Internal viscosity of the red cell: Problems associated with definition of plasma viscosity and effective volume of red cells in the blood viscosity equation1

Biorheology ◽  
1975 ◽  
Vol 12 (3-4) ◽  
pp. 253-256 ◽  
Author(s):  
L. Dintenfass
Keyword(s):  
Blood Viscosity ◽  
Plasma Viscosity ◽  
Red Cells ◽  
Red Cell ◽  
Effective Volume ◽  
Definition Of ◽  
Internal Viscosity

Viscosity and Red Cell Deformity in Arterial Disease

1979 ◽  
Author(s):  
G Cella ◽  
H de Haas ◽  
M Rampling ◽  
V Kakkar
Keyword(s):  
Vascular Disease ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Arterial Disease ◽  
Plasma Viscosity ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Red Cell ◽  
Whole Blood Viscosity ◽  
Significant Difference

Haemorrheological factors have been shown to be affected in many kings of vascular disease. The present study was undertaken to correlate these factors in normal subjects and patients suffering from peripheral arterial disease. Twenty-two patients were investigated; they had moderate or severe intermittent claudication, extent of disease being confirmed by aorto-arteriography and ankle-systolic pressure studies. Twenty-five controls with no symptoms or signs of arterial disease were selected with comparable age and sex distribution. Whole blood viscosity was measured at shear rates of 230 secs-1 and 23 secs-lat 37°c using a Wells Brookfield cone plate microvisco meter. Plasma viscosity was also measured in an identical manner. Erythrocyte flexibility was measured by centrifuge technique and fibrinogen concentration as well as haematocrit by standard techniques. The fibrinogen concentration appeared to be the only significant parameter; the mean concentration in patients with peripheral vascular disease of 463 ± 73mg/l00ml in the control group ( < 0.05). Although whole blood viscosity was high in patients, when corrected to a common haematocrit, there was no significant difference between patients and controls. The same megative correlation was found for plasma viscosity. The red cell flexibility was found to be increased in patients as compared to the control group, but this effect appeared to be simply proportional to the fibrinogen concentration.

Blood and plasma viscosity of winter flounder: influence of temperature, red cell concentration, and shear rate

1983 ◽  
Vol 61 (10) ◽  
pp. 2344-2350 ◽  
Author(s):  
Mark S. Graham ◽  
Garth L. Fletcher
Keyword(s):  
Shear Rate ◽  
Blood Viscosity ◽  
Cell Concentration ◽  
Plasma Viscosity ◽  
Winter Flounder ◽  
Red Cell ◽  
Pseudopleuronectes Americanus ◽  
Total Blood ◽  
Influence Of Temperature ◽  
Rate Dependent

The effects of temperature, red cell concentration, and shear rate on the viscosity of blood from the winter flounder (Pseudopleuronectes americanus) were evaluated using a cone-plate viscometer. The viscosity of blood and plasma was shear rate dependent at all temperatures studied (−1 to 20 °C) with the highest values occurring at the lowest temperature and shear rate. At normal hematocrits (20%), plasma appeared to account for at least 50% of the total blood viscosity. The effects of hematocrit on viscosity were dependent on temperature. At higher temperatures (10–20 °C), increases in hematocrit resulted in a near-exponential increase in viscosity. At lower temperatures (5 °C) and shear rates (4.5 s−1) no significant increase in viscosity occurred between hematocrits of 11 and 43%. The influence of temperature and shear rate on blood viscosity suggest that winter flounder may have to contend with a fivefold increase in blood viscosity when acclimating from summer to winter water temperatures.

Internal Viscosity of the Red Cell and a Blood Viscosity Equation

Nature ◽  
1968 ◽  
Vol 219 (5157) ◽  
pp. 956-958 ◽  
Author(s):  
LEOPOLD DINTENFASS
Keyword(s):  
Blood Viscosity ◽  
Red Cell ◽  
Internal Viscosity

Viscosity and Red Cell Deformity in Arterial Disease

1979 ◽  
Author(s):  
G. Cella ◽  
H.A. de Haas ◽  
M. Rampling ◽  
V.V. Kakkar
Keyword(s):  
Vascular Disease ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Arterial Disease ◽  
Plasma Viscosity ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Red Cell ◽  
Whole Blood Viscosity ◽  
Significant Difference

Haemorrheological factors have been shown to be affected in many kings of vascular disease. The present study was undertaken to correlate these factors in normal subjects and patients suffering from peripheral arterial disease. Twenty-two patients were investigated; they had moderate or severe intermittent claudication, extent of disease being confirmed by aorto-arteriography and ankle-systolic pressure studies. Twenty-five controls with no symptoms or signs of arterial disease were selected withcomparable age and sex distribution. Whole blood viscosity was measured at shear rates of 230 secs-1 and 23 sees-1 at 37°C using a Weils Brookfield cone plate microvisco meter. Plasma viscosity was also measured in an identical manner. Erythrocyte flexibility was measured by centrifuge technique and fibrinogen concentration as well as haematocrit by standard techniques. The fibrinogen concentration appeared to be the only significant parameter; the mean concentration in patients with peripheral vascular disease of 463 ± 73mg/100ml in the control group ( 〈 0.05). Although whole blood viscosity was high in patients, when corrected t. a common haematocrit, there was no significant difference between patients and controls The same megative correlation was found for plasma viscosity. The red cell flexibility was found to be increased in patients as compared to the control group, but this effect appeared to be simply proportional to the fibrinogen concentration.

