ß-Amido Acid Functionalised Superparamagnetic Iron Oxide Nanoparticles as a Novel Carrier for Efficient Delivery of Doxorubicine

2017 ◽  
Vol 41 (3) ◽  
pp. 129-135
Author(s):  
Fatemeh Ebrahimi ◽  
Maryam Karimi ◽  
Hasan Sereshti ◽  
Mohsen Yousefifar
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Precipitation Method ◽  
Hydrodynamic Diameter ◽  
Oxide Nanoparticles ◽  
Amido Acid

Superparamagnetic iron oxide nanoparticles are increasingly used in medical applications due to their unique physical properties. They are useful carriers for delivering antitumour drugs in targeted cancer treatment. In this study, amido acid-functionalised magnetic nanoparticles (AAFMNs) are used as drug-delivery vehicles for doxorubicine as an efficient tool for the treatment of cancer. Magnetic iron oxide nanoparticles were synthesised using a co-precipitation method. The prepared iron oxide nanoparticles were then functionalised with amido acid functional groups. Finally, the synthesised AAFMNs were used for the delivery of doxorubicine. AAFMNs were characterised by Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis and zeta potential. An in vitro-determined hydrodynamic diameter of ∼80 nm suggested their applicability for this purpose. The findings show that AAFMNs are a promising tool for potential magnetic drug delivery.

Ultra-Small Superparamagnetic Iron Oxide Nanoparticles as MRI Contrast Enhancing Agents

2008 ◽  
Vol 47-50 ◽  
pp. 1076-1079
Author(s):  
M.A. Do ◽  
H.J. Lee ◽  
J.H. Yeum ◽  
Y.M. Chang ◽  
H.D. Ghim ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Particle Size Analysis ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Precipitation Method ◽  
Size Analysis ◽  
Oxide Nanoparticles ◽  
Co Precipitation

Ultrasmall superparamagnetic iron oxide nanoparticles (USPION) as magnetic resonance imaging were synthesized through a sonochemical co-precipitation method with poly (ethyleneimine) (PEI). The size of the USPION was controlled by poly (ethyleneimine) (PEI) contents, ultrasonic exposure time, and Na4OH concentration. The characteristics of PEI-USPION were studied by X-ray diffractometry, magnetic property measurement system, scanning electron microscopy, transmission electron microscopy, and particle size analysis. The PEI-USPION had an average size of 5~10nm with a narrow size distribution, a perfect magnetite crystal structure, and high saturation magnetization.

scholarly journals Structural and dielectric properties of superparamagnetic iron oxide nanoparticles (SPIONs) stabilized by sugar solutions

2018 ◽  
Vol 36 (1) ◽  
pp. 123-133 ◽  
Author(s):  
D. Siva Kumar ◽  
K. Chandra Babu Naidu ◽  
M. Mohamed Rafi ◽  
K. Prem Nazeer ◽  
A. Ayisha Begam ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Dielectric Properties ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Interfacial Polarization ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Precipitation Method ◽  
Oxide Nanoparticles ◽  
Cole Plot ◽  
Magnetic Studies

Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) have been synthesized using co-precipitation method. Their microstructure and dielectric properties were studied. The sugar solutions like glucose, fructose and sucrose were used as stabilizers to control the size of the SPIONs. The crystal structure and grain size of the particles were determined by X-ray diffraction. The magnetic studies of the samples were carried out using the vibrating sample magnetometer and their surface morphology was studied by HRTEM, FE-SEM and zeta potential. The dielectric properties of glucose-SPIONs (GF), fructose-SPIONs (FF) and sucrose-SPIONs (SF) were investigated in the frequency range of 10 Hz to 5 MHz at selected temperatures. The FF showed a high dielectric constant of 62 at 1 MHz and the dielectric properties of SPIONs were found to have been significantly improved, especially in the low frequency regime according to the Maxwell-Wagner interfacial polarization. The AC conductivity measurements revealed that the electrical conduction depends on both frequency and temperature. Impedance analysis was carried out using Cole-Cole plot and the conduction mechanism of the studied compounds was explained. R and C values were further calculated using RC-circuit.

Preparation, characterization and application of superparamagnetic iron oxide nanoparticles modified with natural polymers for removal of 60Co-radionuclides from aqueous solution

2017 ◽  
Vol 105 (2) ◽  
Author(s):  
Gehan E. Sharaf El-Deen ◽  
Neama G. Imam ◽  
Refaat R. Ayoub
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Precipitation Method ◽  
Oxide Nanoparticles ◽  
Natural Polymers ◽  
Ft Ir ◽  
Co Precipitation ◽  
Ft Ir Spectroscopy

AbstractSuperparamagnetic iron oxide nanoparticles (IO-MNPs) coated with natural polymers, starch (IO-S MNPs) and dextrin (IO-D MNPs), were synthesized by modified co-precipitation method. IO and hybrid-IO-MNPs were characterized by XRD, SEM, HRTEM, FT-IR spectroscopy, vibrating sample magnetometer (VSM) and zeta potential (ZP). IO-S MNPs and IO-D MNPs have IO core-shell structure with core of 10.8 nm and 13.8 nm and shell of 7.5 nm and 5.9 nm, respectively. The efficiency of the hybrid IO-MNPs for sorption of

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