Single nucleotide polymorphism rs2274084 of gap junction protein beta 2 gene among Epstein-Barr virus-associated tumors

2018 ◽  
Vol 21 (3) ◽  
pp. 499-504 ◽  
Author(s):  
Hua Xiao ◽  
Wen Liu ◽  
Zhenzhen Zhao ◽  
Yan Zhang ◽  
Yingying Song ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Epstein Barr Virus ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Barr Virus ◽  
Junction Protein ◽  
Gap Junction Protein ◽  
Beta 2 ◽  
Epstein Barr ◽  
Associated Tumors

scholarly journals CpG methylation in cell-free Epstein-Barr virus DNA in patients with EBV-Hodgkin lymphoma

2020 ◽  
Vol 4 (8) ◽  
pp. 1624-1627
Author(s):  
Meir Shamay ◽  
Jennifer A. Kanakry ◽  
John S. W. Low ◽  
Netanel A. Horowitz ◽  
Guy Journo ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Epstein Barr Virus ◽  
Magnetic Beads ◽  
Immunocompromised Patients ◽  
Viral Dna ◽  
Barr Virus ◽  
Latently Infected ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Associated Tumors

Abstract Epstein-Barr virus (EBV) is associated with a variety of tumors and nonmalignant conditions. Latent EBV genomes in cells, including tumor cells, are often CpG methylated, whereas virion DNA is not CpG methylated. We demonstrate that methyl CpG binding magnetic beads can be used to fractionate among sources of EBV DNA (DNA extracted from laboratory-purified virions vs DNA extracted from latently infected cell lines). We then applied the technique to plasma specimens and showed that this technique can distinguish EBV DNA from patients with EBV-associated tumors (nasopharyngeal carcinoma, Hodgkin lymphoma) and viral DNA from patients without EBV-associated tumors, including immunocompromised patients and patients with EBV(−) Hodgkin lymphoma.

scholarly journals Clinical utility of plasma Epstein-Barr virus DNA andERCC1single nucleotide polymorphism in nasopharyngeal carcinoma

Cancer ◽  
2015 ◽  
Vol 121 (16) ◽  
pp. 2720-2729 ◽  
Author(s):  
Edwin P. Hui ◽  
Brigette B. Y. Ma ◽  
K. C. Allen Chan ◽  
Charles M. L. Chan ◽  
Cesar S. C. Wong ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Clinical Utility ◽  
Epstein Barr Virus ◽  
Nucleotide Polymorphism ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Association of TGF-β2 Gene Polymorphism with Salmonella pullorum Bacterial Infection Resistance in Tolaki Chickens

2020 ◽  
pp. 46-54
Author(s):  
Muh Akramullah ◽  
Cece Sumantri ◽  
Niken Ulupi
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Growth Factor ◽  
Bacterial Infection ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Infection Resistance ◽  
Salmonella Pullorum ◽  
Growth Factor Beta ◽  
Beta 2 ◽  
Leucocyte Concentration

Transformation growth factor-beta 2 gene (TGF-β2) is a gene which belongs to the cytokine gene group. The present study aimed to identify Single Nucleotide Polymorphism (SNP) g. 640 T> C of Transformation growth factor-beta 2 gene (TGF-β2) and associate its genotypes with Salmonella pullorum Bacterial Infection Resistance in Tolaki Chickens. This study used blood samples collected from 70 chickens. Discussion was conducted on leucocyte concentration, leucocyte differentiation (heterophils, monocytes, lymphocytes, eosinophils, basophils and H/L ratio) and clearance test. Identification of Single Nucleotide Polymorphism of Transformation growth factor-beta 2 gene (TGF-β2) was performed by PCR-RFLP method. Association of (SNP) g. 640 T> C of Transformation growth factor-beta 2 gene (TGF-β2) with leukocyte profiles and their differentiation and resistance to bacterial infections was carried out using analysis of variance with GLM (General Linear Model). SNP g.640 T> C of Transformation growth factor-beta 2 gene (TGF-β2) was polymorphic and was in Hardy-Weinberg equilibrium. Based on molecular and biological testing, Tolaki chickens in genotypes (TT, TC and CC) have normal leucocyte concentration and differenciation and resistant to Salmonella pullorum.

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