Facile Synthesis of 3-Aryl-5-(2-Oxopyrrolidin-1-yl)- and 5-(Pyridin-4-yl)-4,5-Dihydroisoxazoles via 1,3-Dipolar Cycloaddition under Mild Conditions

The present paper summarizes a straightforward synthesis of 4,5-dihydro-1,3,4-thiadiazoles by the 1,3-dipolar cycloaddition of thioisomünchnones. These reactions have been carried out in dichloromethane and are essentially complete within 60 min at room temperature. Under such mild conditions the asymmetric version has been explored as well. Unequivocal structure elucidation has been accomplished by means of one- and two-dimensional NMR techniques as well as X-ray structure analysis.

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ChemInform Abstract: Facile Synthesis of 3-Aryl-5-(2-oxopyrrolidin-1-yl)- and 5-(Pyridin-4-yl)-4,5-dihydroisoxazoles via 1,3-Dipolar Cycloaddition under Mild Conditions.

ChemInform ◽

10.1002/chin.201407136 ◽

2014 ◽

Vol 45 (7) ◽

pp. no-no ◽

Cited By ~ 1

Author(s):

Yan Gong ◽

Yong Wang ◽

Wen-Tao Zhao ◽

Xiang-Yang Tang

Keyword(s):

Dipolar Cycloaddition ◽

Facile Synthesis ◽

Mild Conditions

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ChemInform Abstract: Facile Synthesis of β-Lactam-Grafted Spirooxindolopyrrolidine Through Regioselective 1,3-Dipolar Cycloaddition Reaction.

ChemInform ◽

10.1002/chin.201229121 ◽

2012 ◽

Vol 43 (29) ◽

pp. no-no

Author(s):

Natarajan Arumugam ◽

Raghavachary Raghunathan

Keyword(s):

Cycloaddition Reaction ◽

Dipolar Cycloaddition ◽

Facile Synthesis

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Eco-Friendly Synthesis of Sulphonic Acid Oxime Esters Catalyzed by 2-(1H-Benzotriazole-1-yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.525.93 ◽

2014 ◽

Vol 525 ◽

pp. 93-96

Author(s):

Wei Shi ◽

Ji Ming Zhang ◽

Jian Hua Zhou ◽

Song Song Ding

Keyword(s):

High Selectivity ◽

Sulphonic Acid ◽

Present Approach ◽

High Yield ◽

Facile Synthesis ◽

Reaction Duration ◽

Mild Conditions ◽

Environmental Friendly

Herein we describle a facile synthesis of sulphonic acid oxime esters in acetonitrile from the corresponding sulphonic acids and oximes catalyzed by the environmental friendly 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) in the presence of triethylamine (TEA) under mild conditions. The present approach offers the advantages of a clean reaction, simple methodology, employing readily available catalyst, short reaction duration, high selectivity and high yield.

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Facile synthesis of 5-hydroxymethylfurfural: a sustainable raw material for the synthesis of key intermediates toward 21,23-dioxaporphyrins

RSC Advances ◽

10.1039/c5ra19400h ◽

2015 ◽

Vol 5 (121) ◽

pp. 100401-100407 ◽

Cited By ~ 11

Author(s):

Rajamani Rajmohan ◽

Subramaniyan Gayathri ◽

Pothiappan Vairaprakash

Keyword(s):

Room Temperature ◽

Solid Support ◽

Raw Material ◽

Facile Synthesis ◽

Mild Conditions

In a simple and conceptually designed method for the dehydration of fructose on a solid support, 5-hydroxymethylfurfural (HMF) was synthesized in more than 95% isolated yield from fructose under very mild conditions at room temperature.

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Rational synthesis of an atomically precise carboncone under mild conditions

Science Advances ◽

10.1126/sciadv.aaw0982 ◽

2019 ◽

Vol 5 (8) ◽

pp. eaaw0982 ◽

Cited By ~ 7

Author(s):

Zheng-Zhong Zhu ◽

Zuo-Chang Chen ◽

Yang-Rong Yao ◽

Cun-Hao Cui ◽

Shu-Hui Li ◽

...

Keyword(s):

Apex Angle ◽

Facile Synthesis ◽

Reaction Conditions ◽

X Ray ◽

Carbon Allotropes ◽

X Ray Crystallography ◽

Mild Conditions ◽

Research Opportunity ◽

Insight Into ◽

Structural Strain

Carboncones, a special family of all-carbon allotropes, are predicted to have unique properties that distinguish them from fullerenes, carbon nanotubes, and graphenes. Owing to the absence of methods to synthesize atomically well-defined carboncones, however, experimental insight into the nature of pure carboncones has been inaccessible. Herein, we describe a facile synthesis of an atomically well-defined carboncone[1,2] (C70H20) and its soluble penta-mesityl derivative. Identified by x-ray crystallography, the carbon skeleton is a carboncone with the largest possible apex angle. Much of the structural strain is overcome in the final step of converting the bowl-shaped precursor into the rigid carboncone under mild reaction conditions. This work provides a research opportunity for investigations of atomically precise single-layered carboncones having even higher cone walls and/or smaller apex angles.

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