scholarly journals Relationship between Thickness of Early Oral Tongue Carcinoma (T1, T2) with Cervical Lymph Node Metastasis

2021 ◽  
Vol 27 (1) ◽  
pp. 25-35
Author(s):  
Md Abdur Razzak ◽  
Belayat Hossain Siddique ◽  
Azharul Islam ◽  
Md Hasanul Haque ◽  
Md Abdus Sattar ◽  
...  
Keyword(s):  
Lymph Node ◽  
Tumor Thickness ◽  
Tongue Carcinoma ◽  
Oral Tongue ◽  
Neck Node ◽  
Pearson’S Correlation ◽  
Node Metastasis ◽  
Neck Node Metastasis ◽  
Significant Difference ◽  
Pearson's Correlation

Background: Carcinoma of oral tongue is the most common oral cancer and because of its structure and function is prone for early local and regional spread of cancer. The final outcome of a primary tongue carcinoma patient depends upon various prognostic factors like thickness of tumor, depth of invasion, size of lesion and neck node 67metastasis. Risk of metastasis and spread to neck nodes increases with increase in tumor thickness Methods: This prospective observational study was carried out in the Department of Otolayngology- Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka for 18 months. Thirty patients with early oral tongue carcinoma i.e.T1 & T2 as per UICC and AJC criteria were included in this study by purposive non-randomized sampling technique. Result of the study were expressed as mean, standard deviation (+SD), frequency and percentages. Unpaired Student’s t-test and Pearson’s correlation co-efficient (r) test were performed. Results: Result of the study showed the mean (+SD) thickness of the tumor was 3.62 (+1.46) mm. Minimum thickness 1.1mm and maximum thickness 7.8mm. Only 21 (70%) subjects neck node were metastasized from tongue and mean (+SD) tumor thickness of the positive neck node metastasis was 5.54 (+1.07) mm and negative neck node metastasis was 2.87 (+0.75) mm. This indicated a significant difference between the groups. Pearson’s correlation co-efficient r (+0.981) which indicated tumor thickness was positively correlated with neck node metastasis. Conclusion: Tumor thickness of the early oral carcinoma positively correlated with neck node metastasis. Correlation between thickness and metastatic lymph node can help planning the treatment regimen and indicate the disease prognosis. Bangladesh J Otorhinolaryngol; April 2021; 27(1): 25-35

scholarly journals Clinicopathological Correlation between Depth of Tumor and Neck Node Metastasis in Oral (Tongue and Buccal Mucosa) Carcinoma

2021 ◽  
Vol 12 (1) ◽  
pp. 6-10
Author(s):  
Anuj H Shah ◽  
Rupa P Parikh
Keyword(s):  
Buccal Mucosa ◽  
Tumor Invasion ◽  
Prognostic Indicator ◽  
Nodal Metastasis ◽  
Depth Of Invasion ◽  
Clinicopathological Correlation ◽  
Oral Tongue ◽  
Neck Node ◽  
Node Metastasis ◽  
Neck Node Metastasis

ABSTRACT Aims and objectives (1) To study the depth of tumor invasion in an oral (tongue and buccal mucosa) carcinoma and its correlation with neck metastasis. (2) To know whether the increase in depth of tumor (depth of invasion) increases the chances of cervical nodal metastasis in the oral tongue and buccal mucosa carcinoma and derive cutoff value of depth of invasion at which the metastasis occurs. Materials and methods The study was carried out on 14 tongue and 22 buccal mucosa cases to know the correlation between the depth of tumor and neck node metastasis in the oral (tongue and buccal mucosa) carcinoma. Results Among 36 cases, 10 cases were pN+. Out of 10 cases, 7 (70%) were having depth ≥12 mm and 30% cases (pN+) having depth between 8 and <10. We found it statistically significant and so as the depth of tumor increases the chances of nodal metastasis increases. We found the cutoff for a depth of invasion in both tongue and buccal mucosa carcinomas as 8 out of 22 patients had DOI >10 mm and among them 4 were pN+ and among 14 tongue cases, 3 cases had DOI >8 mm and all of them were pN+. Conclusion For tongue 8 mm and for buccal mucosa, 10 mm of the depth of tumor invasion was calculated as the cutoff depth, above which the incidence of nodal metastasis increases to 75% and 66.66%, respectively. Clinical significance Depth of tumor is an important prognostic indicator in the tongue and buccal mucosa carcinoma to know the cervical nodal metastasis. Hence for an increase in depth of tumor cases, neck must be addressed along with primary tumor excision. Radiological investigations [ultrasonography (USG), magnetic resonance imaging (MRI), computed tomography (CT) scan] play an important role in nodal metastasis detection hence should be considered in carcinoma of the oral tongue and buccal mucosa especially in clinically N0 neck. How to cite this article Shah AH, Parikh RP. Clinicopathological Correlation between Depth of Tumor and Neck Node Metastasis in Oral (Tongue and Buccal Mucosa) Carcinoma. Int J Head Neck Surg 2021;12(1):6–10.

