Routes and types of microbial infection in the pathology of pancreatic adenocarcinoma
Introduction/Objective. Pancreatic cancer may be accompanied by infections caused by various microorganisms. It is uncertain wheatear pancreatic infection precedes development of cancer or vice versa. The aim of this study is to analyze routes of infections from duodenum through pancreatic duct to determine what types of microorganisms can get through this duct into pancreas and nearby tissue. Methods. In patients subjected to cephalic duodenopancreatectomy sec. Whipple due to adenocarcinoma of papilla Vateri, duodenum or head of the pancreas, swabs from duodenal mucosa, pancreatic duct and pancreatic tissue at the line of the resection, were taken. Microscopic slides were prepared directly from patients? specimens and also from colonies on culture plates and both were Gram stained. Results. Candida was present in all three types of swabs (duodenum, pancreatic duct and tissue), while bacteria, depending of the species (Pseudomonas aeruginosa. ? hemolytic Streptococcus, Coagulase Negative Staphylococcus, Enterococcus spp, Serratia spp), were present in pancreatic duct or tissue, but not in duodenum. Conclusion. There is connection between presence of microorganisms and pathology of the pancreatic adenocarcinoma. Results show that Candida infection originates from duodenum, while bacterial infections originate directly from blood or tissue injuries.