Influence of single nucleotide polymorphism rs9527281 of STARD13 gene on the severity of clinical manifestations of multiple sclerosis

2019 ◽  
Vol 17 (7) ◽  
pp. 55-59
Author(s):  
E. E. Arbuzova ◽  
◽  
N. V. Selyanina ◽  
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphism ◽  
Clinical Manifestations ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis

2012 ◽  
Vol 45 (6) ◽  
pp. 757-760 ◽  
Author(s):  
Elizabeth de Souza Neves ◽  
André Luis Land Curi ◽  
Maira Cavalcanti de Albuquerque ◽  
Cassius Schnel Palhano-Silva ◽  
Laura Berriel da Silva ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Case Control Study ◽  
Severe Disease ◽  
Clinical Manifestations ◽  
Nucleotide Polymorphism ◽  
Gene Encoding ◽  
Single Nucleotide ◽  
Duration Of Disease ◽  
Acute Toxoplasmosis ◽  
Control Study

INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.

Infectious mononucleosis-linked HLA class I single nucleotide polymorphism is associated with multiple sclerosis

2010 ◽  
Vol 16 (11) ◽  
pp. 1303-1307 ◽  
Author(s):  
Naghmeh Jafari ◽  
Linda Broer ◽  
Ilse A Hoppenbrouwers ◽  
Cornelia M van Duijn ◽  
Rogier Q Hintzen
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphism ◽  
Infectious Mononucleosis ◽  
Risk Allele ◽  
Hla Class I ◽  
Class I ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Major Class ◽  
A Minor

Background: Multiple sclerosis is a presumed autoimmune disease associated with genetic and environmental risk factors such as infectious mononucleosis. Recent research has shown infectious mononucleosis to be associated with a specific HLA class I polymorphism. Objectives: Our aim was to test if the infectious mononucleosis-linked HLA class I single nucleotide polymorphism (rs6457110) is also associated with multiple sclerosis. Methods: Genotyping of the HLA-A single nucleotide polymorphism rs6457110 using TaqMan was performed in 591 multiple sclerosis cases and 600 controls. The association of multiple sclerosis with the HLA-A single nucleotide polymorphism was tested using logistic regression adjusted for age, sex and HLA-DRB1*1501. Results: HLA-A minor allele (A) is associated with multiple sclerosis (OR = 0.68; p = 4.08 × 10 -5). After stratification for HLA-DRB1*1501 risk allele (T) carrier we showed a significant OR of 0.70 ( p = 0.003) for HLA-A. Conclusions: HLA class I single nucleotide polymorphism rs6457110 is associated with infectious mononucleosis and multiple sclerosis, independent of the major class II allele, supporting the hypothesis that shared genetics may contribute to the association between infectious mononucleosis and multiple sclerosis.

HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica

2010 ◽  
Vol 16 (8) ◽  
pp. 981-984 ◽  
Author(s):  
Marcelo Matiello ◽  
Janet Schaefer-Klein ◽  
Doralina G Brum ◽  
Elizabeth J Atkinson ◽  
Orhun H Kantarci ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphism ◽  
Association Study ◽  
Neuromyelitis Optica ◽  
Genetic Association Study ◽  
Case Control ◽  
Small Populations ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Nuclease Assay

Background: Association of the HLA-DRB1*1501 allele with multiple sclerosis is well established, but its association with neuromyelitis optica has only been evaluated in small populations. Methods: We performed a case-control genetic association study to evaluate the association of HLA-DRB1*1501 with neuromyelitis optica. The single nucleotide polymorphism rs3135388, which tags HLA-DRB1*1501, was genotyped in 164 patients with neuromyelitis optica, 220 patients with multiple sclerosis and 959 controls matched for age, gender and ethnicity. Genotyping for rs3135388 was performed by Taqman-based 5' nuclease assay. Results: Rs3135388*A was positively associated with multiple sclerosis (OR = 3.93; 95% CI = 2.58—5.97, p = 1.18 × 10-09) but negatively associated with NMO (OR = 0.57; 95% CI = 0.36—0.91, p = 0.01). Conclusions: Multiple sclerosis and neuromyelitis optica differ in their associations with DRB1*1501.

A single nucleotide polymorphism within Ninjurin 2 is associated with risk of multiple sclerosis

2019 ◽  
Vol 34 (5) ◽  
pp. 1415-1419 ◽  
Author(s):  
Rezvan Noroozi ◽  
Iman Azari ◽  
Mohammad Taheri ◽  
Mir Davood Omrani ◽  
Soudeh Ghafouri-Fard
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphism ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

CD24 V/V is an allele associated with the risk of developing multiple sclerosis in the Spanish population

2006 ◽  
Vol 12 (4) ◽  
pp. 511-514 ◽  
Author(s):  
D Otaegui ◽  
A Sáenz ◽  
P Camaño ◽  
L Blázquez ◽  
M Goicoechea ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphism ◽  
Spanish Population ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Population Bias

The allele C in the CD24 gene has been related to multiple sclerosis (MS). In this work we check this single nucleotide polymorphism (SNP) in a population of 135 patients and 285 controls. Our results confirm the association between the V/V genotype at aa 57 of this gene and MS and highlight the importance of taking into account the origin of the subjects to avoid a population bias.

scholarly journals Correlation between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility. A meta-analysis

Open Medicine ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. 264-269 ◽  
Author(s):  
Xiao Haibing ◽  
Cao Xu ◽  
Cai Jifu ◽  
Zeng Wenshuang ◽  
Li Ling ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphism ◽  
Genetic Model ◽  
Cytotoxic T Lymphocyte ◽  
Meta Analysis ◽  
Current Evidence ◽  
Nucleotide Polymorphism ◽  
China National Knowledge Infrastructure ◽  
Single Nucleotide ◽  
Multiple Sclerosis Susceptibility

AbstractObjectiveThe aim of this meta-analysis was to undertake a meta-analysis to evaluate the correlation between cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene rs221775 A>G single nucleotide polymorphism and the susceptibility of multiple sclerosis (MS) susceptibility.MethodPublished manuscripts about CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility were searched in the computerized bibliographic searches of Pubmed Embase and China National Knowledge Infrastructure (CNKI). Potential studies were screened and data for 5025 MS patients and 4706 controls from 20 publications were included. The association between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility were demonstrated by odds ratio (OR) and 95% confidence interval (95%CI).ResultsThe pooled results showed no significant association between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility for dominant genetic model [OR=1.02, 95%CI:0.90~1.05, (P=0.80)], homozygous genetic model [OR=0.85,95%CI:0.71 ~1.03,(P=0.10)] and recessive genetic model [OR=0.99,95% CI:0.89~1.10,(P=0.90)].ConclusionWith current evidence, CTLA-4 gene rs221775A>G single nucleotide polymorphism had no association with the susceptibility of multiple sclerosis

scholarly journals WHAT IS THE IMPACT OF IL12B+1188 SINGLE NUCLEOTIDE POLYMORPHISM ON IL-12 SERUM LEVEL of MULTIPLE SCLEROSIS IRAQI PATIENTS?

2016 ◽  
Vol 4 (9) ◽  
pp. 2276-2281
Author(s):  
MeeladA. Al-Nasiri ◽  
◽  
EhabD. Salman ◽  
AliH. Ad’hiah ◽  
SarmadA. Al-Mashtah ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphism ◽  
Serum Level ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
The Impact
Sign in / Sign up

Export Citation Format

Share Document