Tumour thickness as a predictor of neck node metastasis at presentation in early T stage squamous cell carcinoma of oral tongue

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 15518-15518
Author(s):  
A. Jamshed ◽  
R. Hussain ◽  
M. Azam ◽  
S. Hameed ◽  
M. A. Shah ◽  
...  
Keyword(s):  
Nodal Metastasis ◽  
Oral Tongue ◽  
Neck Node ◽  
Tumour Thickness ◽  
Node Metastasis ◽  
T Stage ◽  
Neck Node Metastasis ◽  
Group I ◽  
Group Ii ◽  
Neck Nodal Metastasis

15518 Background: Pakistan has one of the highest incidence of oral cancer in the world. Twenty to thirty percent of the patients have occult neck nodal metastasis at presentation. Elective treatment of neck in early T stage tongue cancer is controversial. The study was conducted to determine the risk of neck node metastasis in patients with T1 or T2 carcinoma tongue on the basis of pathological tumour thickness. Methods: The study group consisted of 20 patients with early T stage carcinoma oral tongue treated at Shaukat Khanum Memorial Hospital and Research Centre between December 2003 - October 2005. There were 10 males and 10 female patients. The median age for the group was 54 years. All patients underwent partial glossectomy with modified neck dissection. Histopathological reports were analysed to stage the patients according to AJCC 2002 system. The glossectomy specimen were serially sectioned to determine histological thickness. Nine patients (45%) had pT1 and 11 patients (55%) had pT2 disease. Patients were divided in to three groups based on tumour thickness; Group I (tumor < or = 3 mm), Group II (> 3 mm but < or = 9 mm) and Group III (> 9 mm). Results: In patients with pT1 lesions there were 2, 3 and 4 patients in group I, II and III respectively. Pathological neck nodal metastasis were seen in 0/2 patients in group I, 1/3 patients in group II and 1/4 in group III. With pT2 lesions there were 0, 4 and 7 patients in group I, II and III respectively. Neck nodal metastasis were found in 3/4 and 3/7 in group II and III patients. The risk of neck node metastasis in patients with tumor thickness more than 3 mm was 28% (2/7 patients) for pT1 patients and 55% (6/11 patients) for patients with pT2 disease. Conclusions: Tumor thickness more than 3 mm in patients with early T stage squamous cell carcinoma oral tongue carries a high risk of neck nodal metastasis. Elective neck treatment should be considered for this group of patients. No significant financial relationships to disclose.

A clinical analysis of retropharyngeal lymph node metastasis from oral tongue carcinoma

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Tian-Run Liu ◽  
◽  
Wang Wei ◽  
ShiMin Zhuang ◽  
Liang-En Xie ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Clinical Analysis ◽  
Tongue Carcinoma ◽  
Oral Tongue ◽  
Retropharyngeal Lymph Node ◽  
Node Metastasis

Neck node metastasis after successful brachytherapy for early stage tongue carcinoma

2003 ◽  
Vol 68 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Tsuneaki Nakagawa ◽  
Hitoshi Shibuya ◽  
Ryoichi Yoshimura ◽  
Masahiko Miura ◽  
Norihiko Okada ◽  
...  
Keyword(s):  
Early Stage ◽  
Tongue Carcinoma ◽  
Neck Node ◽  
Node Metastasis ◽  
Neck Node Metastasis

scholarly journals The Effects of Tumor Size, Degree of Differentiation, and Depth of Invasion on the risk of Neck Node Metastasis in Squamous Cell carcinoma of the Oral Cavity

2012 ◽  
Vol 91 (3) ◽  
pp. 130-135 ◽  
Author(s):  
Mehmet Haksever ◽  
Hasan Mete İnançlí ◽  
Ümit Tunçel ◽  
Şefik Sinan Kürkçüoğlu ◽  
Melek Uyar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Size ◽  
Depth Of Invasion ◽  
Neck Node ◽  
Node Metastasis ◽  
Neck Node Metastasis ◽  
Degree Of Differentiation

Cervical lymph node metastasis is the most important prognostic factor in patients with head and neck carcinoma. We retrospectively analyzed the effects of three different variables—tumor size, degree of differentiation, and depth of invasion—on the risk of neck node metastasis in 50 adults who had been treated with surgery for primary squamous cell carcinoma of the oral cavity. Primary tumor depth and other pathologic features were determined by reviewing the pathology specimens. Preoperatively, 36 of the 50 patients were clinically N0; however, occult lymph node metastasis was found in 13 of these patients (36.1%). The prevalence of neck node metastasis in patients with T1/T2 and T3/T4 category tumors was 51.5 and 58.8%, respectively. The associations between the prevalence of neck node metastasis and both the degree of differentiation and the depth of invasion were statistically significant, but there was no significant association between neck node metastasis and tumor size. We conclude that the prevalence of neck lymph node metastasis inpatients with squamous cell carcinoma of the oral cavity increases as the tumor depth increases and as the degree of tumor differentiation decreases from well to poor, as has been shown in previous studies. It is interesting that tumor size, which is the most important component of the TNM system, was not significantly associated with neck node involvement.

