Introduction/Objective. Pancreatic cancer may be accompanied by infections
caused by various microorganisms. It is uncertain wheatear pancreatic
infection precedes development of cancer or vice versa. The aim of this
study is to analyze routes of infections from duodenum through pancreatic
duct to determine what types of microorganisms can get through this duct
into pancreas and nearby tissue. Methods. In patients subjected to cephalic
duodenopancreatectomy sec. Whipple due to adenocarcinoma of papilla Vateri,
duodenum or head of the pancreas, swabs from duodenal mucosa, pancreatic
duct and pancreatic tissue at the line of the resection, were taken.
Microscopic slides were prepared directly from patients? specimens and also
from colonies on culture plates and both were Gram stained. Results.
Candida was present in all three types of swabs (duodenum, pancreatic duct
and tissue), while bacteria, depending of the species (Pseudomonas
aeruginosa. ? hemolytic Streptococcus, Coagulase Negative Staphylococcus,
Enterococcus spp, Serratia spp), were present in pancreatic duct or tissue,
but not in duodenum. Conclusion. There is connection between presence of
microorganisms and pathology of the pancreatic adenocarcinoma. Results show
that Candida infection originates from duodenum, while bacterial infections
originate directly from blood or tissue injuries.
Somatostatin levels and binding in duodenal mucosa of rabbits with ligation of the pancreatic duct
