scholarly journals Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy

2021 ◽  
pp. 1-11
Author(s):  
Nontiya Homkham ◽  
Pooriwat Muangwong ◽  
Veeradej Pisprasert ◽  
Patrinee Traisathit ◽  
Rungarun Jiratrachu ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Immune System ◽  
Cancer Patients ◽  
Concurrent Chemoradiotherapy ◽  
Absolute Lymphocyte Count ◽  
Diet Group ◽  
Cancer Therapies ◽  
Dynamic Changes ◽  
Regular Diet ◽  
Over Time

BACKGROUND: Immune-enhancing nutrition (IMN) strengthens the systematic inflammatory response and the immune system. Neutrophil to lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) are affected during cancer therapies. OBJECTIVE: We carried out an analysis of the dynamic changes in NLR and ALC over time in cancer patients with or without IMN supplementation. METHODS: 88 cancer patients receiving concurrent chemoradiotherapy (CCRT) were randomized into regular diet group, and regular diet and IMN group.Generalized estimation equation models were used to assess associations between patient’s characteristics, IMN, and dynamic changes in NLR and ALC over time. RESULTS: NLR and ALC at preCCRT were significantly associated with dynamic changes in NLR (adjusted β= 1.08, 95% confidence interval [CI]: 0.64–1.52) and ALC (adjusted β= 0.41, 95% CI: 0.36–0.46). The magnitudes of the NLR and ALC changes through CCRT were lower in patients receiving IMN, although the differences were not statistically significant except ALC at the end of CCRT in head and neck cancer patients (P= 0.023). CONCLUSION: Dynamic negative changes in both markers were demonstrated throughout CCRT. There were non-significant trend in promising changes in both NLR and ALC values in the whole group in IMN supplementation.

scholarly journals Factors associated with depression over time in head and neck cancer patients: A systematic review

2019 ◽  
Vol 28 (6) ◽  
pp. 1159-1183 ◽  
Author(s):  
Laura H.A. Korsten ◽  
Femke Jansen ◽  
Ben J.F. Haan ◽  
Danielle Sent ◽  
Pim Cuijpers ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Factors Associated ◽  
Over Time

scholarly journals Analysis of thromboembolic events in head and neck cancer patients who underwent concurrent chemoradiotherapy with cisplatin: A real-world study

2021 ◽  
Author(s):  
Hundo Cho ◽  
Seok Yun Kang ◽  
Hyun Woo Lee ◽  
Yong Won Choi ◽  
Tae-Hwan Kim ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
General Population ◽  
Head And Neck ◽  
Cancer Patients ◽  
Incidence Rate ◽  
Neck Cancer ◽  
Real World ◽  
Concurrent Chemoradiotherapy ◽  
Thromboembolic Events ◽  
Factors Affecting

Abstract Background The risk of thromboembolic events (TEE) in cancer patients, especially those receiving cisplatin-based chemotherapy, is higher than that of general population. Methods The study investigated the incidence of TEE in 257 head and neck (H&N) cancer patients, during or within 6 months of completion of concurrent chemoradiotherapy (CCRT) with cisplatin, and analyzed factors affecting TEE occurrence. Results TEE occurred in 5 patients, an incidence rate of 1.9%. Khorana score was the only factor associated with TEE occurrence (p = 0.010). Conclusions The incidence of TEE in H&N cancer patients who underwent CCRT with cisplatin was relatively low when compared to other types of cancer. However, patients with a high Khorana score require more careful surveillance for possible TEE occurrence.

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