scholarly journals Post - Laryngectomy Neck Node Metastasis

2016 ◽  
Vol 9 (3) ◽  
Author(s):  
Kashif Iqbal Malik ◽  
Ghulam Mustafa Arain ◽  
Zubair Iqbal Bhutta
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Total Laryngectomy ◽  
Neck Node ◽  
Node Metastasis ◽  
Neck Node Metastasis ◽  
Smoking Duration ◽  
Neck Recurrence ◽  
Degree Of Differentiation ◽  
Level 2

Neck recurrence after total Laryngectomy in 45 patients was studied with the reference to risk factors & efficacy of surgical treatment for the control of disease. Age, smoking, duration and progression of symptoms, degree of differentiation, site and size of primary tumor were the parameters that affected the lymph node metastasis. In all the patient recurrence was at level 2 and 3. Surgery was found to be the best treatment modality for such recurrence

scholarly journals Relationship of Tumor Thickness with Neck Node Metastasis in Buccal Squamous Cell Carcinoma: An Experience at a Tertiary Care Hospital

2017 ◽  
Vol 21 (03) ◽  
pp. 265-269 ◽  
Author(s):  
Sadaf Ahmed ◽  
Montasir Junaid ◽  
Sohail Awan ◽  
Moaz Choudhary ◽  
Maliha Kazi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Nodal Metastasis ◽  
Tumor Thickness ◽  
Neck Node ◽  
Node Metastasis ◽  
Neck Node Metastasis ◽  
Buccal Squamous Cell Carcinoma

Introduction Squamous cell carcinoma is the most common malignancy of the head and neck, with the buccal mucosa being the most common site involved. Early locoregional metastasis is a hallmark of this disease, and early stage tumors may harbor metastatic nodes that are occult. Certain parameters can help identify high-risk patients for whom the pattern of occult nodal metastasis can be predicted. Tumor thickness is one such objective parameter. Objective To determine the relationship of tumor thickness with neck node metastasis in squamous cell carcinoma of the buccal mucosa. Methods A retrospective chart review of 102 patients with biopsy-proven squamous cell carcinoma of the buccal mucosa with N0 Necks was performed. All patients underwent tumor resection with neck dissection, and the tumor thickness was measured. Univariate and multivariate analyses were performed. Results A total of 102 patients, of which 73.53% were males and 26.47% were females. The mean age of the patients was 49.3 ± 11.1 years. It was found that the risk of neck node metastasis in buccal squamous cell carcinoma increases 35.5 times for a tumor thickness ≥ 2 mm, and the risk of neck node metastasis in buccal squamous cell carcinoma decreases by 0.58 times for each centimeter decrease in tumor size, while the rate of occult neck lymph node metastasis was found to be 37%. Conclusion We conclude that tumor thickness is significantly related with neck nodal metastasis in buccal squamous cell carcinoma, considering the age of the patient and the size of the tumor.

scholarly journals Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective Study

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 548
Author(s):  
Masahiro Kagabu ◽  
Takayuki Nagasawa ◽  
Shunsuke Tatsuki ◽  
Yasuko Fukagawa ◽  
Hidetoshi Tomabechi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Lymph Node Metastasis ◽  
Radical Hysterectomy ◽  
Concurrent Chemoradiotherapy ◽  
Postoperative Adjuvant Chemotherapy ◽  
Node Metastasis ◽  
Significant Difference ◽  
Advanced Stages

Background and Objectives: In October 2018, the International Federation of Gynecology and Obstetrics (FIGO) revised its classification of advanced stages of cervical cancer. The main points of the classification are as follows: stage IIIC is newly established; pelvic lymph node metastasis is stage IIIC1; and para-aortic lymph node metastasis is stage IIIC2. Currently, in Japan, radical hysterectomy is performed in advanced stages IA2 to IIB of FIGO2014, and concurrent chemoradiotherapy (CCRT) is recommended for patients with positive lymph nodes. However, the efficacy of CCRT is not always satisfactory. The aim of this study was to compare postoperative adjuvant chemotherapy (CT) and postoperative CCRT in stage IIIC1 patients. Materials and Methods: Of the 40 patients who had undergone a radical hysterectomy at Iwate Medical University between January 2011 and December 2016 and were pathologically diagnosed as having positive pelvic lymph nodes, 21 patients in the adjuvant CT group and 19 patients in the postoperative CCRT group were compared. Results: The 5 year survival rates were 77.9% in the CT group and 74.7% in the CCRT group, with no significant difference. There was no significant difference in overall survival or progression-free survival between the two groups. There was no significant difference between CT and CCRT in postoperative adjuvant therapy in the new classification IIIC1 stage. Conclusions: The results of the prospective Japanese Gynecologic Oncology Group (JGOG) 1082 study are pending, but the present results suggest that CT may be a treatment option in rural areas where radiotherapy facilities are limited.

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