Somatostatin levels and binding in duodenal mucosa of rabbits with ligation of the pancreatic duct
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ABSTRACT Atrophy of the exocrine pancreas was induced in rabbits by pancreatic duct ligation. Somatostatin concentration and binding in cytosol from rabbit duodenal mucosa were studied after 6 and 14 weeks of pancreatic duct ligation. Somatostatin-like immunoreactivity was significantly increased in the duodenal mucosa in both periods. Scatchard analysis showed a parallel increase in the number of binding sites rather than a change in their affinity. The physiological significance of these findings remains to be clarified. J. Endocr. (1988) 118, 227–232
1995 ◽
Vol 58
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pp. 365-374
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1979 ◽
2001 ◽
Vol 280
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pp. G555-G562
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1981 ◽
1983 ◽
Vol 117
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pp. 281-286
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