Predicting the Prognosis of Oral Tongue Carcinoma Using a Simple Quantitative Measurement Based on Preoperative MR Imaging: Tumor Thickness versus Tumor Volume

Background: Carcinoma of oral tongue is the most common oral cancer and because of its structure and function is prone for early local and regional spread of cancer. The final outcome of a primary tongue carcinoma patient depends upon various prognostic factors like thickness of tumor, depth of invasion, size of lesion and neck node 67metastasis. Risk of metastasis and spread to neck nodes increases with increase in tumor thickness Methods: This prospective observational study was carried out in the Department of Otolayngology- Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka for 18 months. Thirty patients with early oral tongue carcinoma i.e.T1 & T2 as per UICC and AJC criteria were included in this study by purposive non-randomized sampling technique. Result of the study were expressed as mean, standard deviation (+SD), frequency and percentages. Unpaired Student’s t-test and Pearson’s correlation co-efficient (r) test were performed. Results: Result of the study showed the mean (+SD) thickness of the tumor was 3.62 (+1.46) mm. Minimum thickness 1.1mm and maximum thickness 7.8mm. Only 21 (70%) subjects neck node were metastasized from tongue and mean (+SD) tumor thickness of the positive neck node metastasis was 5.54 (+1.07) mm and negative neck node metastasis was 2.87 (+0.75) mm. This indicated a significant difference between the groups. Pearson’s correlation co-efficient r (+0.981) which indicated tumor thickness was positively correlated with neck node metastasis. Conclusion: Tumor thickness of the early oral carcinoma positively correlated with neck node metastasis. Correlation between thickness and metastatic lymph node can help planning the treatment regimen and indicate the disease prognosis. Bangladesh J Otorhinolaryngol; April 2021; 27(1): 25-35

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Preoperative measurement of tumor thickness of oral tongue carcinoma with intraoral ultrasonography

Head & Neck ◽

10.1002/hed.20678 ◽

2008 ◽

Vol 30 (2) ◽

pp. 230-234 ◽

Cited By ~ 40

Author(s):

Anthony Po-Wing Yuen ◽

Raymond Wai-Man Ng ◽

Paul Kin-Yip Lam ◽

Ambrose Ho

Keyword(s):

Tumor Thickness ◽

Tongue Carcinoma ◽

Oral Tongue

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Preoperative measurement of tumor thickness of oral tongue carcinoma with intraoral ultrasonography

Yearbook of Otolaryngology-Head and Neck Surgery ◽

10.1016/s1041-892x(09)79438-7 ◽

2009 ◽

Vol 2009 ◽

pp. 17

Author(s):

M. Gapany

Keyword(s):

Tumor Thickness ◽

Tongue Carcinoma ◽

Oral Tongue

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Qualitative and Quantitative Measurement of Brain Activity Associated with Visual Sexual Arousal in Males and Females: 3.0 Tesla Functional MR Imaging

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2004.51.2.179 ◽

2004 ◽

Vol 51 (2) ◽

pp. 179 ◽

Cited By ~ 4

Author(s):

Hyung Joong Kim ◽

Gwang Woo Jeong ◽

Sung Jong Eun ◽

Seong Hoon Cho ◽

Jeong Jin Seo ◽

...

Keyword(s):

Mr Imaging ◽

Sexual Arousal ◽

Quantitative Measurement ◽

Brain Activity ◽

3.0 Tesla ◽

Qualitative And Quantitative ◽

Functional Mr Imaging ◽

Males And Females

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Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases

Journal of Neurosurgery ◽

10.3171/sup.2005.102.s_supplement.0087 ◽

2005 ◽

Vol 102 (Special_Supplement) ◽

pp. 87-97 ◽

Cited By ~ 19

Author(s):

Wen-Yuh Chung ◽

Kang-Du Liu ◽

Cheng-Ying Shiau ◽

Hsiu-Mei Wu ◽

Ling-Wei Wang ◽

...

Keyword(s):

Mr Imaging ◽

Gamma Knife ◽

Vestibular Schwannoma ◽

Tumor Volume ◽

Radiation Effect ◽

Gamma Knife Surgery ◽

Homogeneous Distribution ◽

Content Type ◽

Fine Print

Object. The authors conducted a study to determine the optimal radiation dose for vestibular schwannoma (VS) and to examine the histopathology in cases of treatment failure for better understanding of the effects of irradiation. Methods. A retrospective study was performed of 195 patients with VS; there were 113 female and 82 male patients whose mean age was 51 years (range 11–82 years). Seventy-two patients (37%) had undergone partial or total excision of their tumor prior to gamma knife surgery (GKS). The mean tumor volume was 4.1 cm3 (range 0.04–23.1 cm3). Multiisocenter dose planning placed a prescription dose of 11 to 18.2 Gy on the 50 to 94% isodose located at the tumor margin. Clinical and magnetic resonance (MR) imaging follow-up evaluations were performed every 6 months. A loss of central enhancement was demonstrated on MR imaging in 69.5% of the patients. At the latest MR imaging assessment decreased or stable tumor volume was demonstrated in 93.6% of the patients. During a median follow-up period of 31 months resection was avoided in 96.8% of cases. Uncontrolled tumor swelling was noted in five patients at 3.5, 17, 24, 33, and 62 months after GKS, respectively. Twelve of 20 patients retained serviceable hearing. Two patients experienced a temporary facial palsy. Two patients developed a new trigeminal neuralgia. There was no treatment-related death. Histopathological examination of specimens in three cases (one at 62 months after GKS) revealed a long-lasting radiation effect on vessels inside the tumor. Conclusions. Radiosurgery had a long-term radiation effect on VSs for up to 5 years. A margin 12-Gy dose with homogeneous distribution is effective in preventing tumor progression, while posing no serious threat to normal cranial nerve function.

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