COVID-19 Is an Independent Risk Factor for Acute Ischemic Stroke

Aim and purpose: Progressive stroke (PS) lacks effective treatment measures and leads to serious disability or death. Retinol binding protein 4 (RBP4) could be closely associated with acute ischemic stroke(AIS). We aimed to explore plasma RBP4 as a biomarker for detecting the progression in patients with AIS. Methods: Participants of this retrospective study were 234 patients with AIS within the 48 h onset of disease. The primary endpoint was to ascertain if there was PS through the National Institute of Health stroke scale (NIHSS), early prognosis was confirmed through the modified Rankin scale score (mRS) at discharge or 14 days after the onset of stroke, and determine the significance of demographic characteristics and clinical data . Results: In this study, 43 of 234 patients demonstrated PS. . The level of plasma RBP4 in patients with progressive stroke was significantly lower (29 mg/L, 22.60－40.38 mg/L) than that without progression (38.70 mg/L, 27.28－46.40 mg/L, P = 0.003). In patients with lower plasma RBP4, he proportion of patients with progression (c2 = 9.63, P = 0.008) and with mRS scores ≥2 (c2 = 6.73, P = 0.035) were significantly higher Multivariate logistic regression analysis showed that a lower RBP4 level on admission was an independent risk factor for progressive stroke during hospitalization with an OR value of 2.70 (P = 0.03, 95% CI: 1.12－6.52). Conclusion: A low plasma RBP4 level on admission could be an independent risk factor of PS during hospitalization.

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Obesity is an independent risk factor for pneumonia in patients admitted with acute ischemic stroke

Atherosclerosis ◽

10.1016/j.atherosclerosis.2018.06.209 ◽

2018 ◽

Vol 275 ◽

pp. e75

Author(s):

M. Papagianni ◽

K. Tziomalos ◽

S. Kostaki ◽

S. Angelopoulou ◽

K. Christou ◽

...

Keyword(s):

Risk Factor ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Independent Risk Factor

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Insulin resistance is an independent risk factor for early neurological deterioration in non-diabetic patients with acute ischemic stroke

Neurological Sciences ◽

10.1007/s10072-019-04221-7 ◽

2020 ◽

Vol 41 (6) ◽

pp. 1467-1473

Author(s):

Donghua Mi ◽

Yilong Wang ◽

Yongjun Wang ◽

Liping Liu

Keyword(s):

Insulin Resistance ◽

Risk Factor ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Independent Risk Factor ◽

Neurological Deterioration ◽

Diabetic Patients ◽

Early Neurological Deterioration

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Study of Serum Uric Acid Level as an Independent Risk Factor in Acute Ischemic Stroke

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2020/95 ◽

2020 ◽

Vol 7 (9) ◽

pp. 442-445

Author(s):

Chandrashekhar K ◽

Mohammed Anwar Hussain ◽

Ishwar S. Hasabi ◽

Suryakanth Suryakanth ◽

Chethan K. Ganteppanavar

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Independent Risk Factor ◽

Serum Uric Acid Level

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Apolipoproteins A1 and B and their ratio in acute ischemic stroke patients with intracranial and extracranial arterial stenosis: an Egyptian study

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-020-00245-5 ◽

2020 ◽

Vol 56 (1) ◽

Author(s):

Ebtesam Mohammed Fahmy ◽

Mohammed Ahmed El Sayed El Awady ◽

Sahar Abdel-Atty Sharaf ◽

Nora Mahmoud Selim ◽

Hazem El Sawy Abdo ◽

...

