In Silico Testing and in Vivo Experiments with Closed-Loop Control of Blood Glucose in Diabetes

2008 ◽  
Vol 41 (2) ◽  
pp. 4234-4239 ◽  
Author(s):  
B. Kovatchev ◽  
D.M. Raimondo ◽  
M. Breton ◽  
S. Patek ◽  
C. Cobelli
Keyword(s):  
Blood Glucose ◽  
In Silico ◽  
Closed Loop ◽  
Closed Loop Control ◽  
Loop Control ◽  
In Vivo Experiments

scholarly journals Closed-loop control system for well-defined oxygen supply in micro-physiological systems

2017 ◽  
Vol 3 (2) ◽  
pp. 363-366
Author(s):  
Tobias Steege ◽  
Mathias Busek ◽  
Stefan Grünzner ◽  
Andrés Fabían Lasagni ◽  
Frank Sonntag
Keyword(s):  
Control System ◽  
Oxygen Supply ◽  
Closed Loop ◽  
Microfluidic System ◽  
Closed Loop Control ◽  
Loop Control ◽  
Cell Vitality ◽  
Closed Loop Control System ◽  
Loop Control System

AbstractTo improve cell vitality, sufficient oxygen supply is an important factor. A deficiency in oxygen is called Hypoxia and can influence for example tumor growth or inflammatory processes. Hypoxia assays are usually performed with the help of animal or static human cell culture models. The main disadvantage of these methods is that the results are hardly transferable to the human physiology. Microfluidic 3D cell cultivation systems for perfused hypoxia assays may overcome this issue since they can mimic the in-vivo situation in the human body much better. Such a Hypoxia-on-a-Chip system was recently developed. The chip system consists of several individually laser-structured layers which are bonded using a hot press or chemical treatment. Oxygen sensing spots are integrated into the system which can be monitored continuously with an optical sensor by means of fluorescence lifetime detection.Hereby presented is the developed hard- and software requiered to control the oxygen content within this microfluidic system. This system forms a closed-loop control system which is parameterized and evaluated.

scholarly journals Proportional Insulin Infusion in Closed-Loop Control of Blood Glucose

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169135
Author(s):  
Johan Grasman ◽  
Hannah L. Callender ◽  
Marco Mensink
Keyword(s):  
Blood Glucose ◽  
Insulin Infusion ◽  
Closed Loop ◽  
Closed Loop Control ◽  
Loop Control

scholarly journals Accuracy Evaluation of Blood Glucose Monitoring Systems in Children on Overnight Closed-Loop Control

2014 ◽  
Vol 8 (5) ◽  
pp. 969-973 ◽  
Author(s):  
Daniel J. DeSalvo ◽  
Satya Shanmugham ◽  
Trang T. Ly ◽  
Darrell M. Wilson ◽  
Bruce A. Buckingham
Keyword(s):  
Blood Glucose ◽  
Closed Loop ◽  
Glucose Monitoring ◽  
Blood Glucose Monitoring ◽  
Monitoring Systems ◽  
Closed Loop Control ◽  
Accuracy Evaluation ◽  
Loop Control

Comparison of Algorithms for the Closed-Loop Control of Blood Glucose Using the Artificial Beta Cell

1981 ◽  
Vol BME-28 (10) ◽  
pp. 678-687 ◽  
Author(s):  
Henry M. Broekhuyse ◽  
Hill D. Nelson ◽  
Bernard Zinman ◽  
A. M. Albisser
Keyword(s):  
Blood Glucose ◽  
Beta Cell ◽  
Closed Loop ◽  
Closed Loop Control ◽  
Loop Control ◽  
Comparison Of Algorithms ◽  
Artificial Beta Cell

In Silico Closed-Loop Control Validation Studies for Optimal Insulin Delivery in Type 1 Diabetes

2015 ◽  
Vol 62 (10) ◽  
pp. 2369-2378 ◽  
Author(s):  
Stamatina Zavitsanou ◽  
Athanasios Mantalaris ◽  
Michael C. Georgiadis ◽  
Efstratios N. Pistikopoulos
Keyword(s):  
Type 1 Diabetes ◽  
Validation Studies ◽  
In Silico ◽  
Closed Loop ◽  
Insulin Delivery ◽  
Closed Loop Control ◽  
Loop Control
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