Synthesis, crystal Structure, antitumour activity of (3-amino-4-morph olino-1H-indazol-1-yl)(3-fluorophenyl)methanone_ESI

2018 ◽  
Keyword(s):  
Crystal Structure ◽  
Antitumour Activity

Synthesis, characterization, X-ray crystal structure andin vitro antitumour activity of sodium bis(2-(3′,6′,9′-trioxadecyl)-1,2-dicarba-closo-dodecaborane-1-carboxylato)triphenylstannate

2004 ◽  
Vol 18 (4) ◽  
pp. 191-194 ◽  
Author(s):  
V. I. Bregadze ◽  
S. A. Glazun ◽  
P. V. Petrovskii ◽  
Z. A. Starikova ◽  
A. G. Buyanovskaya ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Antitumour Activity ◽  
X Ray

Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-N-(5-Fluoro-2-Methylphenyl)-4-Morpholino-1H-Indazole-1-Carboxamide

2017 ◽  
Vol 41 (11) ◽  
pp. 624-626 ◽  
Author(s):  
Xue-chen Hao ◽  
Jiu-fu Lu ◽  
Ye Chen ◽  
Yang Wang ◽  
Shi Ding ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Hydrazine Hydrate ◽  
Cell Lines ◽  
Cancer Cell ◽  
Title Compound ◽  
Antitumour Activity ◽  
Cancer Cell Lines

Compound 3-amino- N-(5-fluoro-2-methylphenyl)-4-morpholino-1 H-indazole-1-carboxamide has been synthesised by condensation of 4-fluoro-2-isocyanato-1-methylbenzene with 4-morpholino-1 H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the compound inhibits proliferation of some cancer cell lines.

Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-N-[4-chloro-3-(Trifluoromethyl)Phenyl]-4-Morpholino-1H-Indazole-1-Carboxamide

2018 ◽  
Vol 42 (10) ◽  
pp. 504-507
Author(s):  
Xiao-hui Ji ◽  
Ling-xia Jin ◽  
Cai-bin Zhao ◽  
Nan Zheng ◽  
Juan Song ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Hydrazine Hydrate ◽  
Cell Lines ◽  
Cancer Cell ◽  
Title Compound ◽  
Antitumour Activity ◽  
Cancer Cell Lines ◽  
Inhibitory Capacity

Compound 3-amino-N-[4-chloro-3-(trifluoromethyl)phenyl]-4-morpholino-1H-indazole-1-carboxamide has been synthesised by condensation of 1-chloro-4-isocyanato-2-(trifluoromethyl)benzene with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the compound possesses a distinct inhibitory capacity against proliferation of the A549 and BGC-823 cancer cell lines.

Synthesis, Crystal Structure and Antitumour Activity of Ethyl 2-[(2-Amino-3-Cyano-4-Phenethyl-4H-Naphtho[1,2-b]Pyran-8-yl)Oxy]acetate

2018 ◽  
Vol 42 (9) ◽  
pp. 486-489 ◽  
Author(s):  
Ju Liu ◽  
Jian-Tao Shi ◽  
Xue-Chen Hao ◽  
Yu-Tong Liu ◽  
Shi Ding ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cell Lines ◽  
Hydroxy Group ◽  
Cancer Cell ◽  
Title Compound ◽  
Room Temperature ◽  
Knoevenagel Condensation ◽  
Antitumour Activity ◽  
Cancer Cell Lines

Ethyl 2-[(2-amino-3-cyano-4-phenethyl-4 H-naphtho[1,2- b]pyran-8-yl)oxy]acetate has been synthesised by condensation of ethyl 2-chloroacetate with the hydroxy group of 2-amino-8-hydroxy-4-phenethyl-4 H-naphtho[1,2- b]pyran-3-carbonitrile. The latter was prepared from cinnamaldehyde, malononitrile and naphthalene-1,6-diol through Knoevenagel condensation and cyclisation reaction and then reduction with hydrogen in the presence of Pd/C at room temperature. The crystal structure of the title compound was determined. In addition, the compound showed distinct inhibition of the proliferation of some cancer cell lines.

Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-4-Morpholino-1H-Indazol-1-yl(3-Fluorophenyl)Methanone

2018 ◽  
Vol 42 (11) ◽  
pp. 552-555
Author(s):  
Zhi-hua Tang ◽  
Wei-Jun Fu
Keyword(s):  
Molecular Structure ◽  
Crystal Structure ◽  
Single Crystal ◽  
Hydrazine Hydrate ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antitumour Activity ◽  
X Ray Diffraction ◽  
X Ray ◽  
Biological Tests

3-Amino-4-morpholino-1H-indazol-1-yl(3-fluorophenyl)methanone was synthesised by condensation of 3-fluorobenzoic acid with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The molecular structure was tested by single crystal X-ray diffraction. Preliminary biological tests showed that the compound possesses distinct inhibition on the proliferation of A549, BGC-823 and HepG-2 cancer cell lines.

Synthesis, characterization, X-ray crystal structure andin vitro antitumour activity of bis(1,2-dicarba-closo-dodecaborane-9-carboxylato)di-n-butyltin

2003 ◽  
Vol 17 (6-7) ◽  
pp. 453-457 ◽  
Author(s):  
Vladimir I. Bregadze ◽  
Sergey A. Glazun ◽  
Pavel V. Petrovskii ◽  
Zoya A. Starikova ◽  
Valery Ya. Rochev ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Antitumour Activity ◽  
X Ray
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