immunohistochemical markers such as ER, PR, p16 and Desmin was positively expressed in tumors. At the first operation, 21 cases underwent myomectomy and 10 cases underwent hysterectomy. The patients in myomectomy group were younger than those in hysterectomy group. In the follow-up period, two cases experienced a relapse in the form of STUMP within 36 months. One case died of cardiovascular accident while the other cases were alive. Six of 21 women in myomectomy group desired pregnancy and two healthy live births were recorded.Conclusion: The diagnosis of STUMP primarily depends on histopathologic features. Fertility-sparing surgery may be a treatment selection for patients with fertility desire. Patients with STUMP, especially in the case of myomectomy, should be informed of recurrence risk and monitored closely.

Smooth Muscle Tumor of Uncertain Malignant Potential of the Urinary Bladder: A Case Report and Review of the Literature

2013 ◽  
Vol 11 (4) ◽  
pp. e6-e9 ◽  
Author(s):  
Ziv Zukerman ◽  
Riccardo Schiavina ◽  
Marco Borghesi ◽  
Eugenio Brunocilla ◽  
Valerio Vagnoni ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Urinary Bladder ◽  
Smooth Muscle Tumor ◽  
Malignant Potential ◽  
Review Of The Literature ◽  
Uncertain Malignant Potential ◽  
Muscle Tumor

scholarly journals Clinical and reproductive outcomes of uterine smooth muscle tumor of uncertain malignant potential: a single-center retrospective study

2021 ◽  
Vol 49 (4) ◽  
pp. 030006052110080
Author(s):  
Chengcheng Ning ◽  
Lihong Zhang ◽  
Chenyan Zhao ◽  
Xiaojun Chen ◽  
Xiaoxia Liu ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Young Patients ◽  
Smooth Muscle Tumor ◽  
Malignant Potential ◽  
Single Center ◽  
Uncertain Malignant Potential ◽  
Ki 67 ◽  
Uterine Smooth Muscle ◽  
Pathological Review ◽  
Muscle Tumor

Objective To evaluate the clinical outcomes, histopathological features, and obstetric and oncological outcomes of uterine smooth muscle tumor of uncertain malignant potential (STUMP). Methods We conducted a single-center, database review of patients with STUMP between January 2001 and December 2015. We investigated the clinical, operative, histopathologic, recurrence, and fertility outcomes of the included cases. Results Nineteen patients with STUMP were studied. Three were reclassified as sarcoma after slide review, and 16 patients were finally included in the study. The mean age was 45 years. Ki-67 expression was ≥10% in 25.0% of cases and 30% in the only recurrent case. Recurrence occurred 52 months after a diagnosis of STUMP in a 56-year-old female patient who underwent hysterectomy. Two of six patients who underwent myomectomy had fertility requirements, and both successfully delivered babies without recurrence. Recurrence was not related to mitosis, degree of atypia, or necrosis. There was also no relationship between type of surgery or surgical approach and recurrence. Conclusions Patients with STUMP warrant a pathological review process in centers with experience. Fertility-preservation is worth attempting, but young patients must be followed-up closely. Ki-67 might be a valuable marker predicting recurrence.

Stanford parameters stratify the risk of recurrence in gynecologic smooth muscle tumors of uncertain malignant potential (STUMP)

Apmis ◽  
2021 ◽  
Author(s):  
Antonio Travaglino ◽  
Antonio Raffone ◽  
Annarita Gencarelli ◽  
Carola Caldarelli ◽  
Marcello Granata ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Malignant Potential ◽  
Uncertain Malignant Potential ◽  
Risk Of Recurrence ◽  
Smooth Muscle Tumors

Unusual morphological features of uterine leiomyomas treated with progestogens

2011 ◽  
Vol 64 (6) ◽  
pp. 485-489 ◽  
Author(s):  
Clinton Boyd ◽  
W Glenn McCluggage
Keyword(s):  
Smooth Muscle ◽  
Mitotic Activity ◽  
Intrauterine Device ◽  
Malignant Potential ◽  
Morphological Features ◽  
Uterine Leiomyomas ◽  
Pathological Features ◽  
Uncertain Malignant Potential ◽  
Smooth Muscle Tumour ◽  
Benign Leiomyoma

BackgroundUterine leiomyomas are extremely common in surgical pathology practice and in the vast majority there are no issues in diagnosis. Progestogens are widely prescribed drugs for a variety of indications, including abnormal uterine bleeding, and are often given to women with leiomyomas but the pathological features of leiomyomas treated with progestogens are poorly described.MethodsWe report the pathological features in eight cases of uterine leiomyomas in women who had been treated with oral progestogens or a progestogen-containing intrauterine device; all cases were received in consultation because the features raised concern for leiomyosarcoma, smooth muscle tumour of uncertain malignant potential or a benign leiomyoma with unusual features. Additionally, we reviewed a series of cases of uterine leiomyomas (n=99) in women who exhibited progestogenic effects in the endometrium.ResultsThe morphological features in the consult cases, which were widespread and marked and which varied somewhat from case to case, included small and/or large areas of infarct-type necrosis (sometimes mimicking coagulative tumour cell necrosis) with surrounding increased cellularity, mitotic activity, nuclear pyknosis, cytoplasmic eosinophilia, epithelioid morphology, stromal oedema, haemorrhage, and myxoid change and infiltration by CD56 positive granulated lymphocytes. Sometimes the features resulted in an almost deciduoid appearance. Similar features were present to a minor degree in significant numbers of the additional series of cases.ConclusionsPathologists should be aware of these progestogen-associated features when reporting uterine leiomyomas whether or not the clinician has indicated that the woman is taking progestogens since otherwise a diagnosis of leiomyosarcoma or smooth muscle tumour of uncertain malignant potential may be rendered. Useful features in suggesting a benign leiomyoma, in addition to recognition of the morphological features described which, in combination, are characteristic of progestogens, are the lack of true nuclear atypia and the low mitotic activity away from the abnormal areas.

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