scholarly journals Genome-Wide Scan of Copy Number Variation in Late-Onset Alzheimer's Disease

2010 ◽  
Vol 19 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Erin L. Heinzen ◽  
Anna C. Need ◽  
Kathleen M. Hayden ◽  
Ornit Chiba-Falek ◽  
Allen D. Roses ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copy Number Variation ◽  
Copy Number ◽  
Late Onset ◽  
Genome Wide ◽  
Number Variation ◽  
Genome Wide Scan

scholarly journals Genome-Wide Scan for Copy Number Variation Association with Age at Onset of Alzheimer's Disease

2012 ◽  
Vol 33 (2) ◽  
pp. 517-523 ◽  
Author(s):  
Kinga Szigeti ◽  
Deepika Lal ◽  
Yanchun Li ◽  
Rachelle S. Doody ◽  
Kirk Wilhelmsen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copy Number Variation ◽  
Copy Number ◽  
Age At Onset ◽  
Genome Wide ◽  
Number Variation ◽  
Genome Wide Scan

scholarly journals Genome-wide copy-number variation study of psychosis in Alzheimer’s disease

2015 ◽  
Vol 5 (6) ◽  
pp. e574-e574 ◽  
Author(s):  
X Zheng ◽  
F Y Demirci ◽  
M M Barmada ◽  
G A Richardson ◽  
O L Lopez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copy Number Variation ◽  
Copy Number ◽  
Genome Wide ◽  
Number Variation

P1-053: OLFACTORY RECEPTOR COPY NUMBER VARIATION INVOLVED IN ALZHEIMER'S DISEASE

2014 ◽  
Vol 10 ◽  
pp. P322-P323
Author(s):  
Caroline Van Cauwenberghe ◽  
Karolien Bettens ◽  
Sebastiaan Engelborghs ◽  
Mathieu Vandenbulcke ◽  
Rik R. Vandenberghe ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copy Number Variation ◽  
Olfactory Receptor ◽  
Copy Number ◽  
Number Variation

Analysis of Copy Number Variation in Alzheimer’s Disease: The NIALOAD/ NCRAD Family Study

2012 ◽  
Vol 9 (7) ◽  
pp. 801-814 ◽  
Author(s):  
Shanker Swaminathan ◽  
Li Shen ◽  
Sungeun Kim ◽  
Mark Inlow ◽  
John D. West ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copy Number Variation ◽  
Copy Number ◽  
Family Study ◽  
Number Variation

P1-097: Identifying Copy Number Variation influencing risk for Alzheimer's disease in the Amish

2010 ◽  
Vol 6 ◽  
pp. S202-S202
Author(s):  
O.J. Veatch ◽  
D.R. Velez Edwards ◽  
W.K. Scott ◽  
J.R. Gilbert ◽  
M.A. Pericak-Vance ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copy Number Variation ◽  
Copy Number ◽  
Number Variation

scholarly journals Ordered Subset Analysis of Copy Number Variation Association with Age at Onset of Alzheimer's Disease

2014 ◽  
Vol 41 (4) ◽  
pp. 1063-1071 ◽  
Author(s):  
Kinga Szigeti ◽  
Blanka Kellermayer ◽  
Jenna M. Lentini ◽  
Brian Trummer ◽  
Deepika Lal ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copy Number Variation ◽  
Copy Number ◽  
Age At Onset ◽  
Subset Analysis ◽  
Number Variation

scholarly journals Copy Number Variation Identification on 3,800 Alzheimer’s Disease Whole Genome Sequencing Data from the Alzheimer’s Disease Sequencing Project

2021 ◽  
Vol 12 ◽  
Author(s):  
Wan-Ping Lee ◽  
Albert A. Tucci ◽  
Mitchell Conery ◽  
Yuk Yee Leung ◽  
Amanda B. Kuzma ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copy Number Variation ◽  
Copy Number ◽  
Whole Genome Sequence ◽  
Whole Genome Sequencing Data ◽  
Whole Genome ◽  
Sequencing Data ◽  
Sequencing Project ◽  
Number Variation

Alzheimer’s Disease (AD) is a progressive neurologic disease and the most common form of dementia. While the causes of AD are not completely understood, genetics plays a key role in the etiology of AD, and thus finding genetic factors holds the potential to uncover novel AD mechanisms. For this study, we focus on copy number variation (CNV) detection and burden analysis. Leveraging whole-genome sequence (WGS) data released by Alzheimer’s Disease Sequencing Project (ADSP), we developed a scalable bioinformatics pipeline to identify CNVs. This pipeline was applied to 1,737 AD cases and 2,063 cognitively normal controls. As a result, we observed 237,306 and 42,767 deletions and duplications, respectively, with an average of 2,255 deletions and 1,820 duplications per subject. The burden tests show that Non-Hispanic-White cases on average have 16 more duplications than controls do (p-value 2e-6), and Hispanic cases have larger deletions than controls do (p-value 6.8e-5).

scholarly journals Analysis of Copy Number Variation in Alzheimer’s Disease in a Cohort of Clinically Characterized and Neuropathologically Verified Individuals

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e50640 ◽  
Author(s):  
Shanker Swaminathan ◽  
Matthew J. Huentelman ◽  
Jason J. Corneveaux ◽  
Amanda J. Myers ◽  
Kelley M. Faber ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copy Number Variation ◽  
Copy Number ◽  
Number Variation
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