Keyword(s):

Risk Factor ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Independent Risk Factor ◽

Ldl Cholesterol ◽

Arterial Stenosis ◽

Intracranial Arterial Stenosis ◽

Apo B ◽

Significant Difference ◽

Extracranial Stenosis

Abstract Background Apolipoprotein A1 and B and their ratio are considered a better biomarker for cardiovascular diseases than a lipid profile, but this previous finding is not proved to cerebrovascular ischemic diseases. The aim of this study is to assess the relation between apolipoprotien A1 and B and their ratio to intra- and extracranial carotid atherosclerosis in patients with ischemic acute stroke. Methods 90 Egyptian patients with acute ischemic stroke are included in the study, and they have been classified into 3 groups: group 1 includes 30 patients with intracranial stenosis, group 2 includes 30 patients with extracranial arterial stenosis, and group 3 includes 30 patients with non-arterial stenosis. Patients were subjected to clinical assessment, routine laboratory measures, and Color-Coded Duplex Sonography for extracranial and intracranial arteries. The measurement of serum levels of apolipoproteins A1 and B was done using enzyme-linked immuno-sorbent assay (ELISA). Results A statistically significant difference was found between patient groups as regards the frequency of abnormal serum LDL-cholesterol (p = 0.04), being elevated in patients with extracranial stenosis (p = 0.01). There was a significant difference between patients groups as regards the frequency of abnormal serum HDL-cholesterol (p = 0.02), being lower in patients with extracranial stenosis. High Apo B/A1 ratio was an independent risk factor for intracranial arterial stenosis (p = 0.045). An abnormal elevation of serum LDL cholesterol was an independent risk factor of extracranial arterial stenosis (p = 0.021). Conclusion Apo B/A1 ratio is an independent risk factor for intracranial arterial stenosis, while serum LDL cholesterol is an independent risk factor for extracranial arterial stenosis. Apo B/A1 ratio and serum LDL cholesterol are reliable serum biomarkers for cranial arterial stenosis in acute ischemic stroke patients.

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Stroke-Associated Infection Is an Independent Risk Factor for Poor Outcome after Acute Ischemic Stroke: Data from the Netherlands Stroke Survey

Cerebrovascular Diseases ◽

10.1159/000210093 ◽

2009 ◽

Vol 27 (5) ◽

pp. 465-471 ◽

Cited By ~ 130

Author(s):

Frederique H. Vermeij ◽

Wilma J.M. Scholte op Reimer ◽

Peter de Man ◽

Robert J. van Oostenbrugge ◽

Cees L. Franke ◽

...

Keyword(s):

Risk Factor ◽

Ischemic Stroke ◽

The Netherlands ◽

Acute Ischemic Stroke ◽

Independent Risk Factor ◽

Poor Outcome

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Association of H-Type Hypertension with Stroke Severity and Prognosis

BioMed Research International ◽

10.1155/2018/8725908 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Tan Li ◽

Jiajia Zhu ◽

Qi Fang ◽

Xiaoyu Duan ◽

Mingzhi Zhang ◽

...

Keyword(s):

Risk Factor ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Independent Risk Factor ◽

Cox Regression ◽

Stroke Recurrence ◽

Control Group ◽

Stroke Severity ◽

Multiple Factor Analysis ◽

Nihss Score

Background. The correlation between H-type hypertension and acute ischemic stroke remains uncertain. Objective. The present study was designed to explore the possible relationship between H-type hypertension and severity and prognosis of acute ischemic stroke. Method. We included 372 patients with acute ischemic stroke and divided them into four groups: H-type hypertension group, simple hypertension group, simple hyperhomocysteinemia (HHcy) group, and the control group. NIHSS score was measured at both admission and two weeks later. mRS score, stroke recurrence, cardiovascular event, or all-cause mortality was recorded at 3-month and 1-year follow-up. Result. The results showed that the NIHSS score on admission in the H-type hypertension group (6.32 ± 5.91) was significantly higher than that in the control group (3.97 ± 3.59) (P < 0.05), while there was no obvious association between H-type hypertension and NIHSS score after 2-week treatment (P = 0.106). Endpoint events incidence in H-type hypertension group was the highest; however, in the cox regression model of multiple factor analysis, H-type hypertension was not an independent risk factor. Conclusion. H-type hypertension may result in early functional deterioration and higher incidence rate of endpoint events but not act as an independent risk factor.

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