Blood Viscosity Variations During Raynaud’s Phenomenon

1979 ◽  
Author(s):  
S. Forconi
Keyword(s):  
Cell Volume ◽  
Blood Viscosity ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Red Cells ◽  
The Other ◽  
Fibrinogen Concentration ◽  
Red Cell ◽  
The Moment ◽  
Viscosity Changes

Since several authors have found abnormal blood viscosity in patients suffering from Raynaud’s disease but did not study them at the moment when the phenomenon appeared, we want to find out whether haemorheological changes might be provoked in the patients during a cold-induced phenomenon. The study was conducted on ten selected patients suffering from Raynaud’s phenomenon only in one hand when exposed to cold. A relevant and statistically very significant increase of the viscosity was noted in the blood coming from the hand during the cold-induced ischemia. When the ischemia had disappeared, blood viscosity levels returned to those recorded before the experience. No variations were evident in either plasma and serum viscosity, or in packed red cell volume and in plasma fibrinogen concentration. In the other arm of the same patients, a much smaller increase in blood viscosity was noted. No variations were found in any of the parameters observed in six control subjects. These results seems to suggest that blood viscosity changes specifically in relation to the disease, that this change may be related to the behaviour of the red cells (increased aggregability or decreased deformability) as the consequence of the ischemia, and that this hyperviscosity may potentiate the hindrance to the flow at the microcirculatory level.

scholarly journals In Vitro Measurements of the Effects of Anticoagulants on the Flow Properties of Blood: The Relationship of these Effects to Red Cell Shrinkage

Blood ◽  
1968 ◽  
Vol 31 (2) ◽  
pp. 234-241 ◽  
Author(s):  
WILLIAM I. ROSENBLUM
Keyword(s):  
Cell Size ◽  
Blood Viscosity ◽  
Plasma Viscosity ◽  
Red Cell ◽  
Flow Properties ◽  
Cell Shrinkage ◽  
In Vitro Measurements ◽  
Relationship Of ◽  
The Relationship

Abstract Citrate and oxalate increased the viscosity of blood as measured in a capillary viscosimeter. The elevated viscosity was accompanied by erytrhocyte shrinkage, manifest by the decreased hematocrit of blood anticoagulated with either of these agents. Plasma viscosity was not affected. EDTA, which does not alter cell size or shape, also failed to alter blood viscosity, while citrate no longer affected viscosity, if utilized in ACD solution, a milieu which prevents cell shrinkage. When erythrocytes were suspended in hypertonic NaCl, "blood" viscosity was also elevated in comparison to that of suspensions in lower concentrations of NaCl. The data indicate that blood viscosity will be elevated by anticoagulants which are permitted to shrink erythrocytes.

Abnormal Blood Rheology in Young Male Diabetics with and without Retinopathy

1979 ◽  
Author(s):  
G.D.O. Lowe ◽  
M.M. Drummond ◽  
J.J.F. Belch ◽  
J.M. Lowe ◽  
A.C. MacCuish ◽  
...  
Keyword(s):  
Blood Viscosity ◽  
Smoking Habit ◽  
Vascular Complications ◽  
Young Male ◽  
Blood Rheology ◽  
Plasma Viscosity ◽  
Red Cell ◽  
Cell Deformability ◽  
Rotational Viscometer ◽  
Red Cell Deformability

We compared red cell deformability (filtration rate through 5 μ sieves), blood viscosity (rotational viscometer), haematocrit, plasma fibrinogen and plasma viscosity in young male diabetics (age <50 years) and normal controls matched for age and smoking habit. diabetics with no retinopathy or other vascular complications (n = 20) had normal red cell deformability, but increased blood viscosity at shear rates of 100s-1 (p<0.05) and is-1 (p<0. 01), due in part to moderate elevations of haematocrit, fibrinogen and plasma viscosity. Diabetics with retinopathy (n = 10) had a more marked increase in viscosity and also reduced red cell deformability (p<0.05). Increased blood viscosity is present prior to the onset of detectable vascular complications in male diabetics, while reduced red cell deformability is associated with complications.

Sign in / Sign up

Export Citation Format

Share Document