This chapter discusses the role Europe’s long history of conflict over geography, religion, and national identity, as well as its aristocratic traditions, on modern European populism. The Brexit referendum gave direct electoral voice to the accumulated resentments of populist forces in the United Kingdom against EU rules administered by what its supporters regarded as an elite bureaucracy in Brussels. Their concerns, mainly over budgetary and regulatory issues, overrode the prospect of losing trade benefits from the EU single market. Elsewhere in the European Union populist parties continue to be active, and many of them are Euroskeptic, based largely on immigration and monetary issues. Many right-wing and left-wing populist parties in particular tend to favor protectionism, but will not be in a position to challenge centralized EU trade policy until they gain power in large EU countries. The UK exit from the European Union will weaken a prominent pro-trade voice in the EU Council of Ministers.